Skip Navigation
ChemIDplus LiteBrowseAdvanced

Substance Name: Flutoprazepam [INN:JAN]
RN: 25967-29-7
UNII: 2GHY1101MM
InChIKey: OFVXPDXXVSGEPX-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C19-H16-Cl-F-N2-O

Molecular Weight

  • 342.7994
 
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Flutoprazepam
  • Flutoprazepam [INN:JAN]

Synonyms

  • 2H-1,4-Benzodiazepin-2-one, 7-chloro-1-(cyclopropylmethyl)-5-(2-fluorophenyl)-1,3-dihydro-
  • 5-24-04-00321 (Beilstein Handbook Reference)
  • 7-Chloro-1-cyclopropylmethyl-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one
  • BRN 0898682
  • Flutoprazepam
  • Flutoprazepamum
  • Flutoprazepamum [INN-Latin]
  • ID-1937
  • KB-509
  • Restar
  • Restas
  • UNII-2GHY1101MM

Systematic Names

  • 2H-1,4-Benzodiazepin-2-one, 7-chloro-1-(cyclopropylmethyl)-5-(o-fluorophenyl)-1,3-dihydro-
  • 7-Chloro-1-(cyclopropylmethyl)-5-(o-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one

Registry Numbers

CAS Registry Number

  • 25967-29-7

FDA UNII

  • 2GHY1101MM

System Generated Number

  • 0025967297

Structure Descriptors

InChI

1S/C19H16ClFN2O/c20-13-7-8-17-15(9-13)19(14-3-1-2-4-16(14)21)22-10-18(24)23(17)11-12-5-6-12/h1-4,7-9,12H,5-6,10-11H2

InChIKey

OFVXPDXXVSGEPX-UHFFFAOYSA-N

Smiles

Fc1ccccc1C2=NCC(=O)N(CC3CC3)c4ccc(Cl)cc24

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 10gm/kg (10000mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

GASTROINTESTINAL: NAUSEA OR VOMITING
Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 1005, 1980.
monkey LD50 oral > 4gm/kg (4000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 1005, 1980.
monkey LD50 oral > 4gm/kg (4000mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

GASTROINTESTINAL: NAUSEA OR VOMITING
Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 1005, 1980.
mouse LD50 intraperitoneal 2110mg/kg (2110mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 1055, 1980.
mouse LD50 intraperitoneal 2110mg/kg (2110mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 1055, 1980.
mouse LD50 oral 2430mg/kg (2430mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 1055, 1980.
mouse LD50 oral 2430mg/kg (2430mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 1055, 1980.
mouse LD50 subcutaneous > 5gm/kg (5000mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: MUSCLE WEAKNESS
Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 1005, 1980.
rabbit LD50 oral 1gm/kg (1000mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: ATAXIA
Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 1055, 1980.
rat LD50 intraperitoneal 2230mg/kg (2230mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 1055, 1980.
rat LD50 oral 10060mg/kg (10060mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 1055, 1980.
rat LD50 oral 10060mg/kg (10060mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 1055, 1980.
rat LD50 subcutaneous > 5gm/kg (5000mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: ATAXIA
Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 1005, 1980.