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Substance Name: Benzydamine [INN:BAN]
RN: 642-72-8
UNII: 4O21U048EF
InChIKey: CNBGNNVCVSKAQZ-UHFFFAOYSA-N

Note

  • A benzyl-indazole having analgesic, antipyretic, and anti-inflammatory effects. It is used to reduce post-surgical and post-traumatic pain and edema and to promote healing. It is also used topically in treatment of RHEUMATIC DISEASES and INFLAMMATION of the mouth and throat.

Molecular Formula

  • C19-H23-N3-O

Molecular Weight

  • 309.411
 

Classification Codes

  • Anti-Inflammatory Agents
  • Drug / Therapeutic Agent
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Names and Synonyms

Results Name

  • Benzydamine [INN:BAN]

Name of Substance

  • Benzydamine
  • Benzydamine [INN:BAN]

MeSH Heading

  • Benzydamine

Synonyms

  • 1-Benzyl-3-(3-(dimethylamino)propoxy)-1H-indazole
  • 5-23-11-00248 (Beilstein Handbook Reference)
  • Bencidamina
  • Bencidamina [INN-Spanish]
  • Benzidamina
  • Benzidamina [DCIT]
  • Benzidamine
  • Benzydamine
  • Benzydaminum
  • Benzydaminum [INN-Latin]
  • BRN 0896536
  • C 1523
  • EINECS 211-388-8
  • UNII-4O21U048EF

Systematic Names

  • 1-Propanamine, N,N-dimethyl-3-((1-(phenylmethyl)-1H-indazol-3-yl)oxy)-
  • 1H-Indazole, 1-benzyl-3-(3-(dimethylamino)propoxy)-
  • Benzydamine

Registry Numbers

CAS Registry Number

  • 642-72-8

FDA UNII

  • 4O21U048EF

Related Registry Number

  • 132-69-4 (mono-hydrochloride)

System Generated Number

  • 0000642728

Structure Descriptors

InChI

InChI=1S/C19H23N3O/c1-21(2)13-8-14-23-19-17-11-6-7-12-18(17)22(20-19)15-16-9-4-3-5-10-16/h3-7,9-12H,8,13-15H2,1-2H3

InChIKey

CNBGNNVCVSKAQZ-UHFFFAOYSA-N

Smiles

CN(C)CCCOc1nn(Cc2ccccc2)c3ccccc13

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 109mg/kg (109mg/kg)   Journal of Medicinal Chemistry. Vol. 15, Pg. 471, 1972.
mouse LD50 intravenous 25mg/kg (25mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR
Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1285, 1972.
mouse LD50 oral 460mg/kg (460mg/kg) BEHAVIORAL: ATAXIA

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 1266, 1973.
mouse LD50 subcutaneous 445mg/kg (445mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1285, 1972.
rat LD50 oral 950mg/kg (950mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 41, 1978.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 4.210 (none)   EST
Atmospheric OH Rate Constant 2.96E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.