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Substance Name: Macrogol [INN]
RN: 25322-68-3

Notes

  • A tasteless laxative composed of PEG3350; Miralax is tradename.
  • Polymers of ETHYLENE OXIDE and water and their ethers. They vary in consistency from liquid to solid, depending on the molecular weight, indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are lauromagrogols, nonoxynols, octoxynols and poloxamers.
  • Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS.

Molecular Formulas

  • (C2-H4-O)mult-
  • (C2-H4-O)mult-H2-O

Molecular Weight

  • 44.0526
 

Classification Codes

  • Drug / Therapeutic Agent
  • Drug Carriers
  • Excipients
  • Gastrointestinal Agents
  • Laxatives
  • Mutation Data
  • Pharmaceutic Aid (Ointment Base)
  • Pharmaceutic Aid (Solvent)
  • Pharmaceutic Aid (Suppository Base)
  • Pharmaceutic Aid (Suspending and/or Viscosity Agent)
  • Pharmaceutic Aid (Tablet and/or Capsule Lubricant)
  • Pharmaceutic Aid (Tablet Binder)
  • Pharmaceutic Aid (Tablet Excipient)
  • Pharmaceutic Aids
  • Pharmaceutical Vehicles
  • Skin / Eye Irritant
  • Solvents
  • Surface-Active Agents
  • TSCA Flag XU (Exempt from Reporting under Chemical Data Reporting Rule)
  • Tumor Data

Names and Synonyms

Results Name

  • Macrogol [INN]

Name of Substance

  • Ethanol, 2,2'-(oxybis(2,1-ethanediyloxy)bis-
  • Macrogol [BAN:JAN]
  • Macrogol [INN]
  • Polyethylene glycol
  • Polyethylene glycol 1000
  • Polyethylene glycol 1450
  • Polyethylene glycol 1500
  • Polyethylene glycol 1540
  • Polyethylene glycol 200
  • Polyethylene glycol 2000
  • Polyethylene glycol 300
  • Polyethylene glycol 3350
  • Polyethylene glycol 3500
  • Polyethylene glycol 400
  • Polyethylene glycol 4000
  • Polyethylene glycol 4500
  • Polyethylene glycol 7000
  • Polyethylene glycol 800
  • Polyethylene glycol 8000
  • Polyethylene glycol 900
  • Polyethylene glycol [NF]
  • Polyox wsr-N 60

