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Substance Name: Kebuzone [INN]
RN: 853-34-9
UNII: 4VD83UL6Y6
InChIKey: LGYTZKPVOAIUKX-UHFFFAOYSA-N

Note

  • Proposed antirheumatic agent.

Molecular Formula

  • C19-H18-N2-O3

Molecular Weight

  • 322.3622
 

Classification Codes

  • Analgesics
  • Analgesics, Non-Narcotic
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antirheumatic Agents
  • Drug / Therapeutic Agent
  • Peripheral Nervous System Agents
  • Sensory System Agents
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Names and Synonyms

Name of Substance

  • Kebuzone
  • Kebuzone [INN]

Synonyms

  • 1,2-Diphenyl-4-(3'-oxobutyl)-3,5-dioxopyrazolidine
  • 1,2-Diphenyl-4-(gamma-ketobutyl)-3,5-pyrazolidinedione
  • 4-(3-Oxobutyl)-1,2-diphenyl-3,5-pyrazolidinedione
  • 5-24-09-00131 (Beilstein Handbook Reference)
  • BRN 0308507
  • Chebutan
  • Chepirol
  • Chetazolidin
  • Chetil
  • Copirene
  • EINECS 212-715-7
  • Hichillos
  • Kebuzone
  • Kebuzonum
  • Kebuzonum [INN-Latin]
  • Keobutane-jade
  • Ketason
  • Ketazone
  • Ketophenylbutazone
  • Ketophenylbutazonum
  • KPB
  • Pecnon
  • Quebuzona
  • Quebuzona [INN-Spanish]
  • Recheton
  • UNII-4VD83UL6Y6

Systematic Names

  • 3,5-Pyrazolidinedione, 1,2-diphenyl-4-(3-oxobutyl)-
  • 4-(3-Oxobutyl)-1,2-diphenyl-3,5-pyrazolidinedione
  • Kebuzone

Registry Numbers

CAS Registry Number

  • 853-34-9

FDA UNII

  • 4VD83UL6Y6

System Generated Number

  • 0000853349

Structure Descriptors

InChI

InChI=1S/C19H18N2O3/c1-14(22)12-13-17-18(23)20(15-8-4-2-5-9-15)21(19(17)24)16-10-6-3-7-11-16/h2-11,17H,12-13H2,1H3

InChIKey

LGYTZKPVOAIUKX-UHFFFAOYSA-N

Smiles

CC(=O)CCC1C(=O)N(N(C1=O)c2ccccc2)c3ccccc3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 662mg/kg (662mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 390, 1969.
mouse LD50 intravenous 580mg/kg (580mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 390, 1969.
mouse LD50 oral 750mg/kg (750mg/kg)   Cesko-Slovenska Farmacie. Vol. 22, Pg. 66, 1973.
mouse LD50 parenteral 650mg/kg (650mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 1339, 1966.
mouse LD50 subcutaneous 620mg/kg (620mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 390, 1969.
rat LD50 intraperitoneal 683mg/kg (683mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 390, 1969.
rat LD50 intravenous 315mg/kg (315mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 229, 1958.
rat LD50 oral 720mg/kg (720mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 229, 1958.
rat LD50 subcutaneous 750mg/kg (750mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 229, 1958.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 1.470 (none)   EST
Water Solubility 174 mg/L 20 EXP
Atmospheric OH Rate Constant 4.09E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.