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Substance Name: Kebuzone [INN]
RN: 853-34-9
UNII: 4VD83UL6Y6
InChIKey: LGYTZKPVOAIUKX-UHFFFAOYSA-N
Note
- Proposed antirheumatic agent.
Molecular Formula
- C19-H18-N2-O3
Molecular Weight
- 322.3622
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Drug / Therapeutic Agent
- Peripheral Nervous System Agents
- Sensory System Agents
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Names and Synonyms
Name of Substance
- Kebuzone
- Kebuzone [INN]
Synonyms
- 1,2-Diphenyl-4-(3'-oxobutyl)-3,5-dioxopyrazolidine
- 1,2-Diphenyl-4-(gamma-ketobutyl)-3,5-pyrazolidinedione
- 4-(3-Oxobutyl)-1,2-diphenyl-3,5-pyrazolidinedione
- 5-24-09-00131 (Beilstein Handbook Reference)
- BRN 0308507
- Chebutan
- Chepirol
- Chetazolidin
- Chetil
- Copirene
- EINECS 212-715-7
- Hichillos
- Kebuzone
- Kebuzonum
- Kebuzonum [INN-Latin]
- Keobutane-jade
- Ketason
- Ketazone
- Ketophenylbutazone
- Ketophenylbutazonum
- KPB
- Pecnon
- Quebuzona
- Quebuzona [INN-Spanish]
- Recheton
- UNII-4VD83UL6Y6
Systematic Names
- 3,5-Pyrazolidinedione, 1,2-diphenyl-4-(3-oxobutyl)-
- 4-(3-Oxobutyl)-1,2-diphenyl-3,5-pyrazolidinedione
- Kebuzone
Registry Numbers
CAS Registry Number
- 853-34-9
FDA UNII
- 4VD83UL6Y6
System Generated Number
- 0000853349
Structure Descriptors
InChI
InChI=1S/C19H18N2O3/c1-14(22)12-13-17-18(23)20(15-8-4-2-5-9-15)21(19(17)24)16-10-6-3-7-11-16/h2-11,17H,12-13H2,1H3InChIKey
LGYTZKPVOAIUKX-UHFFFAOYSA-NSmiles
CC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 662mg/kg (662mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 390, 1969. | |
mouse | LD50 | intravenous | 580mg/kg (580mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 390, 1969. | |
mouse | LD50 | oral | 750mg/kg (750mg/kg) | Cesko-Slovenska Farmacie. Vol. 22, Pg. 66, 1973. | |
mouse | LD50 | parenteral | 650mg/kg (650mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 1339, 1966. | |
mouse | LD50 | subcutaneous | 620mg/kg (620mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 390, 1969. | |
rat | LD50 | intraperitoneal | 683mg/kg (683mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 390, 1969. | |
rat | LD50 | intravenous | 315mg/kg (315mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 229, 1958. |
rat | LD50 | oral | 720mg/kg (720mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 229, 1958. |
rat | LD50 | subcutaneous | 750mg/kg (750mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 229, 1958. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
log P (octanol-water) | 1.470 | (none) | EST | |
Water Solubility | 174 | mg/L | 20 | EXP |
Atmospheric OH Rate Constant | 4.09E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.