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Substance Name: Beraprost [USAN:INN]
RN: 88430-50-6
UNII: 35E3NJJ4O6
InChIKey: CTPOHARTNNSRSR-APJZLKAGSA-N

Note

  • Stable prostacyclin analog.

Molecular Formula

  • C24-H30-O5

Molecular Weight

  • 398.496
 

Classification Codes

  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Hematologic Agents
  • Platelet Aggregation Inhibitor
  • Platelet Aggregation Inhibitors
  • Vasodilator Agents
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Names and Synonyms

Name of Substance

  • Beraprost
  • Beraprost [USAN:INN]

Synonyms

  • (+-)-(1R,2R,3aS,8bS)-2,3,3a,8b-Tetrahydro-2-hydroxy-1-((E)-(3S,4RS)-3-hydroxy-4-methyl-1-octen-6-ynyl)-1H-cyclopenta(b)benzofuran-5-butyric acid
  • 1H-Cyclopenta(b)benzofuran-5-butanoic acid, 2,3,3a,8b-tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-ynyl)-
  • 2-Hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-ynyl)-2,3,3a,8b-tetrahydro-1H-cyclopenta(b)benzofuran-5-butanoic acid
  • Beraprost
  • Beraprostum
  • Beraprostum [INN-Latin]
  • MDL 201229
  • MDL-201229
  • ML 1229
  • ML-1229
  • UNII-35E3NJJ4O6

Systematic Name

  • 1H-Cyclopenta(b)benzofuran-5-butanoic acid, 2,3,3a,8b-tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-ynyl)-

Registry Numbers

CAS Registry Number

  • 88430-50-6

FDA UNII

  • 35E3NJJ4O6

Related Registry Number

  • 88475-69-8 (hydrochloride salt)

System Generated Number

  • 0088430506

Structure Descriptors

InChI

InChI=1S/C24H30O5/c1-3-4-7-15(2)19(25)13-12-17-20(26)14-21-23(17)18-10-5-8-16(24(18)29-21)9-6-11-22(27)28/h5,8,10,12-13,15,17,19-21,23,25-26H,6-7,9,11,14H2,1-2H3,(H,27,28)/b13-12+/t15?,17-,19+,20+,21-,23-/m0/s1

InChIKey

CTPOHARTNNSRSR-APJZLKAGSA-N

Smiles

CC#CCC(C)[C@H](O)\C=C\[C@H]1[C@H](O)C[C@@H]2Oc3c(CCCC(=O)O)cccc3[C@H]12

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LD50 intravenous 13mg/kg (13mg/kg)   Japanese Kokai Tokyo Koho Patents. Vol. #92-312531,
rat LD50 oral 12mg/kg (12mg/kg)   Japanese Kokai Tokyo Koho Patents. Vol. #92-312531,
rat LD50 subcutaneous 7mg/kg (7mg/kg)   Japanese Kokai Tokyo Koho Patents. Vol. #92-312531,