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Substance Name: Natalizumab [USAN:INN:BAN]
RN: 189261-10-7


  • A humanized monoclonal immunoglobulin G4 antibody to human INTEGRIN ALPHA4 that binds to the alpha4 subunit of INTEGRIN ALPHA4BETA1 and integrin alpha4beta7. It is used as an IMMUNOLOGIC FACTOR in the treatment of RELAPSING-REMITTING MULTIPLE SCLEROSIS and CROHN'S DISEASE.

Molecular Formula

  • Unspecified

Classification Code

  • Immunologic Factors

Names and Synonyms

Name of Substance

  • Natalizumab
  • Natalizumab [USAN:INN:BAN]

MeSH Heading

  • Natalizumab


  • Antegren
  • HSDB 8174
  • Immunoglobulin G 4 (human-mouse monoclonal AN100226 4-chain anti-human integrin 4), disulfide with human-mouse monoclonal AN100226 light chain, dimer
  • Natalizumab
  • Tysabri
  • UNII-3JB47N2Q2P

Systematic Name

  • Immunoglobulin G4, anti-(human integrin alpha4) (human-mouse monoclonal AN100226 gamma4-chain), disulfide with human-mouse monoclonal AN100226 light chain, dimer

Registry Numbers

CAS Registry Number

  • 189261-10-7


  • 3JB47N2Q2P

System Generated Number

  • 0189261107