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Substance Name: Batroxobin [INN:JAN]
RN: 9039-61-6
UNII: 47RYF40GA9

Note

  • A proteolytic enzyme obtained from the venom of fer-de-lance (Bothrops atrox). It is used as a plasma clotting agent for fibrinogen and for the detection of fibrinogen degradation products. The presence of heparin does not interfere with the clotting test. Hemocoagulase is a mixture containing batroxobin and factor X activator. EC 3.4.21.-.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Cardiovascular Agents
  • Coagulants
  • Drug / Therapeutic Agent
  • Fibrin Modulating Agents
  • Fibrinolytic Agents
  • Hematologic Agents
  • Hemostatics
  • Natural Product
  • Reproductive Effect
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Links to Resources

Names and Synonyms

Name of Substance

  • Batroxobin
  • Batroxobin [INN:JAN]

MeSH Heading

  • Batroxobin

Synonyms

  • Batroxobin
  • Batroxobina
  • Batroxobina [INN-Spanish]
  • Batroxobine
  • Batroxobine [INN-French]
  • Batroxobinum
  • Batroxobinum [INN-Latin]
  • Bothrops atrox blood-coagulation factor X activator
  • Bothrops venom proteinase
  • CCRIS 2737
  • Defibrase
  • Defibrase R
  • DF 521
  • DF-521
  • E.C. 3.4.21.29
  • EINECS 232-918-4
  • Hemostase
  • Reptilase
  • Reptilase R
  • UNII-47RYF40GA9

Systematic Names

  • Batroxobin
  • Proteinase, Bothrops atrox serine
  • Proteinase, bothrops venom
  • Thrombin-like enzyme obtained from the venom of Bothrops atrox.

Registry Numbers

CAS Registry Number

  • 9039-61-6

FDA UNII

  • 47RYF40GA9

Other Registry Numbers

  • 106039-45-6
  • 54182-64-8
  • 9073-75-0

System Generated Number

  • 0009039616

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 380ug/kg (0.38mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Oyo Yakuri. Pharmacometrics. Vol. 25, Pg. 339, 1983.
mouse LD50 intravenous 384ug/kg (0.384mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Oyo Yakuri. Pharmacometrics. Vol. 25, Pg. 339, 1983.
rat LD50 intravenous 210ug/kg (0.21mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Oyo Yakuri. Pharmacometrics. Vol. 25, Pg. 339, 1983.