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Substance Name: Umbralisib [USAN]
RN: 1532533-67-7
UNII: 38073MQB2A
InChIKey: IUVCFHHAEHNCFT-INIZCTEOSA-N

Note

  • An oral PI3K-gamma-specific inhibitor for treatment of Hodgkin disease.

Classification Code

  • Treatment of Cancer and B-Cell Related Disorders

Molecular Formula

  • C31-H24-F3-N5-O3

Molecular Weight

  • 571.5566
 
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Names and Synonyms

Name of Substance

  • TGR-1202
  • Umbralisib [USAN]

Synonyms

  • 2-((1S)-1-(4-Amino-3-(3-fluoro-4-(1-methylethoxy)phenyl)-1H-pyrazolo(3,4-d)pyrimidin-1-yl)ethyl)-6-fluoro-3-(3-fluorophenyl)-4H-1-benzopyran-4-one
  • RP 5264
  • RP-5264
  • TGR 1202
  • TGR 1202 [WHO-DD]
  • TGR-1202
  • TGR-1202 base
  • TGR-1202 free base
  • Umbralisib
  • UNII-38073MQB2A

Registry Numbers

CAS Registry Number

  • 1532533-67-7

FDA UNII

  • 38073MQB2A

System Generated Number

  • 1532533677

Structure Descriptors

InChI

InChI=1S/C31H24F3N5O3/c1-15(2)41-24-9-7-18(12-22(24)34)27-26-30(35)36-14-37-31(26)39(38-27)16(3)29-25(17-5-4-6-19(32)11-17)28(40)21-13-20(33)8-10-23(21)42-29/h4-16H,1-3H3,(H2,35,36,37)/t16-/m0/s1

InChIKey

IUVCFHHAEHNCFT-INIZCTEOSA-N

Smiles

CC(C)Oc1ccc(cc1F)c2nn([C@@H](C)C3=C(C(=O)c4cc(F)ccc4O3)c5cccc(F)c5)c6ncnc(N)c26