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Substance Name: Benzbromarone [USAN:INN:BAN]
RN: 3562-84-3
UNII: 4POG0RL69O
InChIKey: WHQCHUCQKNIQEC-UHFFFAOYSA-N

Note

  • Uricosuric that acts by increasing uric acid clearance. It is used in the treatment of gout.

Molecular Formula

  • C17-H12-Br2-O3

Molecular Weight

  • 424.0868
 

Classification Codes

  • Antirheumatic Agents
  • Drug / Therapeutic Agent
  • Gout Suppressants
  • Renal Agents
  • Reproductive Effect
  • Uricosuric
  • Uricosuric Agents
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Names and Synonyms

Name of Substance

  • Benzbromarone
  • Benzbromarone [USAN:INN:BAN]

MeSH Heading

  • Benzbromarone

Synonyms

  • (2-Ethyl-3-benzofuranyl)-(3,5-dibrom-4-hydroxyphenyl)keton
  • 2-Ethyl-3-(3,5-dibrom-4-hydroxybenzoyl)benzofuran
  • 3,5-Dibromo-4-hydroxyphenyl-2-ethyl-3-benzofuranyl ketone
  • 5-18-02-00335 (Beilstein Handbook Reference)
  • Azubromaron
  • Benzbromaron
  • Benzbromarone
  • Benzbromaronum
  • Benzbromaronum [INN-Latin]
  • Benzobromarona
  • Benzobromarona [INN-Spanish]
  • Benzofuran, 3-(3,5-dibromo-4-hydroxybenzoyl)-2-ethyl-
  • BRN 0273668
  • Desuric
  • EINECS 222-630-7
  • Exurate
  • Harolan
  • Hipurik
  • L 2214
  • L 2214-Labaz
  • L-2214
  • L2214
  • L2214-Labaz
  • Minuric
  • MJ 10061
  • Narcaricin
  • Normurat
  • NSC 85433
  • UNII-4POG0RL69O
  • Uricovac
  • Urinorm

Systematic Names

  • Benzbromarone
  • Ketone, 3,5-dibromo-4-hydroxyphenyl 2-ethyl-3-benzofuranyl
  • Methanone, (3,5-dibromo-4-hydroxyphenyl)(2-ethyl-3-benzofuranyl)-

Registry Numbers

CAS Registry Number

  • 3562-84-3

FDA UNII

  • 4POG0RL69O

System Generated Number

  • 0003562843

Structure Descriptors

InChI

1S/C17H12Br2O3/c1-2-13-15(10-5-3-4-6-14(10)22-13)16(20)9-7-11(18)17(21)12(19)8-9/h3-8,21H,2H2,1H3

InChIKey

WHQCHUCQKNIQEC-UHFFFAOYSA-N

Smiles

c1(c2c(oc1CC)cccc2)C(=O)c1cc(c(c(c1)Br)O)Br

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 146mg/kg (146mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED
Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 341, 1972.
mouse LD50 intravenous 77mg/kg (77mg/kg) KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 341, 1972.
mouse LD50 oral 618mg/kg (618mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 232, 1979.
mouse LD50 subcutaneous 4120mg/kg (4120mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 232, 1979.
rat LD50 intraperitoneal 239mg/kg (239mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 232, 1979.
rat LD50 oral 248mg/kg (248mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 232, 1979.
rat LD50 subcutaneous 1230mg/kg (1230mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 232, 1979.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 151 deg C   EXP
log P (octanol-water) 6.030 (none)   EST
Atmospheric OH Rate Constant 4.17E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.