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Substance Name: Pegfilgrastim [USAN:INN:BAN]
RN: 208265-92-3
UNII: 3A58010674
Notes
- Pegylated (r-G-CSF) conjugated to polyethylene glycol for treatment of neutropenic patients with non-myeloid malignancies who are at high risk for infection.
- Pegylated (r-G-CSF) conjugated to polyethylene glycol for treatment of neutropenic patients with non-myeloid malignancies who are at high risk for infection.
NCI: pegfilgrastim. A long-acting pegylated form of a recombinant therapeutic agent which is chemically identical to or similar to an endogenous human granulocyte colony-stimulating factor (G-CSF). Produced endogenously by monocytes, fibroblasts, and endothelial cells, G-CSF binds to and activates specific cell surface receptors, stimulating neutrophil progenitor proliferation and differentiation and selected neutrophil functions. Conjugation of the cytokine with a branched polyethylene glycol molecule (pegylation) significantly increases its therapeutic half-life. (NCI Thesaurus)
Molecular Formula
- Unspecified
Molecular Weight
- 18914.9439
Classification Codes
- Antineoplastic Agents
- Pegylated Protein
- Treatment of Neutropenia Associated with E.G. Myelosuppressive Chemotherapy or Bone Marrow Transplantation
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Links to Resources
NLM Resources (File Locators)
Other Resources (Internet Locators)
Names and Synonyms
Name of Substance
- Pegfilgrastim
- Pegfilgrastim [USAN:INN:BAN]
Synonyms
- HSDB 8157
- N-(3-Hydroxypropyl)methionylcolony-stimulating factor (human), 1-ether with alpha-methyl-omega-hydroxypoly(oxyethylene)
- Neulasta
- Neupopeg
- PEG-filgrastim
- Pegfilgrastim
- UNII-3A58010674
Systematic Name
- Colony-stimulating factor (human), 3-hydroxypropyl-N-methionyl-, 1-ether with alpha-methyl-omega-hydroxypoly(oxy-1,2-ethanediyl
Registry Numbers
CAS Registry Number
- 208265-92-3
FDA UNII
- 3A58010674
System Generated Number
- 0208265923