MeSH Heading

  • Polyethylene Glycols

Synonyms

  • 1,2-Ethanediol homopolymer
  • Alcox E 30
  • Alkox E 100
  • Alkox E 130
  • Alkox E 160
  • Alkox E 240
  • Alkox E 45
  • Alkox E 60
  • Alkox E 75
  • Alkox R 1000
  • Alkox R 15
  • Alkox R 150
  • Alkox R 400
  • Alkox SR
  • alpha-Hydro-omega-hydroxypoly(oxy-1,2-ethanediyl)
  • alpha-Hydro-omega-hydroxypoly(oxyethylene)
  • Antarox E 4000
  • Aquacide III
  • Aquaffin
  • Atpeg 300
  • Atpeg 4000
  • Badimol
  • BDH 301
  • Bradsyn PEG
  • Breox 2000
  • Breox 20M
  • Breox 4000
  • Breox 550
  • Breox PEG 300
  • CAFO 154
  • Carbowax
  • Carbowax 100
  • Carbowax 1000
  • Carbowax 1350
  • Carbowax 14000
  • Carbowax 1500
  • Carbowax 1540
  • Carbowax 20
  • Carbowax 200
  • Carbowax 20000
  • Carbowax 25000
  • Carbowax 300
  • Carbowax 3350
  • Carbowax 400
  • Carbowax 4000
  • Carbowax 4500
  • Carbowax 4600
  • Carbowax 600
  • Carbowax 8000
  • Carbowax Sentry
  • CCRIS 979
  • Clearlax
  • DD 3002
  • Deactivator H
  • EC 500-038-2
  • EINECS 266-688-1
  • Emkapol 4200
  • Ethoxylated 1,2-ethanediol
  • Ethylene glycol homopolymer
  • Ethylene glycol polymer
  • Forlax
  • Gafanol E 200
  • Gavilax
  • Glycols, polyethylene
  • HM 500
  • HSDB 5159
  • Lanogene C
  • Lutrol
  • Lutrol E
  • Macrogol
  • Macrogol 300
  • Macrogol 3350
  • Macrogol 6000
  • Merpol OJ
  • Miralax
  • Modopeg
  • Nosilen
  • NSC 152324
  • Nycoline
  • Oxide Wax AN
  • Oxyethylene polymer
  • PEG
  • PEG 1000
  • PEG 1500
  • PEG 1540
  • PEG 200
  • PEG 300
  • PEG 3350
  • PEG 3500
  • PEG 400
  • PEG 4000
  • PEG 4500
  • PEG 6000
  • PEG 6000DS
  • PEG 800
  • PEG 8000
  • PEG 8o00
  • PEG 900
  • PEG-1000
  • PEG-1500
  • PEG-1540
  • PEG-200
  • PEG-300
  • PEG-3350
  • PEG-3500
  • PEG-400
  • PEG-4000
  • PEG-4500
  • PEG-800
  • PEG-8000
  • PEG-900
  • PEO-400
  • Plenvu
  • Pluracol E
  • Pluracol E 400, E 600, E 1450
  • Pluriol E 200
  • Poly(oxy-1,2-ethanediyl)
  • Poly(oxy-1,2-ethanediyl, alpha-hydro-omega-hydroxy-
  • Poly-G
  • Poly-G600
  • Polyethylene glycol
  • Polyethylene glycol 1000
  • Polyethylene glycol 1450
  • Polyethylene glycol 1500
  • Polyethylene glycol 1540
  • Polyethylene glycol 200
  • Polyethylene glycol 300
  • Polyethylene glycol 3350
  • Polyethylene glycol 3500
  • Polyethylene glycol 400
  • Polyethylene glycol 4000
  • Polyethylene glycol 4500
  • Polyethylene glycol 6000
  • Polyethylene glycol 7000
  • Polyethylene glycol 800
  • Polyethylene glycol 8000
  • Polyethylene glycol 900
  • Polyethylene oxide
  • Polyglycol E 300, E 400, E 1450, E 8000
  • Polyox WSR N-60K
  • Polyoxyethylene ether
  • Sentry polyox WSR
  • Sulfate-free electrolyte lavage solution
  • UNII-11628IH70O
  • UNII-1212Z7S33A
  • UNII-16P9295IIL
  • UNII-2126FD486L
  • UNII-2L7WA456VA
  • UNII-30IQX730WE
  • UNII-3H4G04L531
  • UNII-3IG9032SAH
  • UNII-3WJQ0SDW1A
  • UNII-439X29GCJZ
  • UNII-4QIB4U4CQR
  • UNII-4R4HFI6D95
  • UNII-5246R0812J
  • UNII-5655G9Y8AQ
  • UNII-5IRA46LB71
  • UNII-5K3991GVWI
  • UNII-5WKN5KL2O8
  • UNII-74D3A2BP47
  • UNII-761NX2Q08Y
  • UNII-762678AC5R
  • UNII-77HY82S0LG
  • UNII-7Z3ER739EB
  • UNII-8EIY1IHX76
  • UNII-9XH9HVO466
  • UNII-B697894SGQ
  • UNII-FVS1AZD90Y
  • UNII-G2M7P15E5P
  • UNII-G3MS6M810Y
  • UNII-H57W405143
  • UNII-HAF0412YIT
  • UNII-HZ58M6D839
  • UNII-NL4J9F21N9
  • UNII-OJ4Z5Z32L4
  • UNII-Q0JET65GEL
  • UNII-Q662QK8M3B
  • UNII-R0XY39567G
  • UNII-RU64142H6P
  • UNII-RVV61677RZ
  • UNII-SA1B764746
  • UNII-TU0XPZ7FZT
  • UNII-TVH7653921
  • UNII-U076Q6Q621
  • UNII-U95VVU3IDQ
  • UNII-UEP843BRCQ
  • UNII-UH6KR4953D
  • UNII-V146K8QJ07
  • UNII-V46Y6OJ5QB
  • UNII-VM53EE110J
  • UNII-X83H03O8BZ
  • UNII-Y4QO2MSY3X
  • UNII-ZBR3T82M2V

