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Substance Name: Ergotoxine
RN: 8006-25-5
UNII: 2J09Y26C6I
InChIKey: XLMJRFCCCWFQRE-SJRQCXNHSA-N

Note

  • A mixture of three different ergotaman-3',6',18-triones; toxic ergot alkaloid mixture of equal parts of erocornine, ergocristine & ergocryptine; has alpha adrenergic blocking action, stimulates smooth muscle & antagonizes serotonin; used as oxytocic & in peripheral vascular disorders.

Molecular Weight

  • 519.5987
 

Classification Codes

  • Human Data
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Ergotoxine

Synonyms

  • Ecboline
  • Ergotoxin
  • Ergotoxine
  • UNII-2J09Y26C6I

Systematic Name

  • Ergotoxine

Registry Numbers

CAS Registry Number

  • 8006-25-5

FDA UNII

  • 2J09Y26C6I

System Generated Number

  • 0008006255

Structure Descriptors

InChI

1S/C28H33N5O5/c1-15(2)27(26(36)33-14-23(34)32-9-5-8-22(32)28(33,37)38-27)30-25(35)17-10-19-18-6-4-7-20-24(18)16(12-29-20)11-21(19)31(3)13-17/h4,6-7,10,12,15,17,21-22,29,37H,5,8-9,11,13-14H2,1-3H3,(H,30,35)/t17-,21-,22+,27-,28+/m1/s1

InChIKey

XLMJRFCCCWFQRE-SJRQCXNHSA-N

Smiles

CC(C)[C@@]1(C(=O)N2CC(=O)N3CCC[C@H]3[C@@]2(O1)O)NC(=O)[C@H]4CN([C@@H]5Cc6c[nH]c7c6c(ccc7)C5=C4)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo intravenous 3570ng/kg (0.00357mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Handbuch der Experimentellen Pharmakologie. Vol. 6, Pg. 107, 1938.
mouse LD50 intravenous 33mg/kg (33mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 285, 1948.
mouse LDLo subcutaneous 107mg/kg (107mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 176, Pg. 171, 1934.
rabbit LDLo intravenous 1500ug/kg (1.5mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Handbuch der Experimentellen Pharmakologie. Vol. 6, Pg. 104, 1938.