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Substance Name: Hydroxyzine [INN:BAN]
RN: 68-88-2
UNII: 30S50YM8OG
InChIKey: ZQDWXGKKHFNSQK-UHFFFAOYSA-N
Note
- A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative.
Molecular Formula
- C21-H27-Cl-N2-O2
Molecular Weight
- 374.9093
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Antipruritics
- Dermatologic Agents
- Drug / Therapeutic Agent
- Histamine Agents
- Histamine Antagonists
- Histamine H1 Antagonists
- Neurotransmitter Agents
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Hydroxyzine
- Hydroxyzine [INN:BAN]
MeSH Heading
- Hydroxyzine
Synonyms
- 1-(p-Chloro-alpha-phenylbenzyl)-4-(2-(2-hydroxyethoxy)ethyl)piperazine
- 1-(p-Chloro-alpha-phenylbenzyl)-4-(2-hydroxyethoxyethyl)piperazine
- 1-(p-Chlorobenzhydryl)-4-(2-(2-hydroxyethoxy)ethyl)diethylenediamine
- 1-(p-Chlorobenzhydryl)-4-(2-(2-hydroxyethoxy)ethyl)piperazine
- 1-(p-Chlorodiphenylmethyl)-4-(2-(2-hydroxyethoxy)ethyl)piperazine
- 2-(2-(4-(p-Chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)ethanol
- 5-23-01-00462 (Beilstein Handbook Reference)
- Atara
- Atarax base
- Ataraxoid
- Atarazoid
- Atarox
- Atazina
- Aterax
- BRN 0321392
- Deinait
- EINECS 200-693-1
- Equipoise
- Ethanol, 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-
- Ethanol, 2-(2-(4-(p-chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)-
- Fenarol
- Hidroxizina
- Hidroxizina [INN-Spanish]
- HSDB 3098
- Hychotine
- Hydroksyzyny
- Hydroksyzyny [Polish]
- Hydroxine
- Hydroxizine
- Hydroxizinum
- Hydroxycine
- Hydroxyzin
- Hydroxyzine
- Hydroxyzinum
- Hydroxyzinum [INN-Latin]
- Idrossizina
- Idrossizina [DCIT]
- N-(4-Chlorobenzhydryl)-N'-(hydroxyethoxyethyl)piperazine
- N-(4-Chlorobenzhydryl)-N'-(hydroxyethyloxyethyl)piperazine
- Neo-calma
- Neurozina
- Nevrolaks
- NP 212
- NSC 169188
- Pamazone
- Parenteral
- Paxistil
- Placidol
- Plaxidol
- Tran-Q
- Tranquizine
- Traquizine
- U.C.B 4492
- U.CB 4492
- UCB 4492
- UCB 492
- UNII-30S50YM8OG
- Vesparaz-wirkstoff
Systematic Names
- Ethanol, 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-
- Ethanol, 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)- (9CI)
- Ethanol, 2-(2-(4-(p-chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)-
- Hydroxyzine
Registry Numbers
CAS Registry Number
- 68-88-2
FDA UNII
- 30S50YM8OG
Related Registry Numbers
- 10246-75-0 (pamoate)
- 2192-20-3 (di-hydrochloride)
System Generated Number
- 0000068882
Structure Descriptors
InChI
InChI=1S/C21H27ClN2O2/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25/h1-9,21,25H,10-17H2InChIKey
ZQDWXGKKHFNSQK-UHFFFAOYSA-NSmiles
OCCOCCN1CCN(CC1)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 81300ug/kg (81.3mg/kg) | Dissertationes Pharmaceuticae et Pharmacologicae. Vol. 23, Pg. 281, 1971. | |
mouse | LD50 | intravenous | 137mg/kg (137mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 237, 1972. | |
mouse | LD50 | oral | 400mg/kg (400mg/kg) | Chimica Therapeutica. Vol. 3, Pg. 210, 1968. | |
rat | LD50 | intraperitoneal | 160mg/kg (160mg/kg) | Chimica Therapeutica. Vol. 3, Pg. 210, 1968. | |
rat | LD50 | intravenous | 45mg/kg (45mg/kg) | Acta Neurologia et Psychiatrica Belgica. Vol. 61, Pg. 669, 1961. | |
rat | LD50 | oral | 840mg/kg (840mg/kg) | Chimica Therapeutica. Vol. 3, Pg. 210, 1968. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
log P (octanol-water) | 2.360 | (none) | EST | |
Atmospheric OH Rate Constant | 2.48E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.