Systematic Names

  • Glycols, polyethylene
  • Poly(oxy-1,2-ethanediyl)
  • Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-hydroxy-
  • Poly(oxy-1,2-ethanediyl),alpha-hydro-omega-hydroxy- ethane-1,2-diol, ethoxylated
  • Polyethylene glycol
  • WSR-301

Superlist Names

  • Ethylene oxide polymer
  • Glycols, polyethylene
  • PEG
  • Polyethylene glycol

Mixture Name

  • Colyte

Registry Numbers

CAS Registry Number

  • 25322-68-3

FDA UNIIs

  • 11628IH70O
  • 1212Z7S33A
  • 16P9295IIL
  • 2126FD486L
  • 2L7WA456VA
  • 30IQX730WE
  • 3H4G04L531
  • 3IG9032SAH
  • 3WJQ0SDW1A
  • 439X29GCJZ
  • 4QIB4U4CQR
  • 4R4HFI6D95
  • 5246R0812J
  • 5655G9Y8AQ
  • 5IRA46LB71
  • 5K3991GVWI
  • 5WKN5KL2O8
  • 74D3A2BP47
  • 761NX2Q08Y
  • 762678AC5R
  • 77HY82S0LG
  • 7Z3ER739EB
  • 8EIY1IHX76
  • 9XH9HVO466
  • B697894SGQ
  • FVS1AZD90Y
  • G2M7P15E5P
  • G3MS6M810Y
  • H57W405143
  • HAF0412YIT
  • HZ58M6D839
  • NL4J9F21N9
  • OJ4Z5Z32L4
  • Q0JET65GEL
  • Q662QK8M3B
  • R0XY39567G
  • RU64142H6P
  • RVV61677RZ
  • SA1B764746
  • TU0XPZ7FZT
  • TVH7653921
  • U076Q6Q621
  • U95VVU3IDQ
  • UEP843BRCQ
  • UH6KR4953D
  • V146K8QJ07
  • V46Y6OJ5QB
  • VM53EE110J
  • X83H03O8BZ
  • Y4QO2MSY3X
  • ZBR3T82M2V

Other Registry Numbers

  • 1011711-38-8
  • 101677-86-5
  • 1033001-32-9
  • 1035554-64-3
  • 106186-24-7
  • 107502-63-6
  • 107529-96-4
  • 109550-27-8
  • 112384-37-9
  • 112895-21-3
  • 113041-64-8
  • 114323-93-2
  • 1152430-37-9
  • 116549-90-7
  • 1186292-40-9
  • 1186292-41-0
  • 119219-06-6
  • 1204298-97-4
  • 1221382-78-0
  • 1221382-83-7
  • 1221889-65-1
  • 1246265-64-4
  • 125223-68-9
  • 1256377-90-8
  • 1267533-36-7
  • 12676-74-3
  • 12770-93-3
  • 1287768-38-0
  • 1293291-01-6
  • 1319730-68-1
  • 1330618-78-4
  • 133573-31-6
  • 1338951-32-8
  • 134919-43-0
  • 1373256-89-3
  • 1377964-82-3
  • 1422717-42-7
  • 1429745-88-9
  • 1434253-80-1
  • 1435263-27-6
  • 1446681-77-1
  • 1474108-09-2
  • 150872-82-5
  • 154394-38-4
  • 156948-19-5
  • 1613520-06-1
  • 1620693-21-1
  • 1628723-15-8
  • 1636129-20-8
  • 169046-53-1
  • 1696472-65-7
  • 1710469-72-9
  • 174460-08-3
  • 174460-09-4
  • 1800416-42-5
  • 1809027-71-1
  • 1852508-98-5
  • 1873338-22-7
  • 188364-77-4
  • 188924-03-0
  • 189154-62-9
  • 191743-71-2
  • 1927875-70-4
  • 196696-84-1
  • 201163-43-1
  • 2015216-86-9
  • 206357-86-0
  • 2088235-52-1
  • 2092889-80-8
  • 2122851-44-7
  • 2170314-63-1
  • 221638-71-7
  • 225502-44-3
  • 2394768-82-0
  • 2409576-55-0
  • 2417963-12-1
  • 25104-58-9
  • 25609-81-8
  • 270910-26-4
  • 307928-07-0
  • 34802-42-1
  • 356055-70-4
  • 37361-15-2
  • 391229-98-4
  • 402483-26-5
  • 411207-22-2
  • 497171-83-2
  • 50809-04-6
  • 50809-59-1
  • 51312-32-4
  • 54510-95-1
  • 54847-64-2
  • 59763-40-5
  • 60894-12-4
  • 615575-04-7
  • 61840-14-0
  • 64441-68-5
  • 64640-28-4
  • 67411-64-7
  • 6790-09-6
  • 70926-57-7
  • 75285-02-8
  • 75285-03-9
  • 77986-38-0
  • 79964-26-4
  • 80341-53-3
  • 8038-37-7
  • 85399-22-0
  • 857367-46-5
  • 859315-72-3
  • 85945-29-5
  • 863328-36-3
  • 876655-84-4
  • 88077-80-9
  • 886469-28-9
  • 88747-22-2
  • 9002-90-8
  • 90597-70-9
  • 9081-95-2
  • 9085-02-3
  • 9085-03-4
  • 952682-62-1
  • 956217-69-9
  • 959127-49-2
  • 99264-61-6
  • 99333-89-8

