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Substance Name: Pegaptanib sodium [USAN]
RN: 222716-86-1
UNII: 3HP012Q0FH

Note

  • A 28-base ribonucleic acid aptamer covalently linked to two branched 20-kD polyethylene glycol moieties to block the activity of extracellular VEGF, specifically the 165-amino-acid isoform (VEGF165); for treatment of neovascular age-related macular degeneration.

Molecular Formulas

  • C294-H342-F13-N107-Na28-O188-P28-(C2-H4-O)n-
  • Unspecified
 

Classification Code

  • Treatment of Age-Related Macular Degeneration Disease (Anti-VEGF Apatamer)

Names and Synonyms

Name of Substance

  • Pegaptanib sodium [USAN]

Synonyms

  • 5'-Ester of (2'-deoxy-2'-fluoro)C-Gm-Gm-A-A-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-Am-Gm-(2'-deoxy-2'-fluoro)U-Gm-Am-Am-(2'-deoxy-2'-fluoro)U-Gm-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)C-Am-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)C-Gm-(3'-3')-dT with alpha,alpha'-(((1S)-1-((5-(phosphonooxy)pentyl)carbamoyl)pentane-1,5-diyl)bis(iminocarbonyl))bis(omega-methoxypoly(oxyethane-1,2-diyl)) octacosasodium salt. Molecular weight is approximately 50,000 daltons
  • EYE 001
  • EYE001
  • Macugen
  • NX 1838
  • NX1838
  • Pegaptanib
  • Pegaptanib octasodium
  • Pegaptanib sodium
  • UNII-3HP012Q0FH

Systematic Name

  • RNA, ((2'-deoxy-2'-fluoro)C-Gm-Gm-A-A-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-Am-Gm-(2'-deoxy-2'-fluoro)U-Gm-Am-Am-(2'-deoxy-2'-fluoro)U-Gm-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)C-Am-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)C-Gm-(3'-3')-dT), 5'-ester withalpha,alpha'-(4,12-dioxo-6-(((5-(phosphonooxy)pentyl)amino)carbonyl)-3,13-dioxa-5,11-diaza-1,15-pentadecanediyl)bis(omega-methoxypoly(oxy-1,2-ethanediyl)), sodium salt

Registry Numbers

CAS Registry Number

  • 222716-86-1

FDA UNII

  • 3HP012Q0FH

Other Registry Number

  • 250689-71-5

System Generated Number

  • 0222716861