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Substance Name: Histidine [USAN:INN]
RN: 71-00-1
UNII: 4QD397987E
InChIKey: HNDVDQJCIGZPNO-YFKPBYRVSA-N

Note

  • An essential amino acid that is required for the production of HISTAMINE.

Classification Codes

  • Amino Acid
  • Mutation Data

Molecular Formula

  • C6-H9-N3-O2

Molecular Weight

  • 155.156
 

Names and Synonyms

Name of Substance

  • (L)-Histidine
  • Histidine
  • Histidine [USAN:INN]

MeSH Heading

  • Histidine

Synonyms

  • (S)-2-Amino-3-(4-imidazolyl)propionsaeure
  • (S)-4-(2-Amino-2-carboxyethyl)imidazole
  • (S)-alpha-Amino-1H-imidazole-4-propanoic acid
  • 1H-Imidazole-4-alanine, (S)-
  • 1H-Imidazole-4-propanoic acid, alpha-amino-, (S)-
  • 4-(2-Amino-2-carboxyethyl)imidazole
  • AI3-26558
  • alpha-Amino-1H-imidazole-4-propionic acid, (S)-
  • alpha-Amino-4(or 5)-imidazolepropionic acid
  • Anti-rheuma
  • EINECS 200-745-3
  • FEMA No. 3694
  • Glyoxaline-5-alanine
  • HIS
  • Histidina
  • Histidina [INN-Spanish]
  • Histidine
  • Histidine (VAN)
  • Histidinum
  • Histidinum [INN-Latin]
  • HSDB 1810
  • Istidina
  • L-Alanine, 3-(1H-imidazol-4-yl)-
  • L-beta-(4-Imidazolyl)-alpha-alanin
  • L-beta-(4-Imidazolyl)alanin
  • L-Histidine
  • NSC 137773
  • S-Histidine
  • UNII-4QD397987E

Systematic Names

  • Histidine
  • L-Histidine

Superlist Name

  • Histidine, L-

Registry Numbers

CAS Registry Number

  • 71-00-1

FDA UNII

  • 4QD397987E

Other Registry Numbers

  • 150-35-6
  • 155304-24-8
  • 35479-49-3
  • 35558-59-9
  • 45955-20-2
  • 54166-13-1
  • 7006-35-1
  • 736075-03-9

System Generated Number

  • 0000071001

Structure Descriptors

InChI

1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1

InChIKey

HNDVDQJCIGZPNO-YFKPBYRVSA-N

Smiles

c1(C[C@@H](C(O)=O)N)c[nH]cn1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal > 10gm/kg (10000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 1253, 1981.
mouse LD50 intravenous > 2gm/kg (2000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 1253, 1981.
mouse LD50 oral > 15gm/kg (15000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 1253, 1981.
mouse LD50 subcutaneous > 10gm/kg (10000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 1253, 1981.
rat LD50 intraperitoneal > 8gm/kg (8000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 1253, 1981.
rat LD50 intravenous > 2gm/kg (2000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 1253, 1981.
rat LD50 oral > 15gm/kg (15000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 1253, 1981.
rat LD50 subcutaneous > 10gm/kg (10000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 1253, 1981.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 287 dec deg C   EXP
pKa Dissociation Constant 2.76 (none) 0 EXP
log P (octanol-water) -3.32E+00 (none)   EXP
Water Solubility 4.56E+04 mg/L 25 EXP
Vapor Pressure 5.99E-09 mm Hg 25 EST
Henry's Law Constant 8.40E-14 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.29E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.