System Generated Number

  • 0025322683

Molecular Formulas

Molecular Formulas

  • (C2-H4-O)mult-
  • (C2-H4-O)mult-H2-O

Molecular Formula Fragments

  • C2-H4-O
  • COMPONENT
  • H2-O

Structure Descriptors

Smiles


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 3gm/kg (3000mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 103, Pg. 293, 1951.
guinea pig LD50 oral 15700mg/kg (15700mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
guinea pig LD50 oral 17gm/kg (17000mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982.
guinea pig LD50 oral 19600mg/kg (19600mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
guinea pig LD50 oral 22500mg/kg (22500mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 39, Pg. 349, 1950.
guinea pig LD50 oral 28gm/kg (28000mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982.
guinea pig LD50 oral 28900mg/kg (28900mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
guinea pig LD50 oral 50gm/kg (50000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
guinea pig LD50 oral 50900mg/kg (50900mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
mouse LD50 intraperitoneal 473mg/kg (473mg/kg)   Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 21, Pg. 387, 1986.
mouse LD50 intraperitoneal 2gm/kg (2000mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Journal of Pharmacology and Experimental Therapeutics. Vol. 103, Pg. 293, 1951.
mouse LD50 intraperitoneal 7500mg/kg (7500mg/kg)   National Technical Information Service. Vol. AD628-313,
mouse LD50 intraperitoneal 8gm/kg (8000mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Journal of Pharmacology and Experimental Therapeutics. Vol. 103, Pg. 293, 1951.
mouse LD50 intravenous 7900ug/kg (7.9mg/kg)   Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 316, 1970.
mouse LD50 intravenous 8550mg/kg (8550mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976.
mouse LD50 intravenous 16gm/kg (16000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
mouse LD50 oral 28915mg/kg (28915mg/kg)   Proceedings of the European Society of Toxicology. Vol. 17, Pg. 351, 1976.
mouse LD50 oral 31gm/kg (31000mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982.
mouse LD50 oral 34gm/kg (34000mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982.
mouse LD50 oral 36gm/kg (36000mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982.
mouse LD50 subcutaneous 18gm/kg (18000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rabbit LD skin > 1gm/kg (1000mg/kg)   Union Carbide Data Sheet. Vol. 9/25/1969,
rabbit LD50 intravenous 8gm/kg (8000mg/kg) BLOOD: CHANGE IN CLOTTING FACTORS Kriobiologiya i Kriomeditsina. Cryobiology and Cryomedicine. Vol. 4, Pg. 71, 1978.
rabbit LD50 oral 14gm/kg (14000mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982.
rabbit LD50 oral 17300mg/kg (17300mg/kg)   International Journal of Toxicology. Vol. 18(Suppl,
rabbit LD50 oral 17300mg/kg (17300mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rabbit LD50 oral 19gm/kg (19000mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982.
rabbit LD50 oral 26800mg/kg (26800mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rabbit LD50 oral 28900mg/kg (28900mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rabbit LD50 oral 76gm/kg (76000mg/kg)   International Journal of Toxicology. Vol. 18(Suppl,
rabbit LD50 oral 76gm/kg (76000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rabbit LD50 skin > 20mL/kg (20mL/kg)   International Journal of Toxicology. Vol. 18(Suppl,
rabbit LD50 skin > 20gm/kg (20000mg/kg)   Dow Chemical Company Reports. Vol. MSD-1112,
rabbit LD50 skin > 20gm/kg (20000mg/kg)   Dow Chemical Company Reports. Vol. MSD-2202,
rabbit LD50 skin > 20gm/kg (20000mg/kg)   Dow Chemical Company Reports. Vol. MSD-96,
rabbit LD50 skin > 20gm/kg (20000mg/kg)   Dow Chemical Company Reports. Vol. MSD-2203,
rabbit LD50 skin > 20gm/kg (20000mg/kg)   Dow Chemical Company Reports. Vol. MSD-937,
