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Substance Name: Candicidin [USAN:USP:INN:BAN]
RN: 1403-17-4
UNII: 48N2IYJ202
InChIKey: OPGSFDUODIJJGF-JBUZINEHSA-N

Note

  • Mixture of antifungal heptaene macrolides from Streptomyces griseus or Actinomyces levoris used topically in candidiasis. The antibiotic complex is composed of candicidins A, B, C, and D, of which D is the major component.

Molecular Formula

  • C63-H85-N21-O19

Molecular Weight

  • 1109.3086
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antifungal
  • Antifungal Agents
  • Drug / Therapeutic Agent
  • Natural Product
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Candicidin
  • Candicidin [USAN:USP:INN:BAN]

MeSH Heading

  • Candicidin

Synonyms

  • Candeptin
  • Candicidin
  • Candicidina
  • Candicidina [INN-Spanish]
  • Candicidine
  • Candicidine [INN-French]
  • Candicidinum
  • Candicidinum [INN-Latin]
  • Candimon
  • Candizidin
  • Candizidin [German]
  • EINECS 215-763-7
  • Levorina
  • Levorina [INN-Spanish]
  • Levorine
  • Levorine [INN-French]
  • Levorinum
  • Levorinum [INN-Latin]
  • NSC 94219
  • UNII-48N2IYJ202
  • Vanobid

Systematic Name

  • Candicidin

Registry Numbers

CAS Registry Number

  • 1403-17-4

FDA UNII

  • 48N2IYJ202

System Generated Number

  • 0001403174

Structure Descriptors

InChI

InChI=1S/C59H84N2O18/c1-35-18-15-13-11-9-7-5-6-8-10-12-14-16-21-47(78-59-56(74)54(61)55(73)38(4)77-59)33-51(71)53(58(75)76)50(70)31-46(67)30-45(66)29-44(65)28-43(64)27-41(62)19-17-20-42(63)32-52(72)79-57(35)37(3)26-36(2)48(68)34-49(69)39-22-24-40(60)25-23-39/h5-16,18,21-25,35-38,43-45,47-48,50-51,53-57,59,64-66,68,70-71,73-74H,17,19-20,26-34,60-61H2,1-4H3,(H,75,76)/b6-5+,9-7+,10-8+,13-11+,14-12+,18-15+,21-16+/t35?,36?,37?,38-,43?,44?,45?,47?,48?,50?,51?,53?,54+,55-,56+,57?,59?/m1/s1

InChIKey

OPGSFDUODIJJGF-JBUZINEHSA-N

Smiles

CC(CC(C)C1OC(=O)CC(=O)CCCC(=O)CC(O)CC(O)CC(O)CC(=O)CC(O)C(C(O)CC(OC2O[C@H](C)[C@@H](O)[C@H](N)[C@@H]2O)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\C1C)C(=O)O)C(O)CC(=O)c3ccc(N)cc3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 14mg/kg (14mg/kg)   Antibiotics Annual. Vol. 2, Pg. 980, 1954/1955.
mouse LD50 oral 1gm/kg (1000mg/kg)   Antibiotiki. Vol. 14, Pg. 932, 1969.
mouse LD50 subcutaneous 160mg/kg (160mg/kg)   Progress in Medical Chemistry. Vol. 14, Pg. 105, 1977.
rat LD50 oral 2900mg/kg (2900mg/kg)   Antibiotiki. Vol. 14, Pg. 932, 1969.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 3.030 (none)   EST
Atmospheric OH Rate Constant 2.62E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.