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Substance Name: Pegfilgrastim [USAN:INN:BAN]
RN: 208265-92-3
UNII: 3A58010674

Notes

  • Pegylated (r-G-CSF) conjugated to polyethylene glycol for treatment of neutropenic patients with non-myeloid malignancies who are at high risk for infection.
  • Pegylated (r-G-CSF) conjugated to polyethylene glycol for treatment of neutropenic patients with non-myeloid malignancies who are at high risk for infection.

    NCI: pegfilgrastim. A long-acting pegylated form of a recombinant therapeutic agent which is chemically identical to or similar to an endogenous human granulocyte colony-stimulating factor (G-CSF). Produced endogenously by monocytes, fibroblasts, and endothelial cells, G-CSF binds to and activates specific cell surface receptors, stimulating neutrophil progenitor proliferation and differentiation and selected neutrophil functions. Conjugation of the cytokine with a branched polyethylene glycol molecule (pegylation) significantly increases its therapeutic half-life. (NCI Thesaurus)

Molecular Formula

  • Unspecified

Molecular Weight

  • 18914.9439
 

Classification Codes

  • Antineoplastic Agents
  • Pegylated Protein
  • Treatment of Neutropenia Associated with E.G. Myelosuppressive Chemotherapy or Bone Marrow Transplantation

Names and Synonyms

Name of Substance

  • Pegfilgrastim
  • Pegfilgrastim [USAN:INN:BAN]

Synonyms

  • HSDB 8157
  • N-(3-Hydroxypropyl)methionylcolony-stimulating factor (human), 1-ether with alpha-methyl-omega-hydroxypoly(oxyethylene)
  • Neulasta
  • Neupopeg
  • PEG-filgrastim
  • Pegfilgrastim
  • UNII-3A58010674

Systematic Name

  • Colony-stimulating factor (human), 3-hydroxypropyl-N-methionyl-, 1-ether with alpha-methyl-omega-hydroxypoly(oxy-1,2-ethanediyl

Registry Numbers

CAS Registry Number

  • 208265-92-3

FDA UNII

  • 3A58010674

System Generated Number

  • 0208265923

Structure Descriptors

Smiles

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