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Substance Name: Clindamycin [USAN:INN:BAN]
RN: 18323-44-9
UNII: 3U02EL437C
InChIKey: KDLRVYVGXIQJDK-AWPVFWJPSA-N
Note
- An antibacterial agent that is a semisynthetic analog of LINCOMYCIN.
Molecular Formula
- C18-H33-Cl-N2-O5-S
Molecular Weight
- 424.9867
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Anti-Bacterial Agents
- Anti-Infective Agents
- Antibacterial
- Drug / Therapeutic Agent
- Enzyme Inhibitors
- Protein Synthesis Inhibitors
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Names and Synonyms
Name of Substance
- Clindamycin
- Clindamycin [USAN:INN:BAN]
MeSH Heading
- Clindamycin
Synonyms
- 7(S)-Chloro-7-deoxylincomycin
- 7-CDL
- 7-Chloro-7-deoxylincomycin
- 7-Chlorolincomycin
- 7-Deoxy-7(S)-chlorolincomycin
- Antirobe
- Chlolincocin
- Cleocin
- ClindaDerm
- Clindamicina
- Clindamicina [INN-Spanish]
- Clindamycin
- Clindamycine
- Clindamycine [French]
- Clindamycine [INN-French]
- Clindamycinum
- Clindamycinum [INN-Latin]
- Clinimycin
- Dalacin C
- Dalacine
- EINECS 242-209-1
- HSDB 3037
- Klimicin
- Klindan 300
- Methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-alpha-D-galacto-octopyranoside
- Sobelin
- U 21251
- U-21,251
- UNII-3U02EL437C
Systematic Names
- Clindamycin
- L-threo-alpha-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-((((2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl)carbonyl)amino)-1-thio-
- L-threo-alpha-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-(((1-methyl-4-propyl-2-pyrrolidinyl)carbonyl)amino)-1-thio-, (2S-trans)-
- L-threo-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-, trans-alpha-
Registry Numbers
CAS Registry Number
- 18323-44-9
FDA UNII
- 3U02EL437C
Other Registry Numbers
- 13441-63-9
- 16669-21-9
- 24620-78-8
- 24696-19-3
Related Registry Numbers
- 21462-39-5 (mono-hydrochloride)
- 58207-19-5 (mono-HCl, mono-hydrate)
System Generated Number
- 0018323449
Structure Descriptors
InChI
1S/C18H33ClN2O5S/c1-5-6-10-7-11(21(3)8-10)17(25)20-12(9(2)19)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,22-24H,5-8H2,1-4H3,(H,20,25)/t9-,10+,11-,12+,13-,14+,15+,16+,18+/m0/s1InChIKey
KDLRVYVGXIQJDK-AWPVFWJPSA-NSmiles
CCC[C@@H]1C[C@H](N(C)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| hamster | LDLo | oral | 1mg/kg (1mg/kg) | GASTROINTESTINAL: OTHER CHANGES | Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 794, 1984. |
| rabbit | LDLo | oral | 1mg/kg (1mg/kg) | Recueil de Medecine Veterinaire. Vol. 156, Pg. 915, 1980. | |
| rat | LD50 | subcutaneous | 2618mg/kg (2618mg/kg) | Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| log P (octanol-water) | 2.16 | (none) | EXP | |
| Water Solubility | 30.6 | mg/L | 25 | EST |
| Vapor Pressure | 5.28E-17 | mm Hg | 25 | EST |
| Henry's Law Constant | 2.89E-22 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 2.63E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.