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Substance Name: Piritramide [INN:BAN:DCF]
RN: 302-41-0
UNII: 4RP92LYZ2F
InChIKey: IHEHEFLXQFOQJO-UHFFFAOYSA-N
Note
- A diphenylpropylamine with intense narcotic analgesic activity of long duration. It is a derivative of MEPERIDINE with similar activity and usage.
Molecular Formula
- C27-H34-N4-O
Molecular Weight
- 430.593
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Analgesics
- Analgesics, Opioid
- Central Nervous System Agents
- Central Nervous System Depressants
- Drug / Therapeutic Agent
- Narcotics
- Peripheral Nervous System Agents
- Sensory System Agents
Superlist Classification Code
- DEA Schedule I
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Names and Synonyms
Name of Substance
- Pirinitramide
- Piritramide [INN:BAN:DCF]
MeSH Heading
- Pirinitramide
Synonyms
- 1'-(3-Cyano-3,3-diphenylpropyl)(1,4'-bipiperidine)-4'-carboxamide
- 1'-(3-Cyano-3,3-diphenylpropyl)-(1,4'-bipiperidine)-4'-carboxamide
- 2,2-Diphenyl-4-(4-piperidino-4-carbamoylpiperidino)butyronitrile
- 5-22-13-00539 (Beilstein Handbook Reference)
- BRN 0501362
- Dipidolor
- Dipiritramide
- EINECS 206-124-3
- Piridolan
- Pirinitramide
- Piritramida
- Piritramida [INN-Spanish]
- Piritramide
- Piritramidum
- Piritramidum [INN-Latin]
- R 3365
- UNII-4RP92LYZ2F
Systematic Names
- (1,4'-Bipiperidine)-4'-carboxamide, 1'-(3-cyano-3,3-diphenylpropyl)-
- 1'-(3-Cyano-3,3-diphenylpropyl)-(1,4'-bipiperidine)-4'-carboxamide
- Piritramide
Superlist Names
- DEA No. 9642
- Piritramide
Registry Numbers
CAS Registry Number
- 302-41-0
FDA UNII
- 4RP92LYZ2F
System Generated Number
- 0000302410
Structure Descriptors
InChI
InChI=1S/C27H34N4O/c28-22-26(23-10-4-1-5-11-23,24-12-6-2-7-13-24)14-19-30-20-15-27(16-21-30,25(29)32)31-17-8-3-9-18-31/h1-2,4-7,10-13H,3,8-9,14-21H2,(H2,29,32)InChIKey
IHEHEFLXQFOQJO-UHFFFAOYSA-NSmiles
NC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LD50 | subcutaneous | > 10mg/kg (10mg/kg) | Journal of Pharmacy and Pharmacology. Vol. 13, Pg. 513, 1961. | |
dog | LD50 | subcutaneous | > 40mg/kg (40mg/kg) | Journal of Pharmacy and Pharmacology. Vol. 13, Pg. 513, 1961. | |
monkey | LD50 | subcutaneous | > 10mg/kg (10mg/kg) | Journal of Pharmacy and Pharmacology. Vol. 13, Pg. 513, 1961. | |
mouse | LD50 | intravenous | 30700ug/kg (30.7mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Farmakologiya i Toksikologiya Vol. 54(5), Pg. 59, 1991. |
mouse | LD50 | oral | > 320mg/kg (320mg/kg) | Journal of Pharmacy and Pharmacology. Vol. 13, Pg. 513, 1961. | |
mouse | LD50 | subcutaneous | 280mg/kg (280mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Journal of Pharmacy and Pharmacology. Vol. 13, Pg. 513, 1961. |
rat | LD50 | intravenous | 13mg/kg (13mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Journal of Pharmacy and Pharmacology. Vol. 13, Pg. 513, 1961. |
rat | LD50 | oral | 320mg/kg (320mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Journal of Pharmacy and Pharmacology. Vol. 13, Pg. 513, 1961. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 149.5 | deg C | EXP | |
log P (octanol-water) | 3.91 | (none) | EXP | |
Water Solubility | 0.491 | mg/L | 25 | EST |
Vapor Pressure | 7.13E-14 | mm Hg | 25 | EST |
Henry's Law Constant | 2.78E-19 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 2.11E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.