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Substance Name: Choline chloride [INN]
RN: 67-48-1
UNII: 45I14D8O27
InChIKey: SGMZJAMFUVOLNK-UHFFFAOYSA-M

Note

  • A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.

Molecular Formula

  • C5-H14-N-O.Cl

Molecular Weight

  • 139.6246
 

Classification Code

  • Mutation Data

Names and Synonyms

Name of Substance

  • Choline chloride
  • Choline chloride [INN]

Synonyms

  • (2-Hydroxyethyl)trimethylammonium chloride
  • (beta-Hydroxyethyl)trimethylammonium chloride
  • 2-Hydroxy-N,N,N,-trimethylethanaminium chloride
  • 2-Hydroxy-N,N,N-trimethylethanaminium chloride
  • AI3-18302
  • Ammonium, (2-hydroxyethyl)trimethyl-, chloride
  • Bilineurin chloride
  • Biocolina
  • Biocoline
  • CCRIS 3716
  • Chloride de choline
  • Chloride de choline [French]
  • Chlorure de choline
  • Chlorure de choline [INN-French]
  • CHOLINE (CL)
  • Choline chlorhydrate
  • Choline chloride
  • Choline hydrochloride
  • Cholini chloridum
  • Cholini chloridum [INN-Latin]
  • Cholinium chloride
  • Cloruro de colina
  • Cloruro de colina [INN-Spanish]
  • Colina cloruro
  • Colina cloruro [DCIT]
  • EC 200-655-4
  • EINECS 200-655-4
  • Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, chloride
  • Hepacholine
  • Hormocline
  • HSDB 984
  • Lipotril
  • Luridin chloride
  • Neocolina
  • NSC 402838
  • Paresan
  • Trimethyl(2-hydroxyethyl)ammonium chloride
  • UNII-45I14D8O27

Systematic Names

  • (2-Hydroxyethyl)trimethylammonium chloride
  • Choline chloride
  • Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, chloride
  • Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, chloride (1:1)

Superlist Names

  • Choline chloride
  • Choline chloride solutions
  • Choline, chloride

Registry Numbers

CAS Registry Number

  • 67-48-1

FDA UNII

  • 45I14D8O27

Other Registry Numbers

  • 1643859-93-1
  • 2028303-08-2

Related Registry Number

  • 62-49-7 (Parent)

System Generated Number

  • 0000067481

Molecular Formulas

Molecular Formula

  • C5-H14-N-O.Cl

Molecular Formula Fragments

  • C5-H14-N-O
  • Cl
  • COMPONENT

Structure Descriptors

InChI

1S/C5H14NO.ClH/c1-6(2,3)4-5-7;/h7H,4-5H2,1-3H3;1H/q+1;/p-1

InChIKey

SGMZJAMFUVOLNK-UHFFFAOYSA-M

Smiles

C[N+](C)(C)CCO.[Cl-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 25mg/kg (25mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
dog LDLo intravenous 5mg/kg (5mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
frog LDLo unreported 1500mg/kg (1500mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 51, Pg. 281, 1942.
mouse LD50 intraperitoneal 320mg/kg (320mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 51, Pg. 281, 1942.
mouse LD50 intravenous 53mg/kg (53mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 1016, 1983.
mouse LD50 oral 3900mg/kg (3900mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 1016, 1983.
mouse LDLo subcutaneous 735mg/kg (735mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 6, Pg. 477, 1914/1915.
rabbit LDLo intraperitoneal 500mg/kg (500mg/kg) SENSE ORGANS AND SPECIAL SENSES: CORNEAL DAMAGE: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of Infectious Diseases. Vol. 42, Pg. 473, 1928.
rabbit LDLo intravenous 1100ug/kg (1.1mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Proceedings of the Society for Experimental Biology and Medicine. Vol. 51, Pg. 281, 1942.
rabbit LDLo rectal 1gm/kg (1000mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Proceedings of the Society for Experimental Biology and Medicine. Vol. 51, Pg. 281, 1942.
rabbit LDLo subcutaneous 1gm/kg (1000mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 51, Pg. 281, 1942.
rat LD50 intraperitoneal 450mg/kg (450mg/kg)   Indian Journal of Experimental Biology. Vol. 24, Pg. 91, 1986.
rat LD50 oral 3400mg/kg (3400mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: EXCITEMENT

SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE
Proceedings of the Society for Experimental Biology and Medicine. Vol. 58, Pg. 87, 1945.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 305 dec deg C   EXP
log P (octanol-water) -5.160 (none)   EST
Atmospheric OH Rate Constant 1.86E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.