rabbit LD50 skin > 20gm/kg (20000mg/kg)   Dow Chemical Company Reports. Vol. MSD-939,
rabbit LD50 skin > 20gm/kg (20000mg/kg)   Dow Chemical Company Reports. Vol. MSD-935,
rabbit LD50 skin > 20gm/kg (20000mg/kg)   Dow Chemical Company Reports. Vol. MSD-940,
rat LD oral > 4gm/kg (4000mg/kg)   Union Carbide Data Sheet. Vol. 9/25/1969,
rat LD50 intraperitoneal 6790mg/kg (6790mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 intraperitoneal 9gm/kg (9000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 intraperitoneal 9700mg/kg (9700mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3849, 1982.
rat LD50 intraperitoneal 9708mg/kg (9708mg/kg)   Proceedings of the European Society of Toxicology. Vol. 17, Pg. 351, 1976.
rat LD50 intraperitoneal 12600mg/kg (12600mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 intraperitoneal 14100mg/kg (14100mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3849, 1982.
rat LD50 intraperitoneal 15390mg/kg (15390mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 intraperitoneal 15570mg/kg (15570mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 intraperitoneal 16gm/kg (16000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 intraperitoneal 17gm/kg (17000mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 39, Pg. 349, 1950.
rat LD50 intraperitoneal 17700mg/kg (17700mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 intravenous 7130mg/kg (7130mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3849, 1982.
rat LD50 intravenous 7312mg/kg (7312mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976.
rat LD50 intravenous 7500mg/kg (7500mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3849, 1982.
rat LD50 intravenous 13gm/kg (13000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 oral 600mg/kg (600mg/kg)   Dow Chemical Company Reports. Vol. MSD-94,
rat LD50 oral 1054mg/kg (1054mg/kg)   Dow Chemical Company Reports. Vol. MSD-95,
rat LD50 oral > 4gm/kg (4000mg/kg)   Dow Chemical Company Reports. Vol. MSD-938,
rat LD50 oral 22gm/kg (22000mg/kg)   "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 747, 1969.
rat LD50 oral 27500mg/kg (27500mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 oral 28gm/kg (28000mg/kg)   Dow Chemical Company Reports. Vol. MSD-1112,
rat LD50 oral 30gm/kg (30000mg/kg)   Dow Chemical Company Reports. Vol. MSD-2203,
rat LD50 oral 30200mg/kg (30200mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 39, Pg. 349, 1950.
rat LD50 oral 31600mg/kg (31600mg/kg)   "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 747, 1969.
rat LD50 oral 31640mg/kg (31640mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 oral 32gm/kg (32000mg/kg)   Dow Chemical Company Reports. Vol. MSD-937,
rat LD50 oral 44200mg/kg (44200mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 oral 45gm/kg (45000mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982.
rat LD50 oral 50gm/kg (50000mg/kg)   "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 747, 1969.
rat LD50 oral > 50gm/kg (50000mg/kg)   Dow Chemical Company Reports. Vol. MSD-935,
rat LD50 oral 50gm/kg (50000mg/kg)   "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 747, 1969.
rat LD50 oral > 50gm/kg (50000mg/kg)   Dow Chemical Company Reports. Vol. MSD-940,
rat LD50 oral 50gm/kg (50000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 oral 51200mg/kg (51200mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 oral 51310mg/kg (51310mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 subcutaneous 16gm/kg (16000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 unreported 7800mg/kg (7800mg/kg)   United States Patent Document. Vol. #4767763,
rat LDLo intravenous 3mg/kg (3mg/kg)   Toxicology and Applied Pharmacology. Vol. 16, Pg. 442, 1970.
rat LDLo intravenous 22gm/kg (22000mg/kg) KIDNEY, URETER, AND BLADDER: HEMATURIA

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)		 Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 1087, 1973.