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Substance Name: Guadecitabine [USAN:INN]
RN: 929901-49-5
UNII: 2KT4YN1DP7
InChIKey: GUWXKKAWLCENJA-WGWHJZDNSA-N

Notes

  • A 5-aza-2'-deoxycytidine-containing demethylating dinucleotide used in the treatment of acute myeloid leukemia.
  • A 5-aza-2'-deoxycytidine-containing demethylating dinucleotide.

Molecular Weight

  • 557.4146
 

Classification Codes

  • Antineoplastic
  • Antineoplastic Agents
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Names and Synonyms

Name of Substance

  • Guadecitabine [USAN:INN]
  • SGI-110 free acid

Synonyms

  • Guadecitabine
  • Guanosine, 2'-deoxy-5-azacytidylyl-(3'-5')-2'-deoxy-
  • SGI 110
  • UNII-2KT4YN1DP7

Registry Numbers

CAS Registry Number

  • 929901-49-5

FDA UNII

  • 2KT4YN1DP7

System Generated Number

  • 0929901495

Structure Descriptors

InChI

1S/C18H24N9O10P/c19-16-22-6-27(18(31)25-16)12-2-8(9(3-28)35-12)37-38(32,33)34-4-10-7(29)1-11(36-10)26-5-21-13-14(26)23-17(20)24-15(13)30/h5-12,28-29H,1-4H2,(H,32,33)(H2,19,25,31)(H3,20,23,24,30)/t7-,8-,9+,10+,11+,12+/m0/s1

InChIKey

GUWXKKAWLCENJA-WGWHJZDNSA-N

Smiles

c1nc2c(n1[C@H]3C[C@@H]([C@H](O3)COP(=O)(O)O[C@H]4C[C@@H](O[C@@H]4CO)n5cnc(nc5=O)N)O)[nH]c(nc2=O)N