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Substance Name: Pranoprofen [INN:JAN]
RN: 52549-17-4
UNII: 2R7O1ET613
InChIKey: TVQZAMVBTVNYLA-UHFFFAOYSA-N

Molecular Formula

  • C15-H13-N-O3

Molecular Weight

  • 255.272
 

Classification Codes

  • Analgesics
  • Analgesics, Non-Narcotic
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antirheumatic Agents
  • Drug / Therapeutic Agent
  • Gout Suppressants
  • Peripheral Nervous System Agents
  • Reproductive Effect
  • Sensory System Agents
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Names and Synonyms

Name of Substance

  • Pranoprofen
  • Pranoprofen [INN:JAN]
  • Pyranoprofen

Synonyms

  • 2-(5H-(1)Benzopyrano(2,3-b)pyridin-7-yl)propionic acid
  • 2-(5H-(1)Benzopyrano(2,3-b)pyridin-7yl)propionic acid
  • alpha-Methyl-5H-(1)-benzopyrano(2,3-b)pyridine-7-acetic acid
  • alpha-Methyl-5H-(1)benzopyrano(2,3-b)pyridine-7-acetic acid
  • BRN 0889798
  • Niflan
  • Pranoprofen
  • Pranoprofene
  • Pranoprofene [INN-French]
  • Pranoprofeno
  • Pranoprofeno [INN-Spanish]
  • Pranoprofenum
  • Pranoprofenum [INN-Latin]
  • UNII-2R7O1ET613
  • Y-8004

Systematic Names

  • 5H-(1)Benzopyrano(2,3,-b)pyridine-7-acetic acid, alpha-methyl-
  • alpha-Methyl-5H-(1)benzopyrano(2,3-b)pyridine-7-acetic acid

Registry Numbers

CAS Registry Number

  • 52549-17-4

FDA UNII

  • 2R7O1ET613

System Generated Number

  • 0052549174

Structure Descriptors

InChI

1S/C15H13NO3/c1-9(15(17)18)10-4-5-13-12(7-10)8-11-3-2-6-16-14(11)19-13/h2-7,9H,8H2,1H3,(H,17,18)

InChIKey

TVQZAMVBTVNYLA-UHFFFAOYSA-N

Smiles

O1c2c(cccn2)Cc2c1ccc([C@@H](C(=O)O)C)c2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 354mg/kg (354mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 211, 1976.
mouse LD50 oral 447mg/kg (447mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 211, 1976.
mouse LD50 subcutaneous 503mg/kg (503mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 1204, 1981.
rat LD50 intraperitoneal 51200ug/kg (51.2mg/kg)   Drugs in Japan Vol. 6, Pg. APP-18, 1982.
rat LD50 oral 59500ug/kg (59.5mg/kg)   Drugs in Japan Vol. 6, Pg. APP-18, 1982.
rat LD50 subcutaneous 51500ug/kg (51.5mg/kg)   Drugs in Japan Vol. 6, Pg. APP-18, 1982.