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Substance Name: Epafipase [USAN:INN]
RN: 208576-22-1
UNII: 369989188P


  • A lipoprotein-associated PHOSPHOLIPASE A2 which modulates the action of PLATELET ACTIVATING FACTOR by hydrolyzing the SN-2 ester bond to yield the biologically inactive lyso-platelet-activating factor. It has specificity for phospholipid substrates with short-chain residues at the SN-2 position, but inactive against long-chain phospholipids. Deficiency in this enzyme is associated with many diseases including ASTHMA, and HYPERCHOLESTEROLEMIA.

Classification Codes

  • Antiallergenic
  • Antiallergic
  • Antiasthmatic
  • Antiasthmatic (PAF Antagonist (PAF Acetylhydrolase))
  • PAF Antagonist
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Names and Synonyms

Name of Substance

  • Epafipase [USAN:INN]

MeSH Heading

  • 1-Alkyl-2-acetylglycerophosphocholine Esterase


  • 6-400-Deacetylase, 1-alkyl-2-acetyllecithin (human)
  • 6-400-Deacetylase, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (human). Molecular weight is approximately 44,799 daltons
  • Epafipase
  • PAF acetylhydrolase
  • Pafase
  • rPAF-AH
  • UNII-369989188P

Systematic Names

  • 2-Acetyl-1-alkyl-sn-glycero-3-phosphocholine deacetylase-(6-400)-peptide (human)
  • Deacetylase, 1-alkyl-2-acetyllecithin (human)

Registry Numbers

CAS Registry Number

  • 208576-22-1


  • 369989188P

System Generated Number

  • 0208576221