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Substance Name: Amcinonide [USAN:USP:INN:BAN:JAN]
RN: 51022-69-6
UNII: 423W026MA9
InChIKey: ILKJAFIWWBXGDU-MOGDOJJUSA-N

Classification Codes

  • Adrenal Cortex Hormones
  • Drug / Therapeutic Agent
  • Glucocorticoid
  • Glucocorticoids
  • Hormones
  • Hormones, Hormone Substitutes, and Hormone Antagonists

Molecular Formula

  • C28-H35-F-O7

Molecular Weight

  • 502.5755
 
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Names and Synonyms

Name of Substance

  • Amcinonide
  • Amcinonide [USAN:USP:INN:BAN:JAN]

Synonyms

  • 19alpha-Fluor-11beta,21-dihydroxy-16alpha,17alpha-(tetramethylen)methylendioxy-1,4-pregnadien-3,20-dion 21-acetat
  • 9-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with cyclopentanone, 21-acetate
  • Amcinonide
  • Amcinonido
  • Amcinonido [INN-Spanish]
  • Amcinonidum
  • Amcinonidum [INN-Latin]
  • CL 34699
  • CL-34699
  • Cyclocort
  • EINECS 256-915-2
  • Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-16,17-(cyclopentylidenebis(oxy))-9-fluoro-11-hydroxy-, (11beta,16alpha)-
  • Triamcinolonacetatcyclopentanonid
  • UNII-423W026MA9
  • Visderm

Systematic Names

  • 1,4-Pregnadiene-2,20-dione-16,17-cyclopentylidenedioxy-9-fluoro-11,21-dihydroxy-21-acetate
  • Amcinonide
  • Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-16,17-(cyclopentylidenebis(oxy))-9-fluoro-11-hydroxy-, (11beta,16alpha)-

Registry Numbers

CAS Registry Number

  • 51022-69-6

FDA UNII

  • 423W026MA9

System Generated Number

  • 0051022696

Structure Descriptors

InChI

InChI=1S/C28H35FO7/c1-16(30)34-15-22(33)28-23(35-26(36-28)9-4-5-10-26)13-20-19-7-6-17-12-18(31)8-11-24(17,2)27(19,29)21(32)14-25(20,28)3/h8,11-12,19-21,23,32H,4-7,9-10,13-15H2,1-3H3/t19-,20-,21-,23+,24-,25-,27-,28+/m0/s1

InChIKey

ILKJAFIWWBXGDU-MOGDOJJUSA-N

Smiles

CC(=O)OCC(=O)[C@@]12OC3(CCCC3)O[C@@H]1C[C@H]4[C@@H]5CCC6=CC(=O)C=C[C@]6(C)[C@@]5(F)[C@@H](O)C[C@]24C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 896mg/kg (896mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 637, 1982.
mouse LD50 oral > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. 6, Pg. APP-1, 1982.
mouse LD50 subcutaneous 143mg/kg (143mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 637, 1982.
rat LD50 intraperitoneal 243mg/kg (243mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 637, 1982.
rat LD50 oral > 2gm/kg (2000mg/kg)   Drugs in Japan Vol. 6, Pg. APP-1, 1982.
rat LD50 subcutaneous 145mg/kg (145mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 637, 1982.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 3.780 (none)   EST
Atmospheric OH Rate Constant 9.20E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.