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Substance Name: Oxprenolol [INN:BAN]
RN: 6452-71-7
UNII: 519MXN9YZR
InChIKey: CEMAWMOMDPGJMB-UHFFFAOYSA-N

Note

  • A beta-adrenergic antagonist used in the treatment of hypertension, angina pectoris, arrhythmias, and anxiety.

Molecular Formula

  • C15-H23-N-O3

Molecular Weight

  • 265.3507
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic Antagonists
  • Adrenergic beta-Antagonists
  • Anti-Anxiety Agents
  • Anti-Arrhythmia Agents
  • Antihypertensive Agents
  • Autonomic Agents
  • Cardiovascular Agents
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Human Data
  • Neurotransmitter Agents
  • Peripheral Nervous System Agents
  • Psychotropic Drugs
  • Sympatholytics
  • Tranquilizing Agents
  • Vasodilator Agents
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Names and Synonyms

Name of Substance

  • Oxprenolol
  • Oxprenolol [INN:BAN]

MeSH Heading

  • Oxprenolol

Synonyms

  • (+-)-Oxprenolol
  • 1-((1-Methylethyl)amino)-3-(2-(2-propenyloxy)phenoxy)-2-propanol
  • 1-(Isopropylamino)-2-hydroxy-3-(o-(allyloxy)phenoxy)propane
  • 1-(o-(Allyloxy)phenoxy)-3-(isopropylamino)-2-propanol
  • 2-Propanol, 1-((1-methylethyl)amino)-3-(2-(2-propenyloxy)phenoxy)-
  • CCRIS 4201
  • Coretal
  • dl-Oxprenolol
  • EINECS 229-257-9
  • EINECS 245-359-6
  • Osprenololo
  • Osprenololo [DCIT]
  • Oxprenolol
  • Oxprenolol, dl-
  • Oxprenololum
  • Oxprenololum [INN-Latin]
  • UNII-519MXN9YZR

Systematic Names

  • (1)-1-(o-(Allyloxy)phenoxy)-3-(isopropylamino)propan-2-ol
  • 2-Propanol, 1-((1-methylethyl)amino)-3-(2-(2-propenyloxy)phenoxy)-
  • 2-Propanol, 1-(2-allyloxyphenoxy)-3-(isopropylamino)-
  • Oxprenolol

Registry Numbers

CAS Registry Number

  • 6452-71-7

FDA UNII

  • 519MXN9YZR

Other Registry Numbers

  • 22972-98-1
  • 71186-75-9

Related Registry Number

  • 6452-73-9 (hydrochloride)

System Generated Number

  • 0006452717

Structure Descriptors

InChI

InChI=1S/C15H23NO3/c1-4-9-18-14-7-5-6-8-15(14)19-11-13(17)10-16-12(2)3/h4-8,12-13,16-17H,1,9-11H2,2-3H3

InChIKey

CEMAWMOMDPGJMB-UHFFFAOYSA-N

Smiles

CC(C)NCC(O)COc1ccccc1OCC=C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo oral 50mg/kg (50mg/kg) CARDIAC: PULSE RATE

CARDIAC: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 British Medical Journal. Vol. 1, Pg. 776, 1977.
mouse LD50 intraperitoneal 170mg/kg (170mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Polish Journal of Pharmacology and Pharmacy. Vol. 25, Pg. 145, 1973.
mouse LD50 intravenous 20mg/kg (20mg/kg)   United States Patent Document. Vol. #5326774,
mouse LD50 oral 375mg/kg (375mg/kg)   United States Patent Document. Vol. #5326774,

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 2.1 (none)   EXP
Water Solubility 3180 mg/L 25 EST
Vapor Pressure 3.12E-07 mm Hg 25 EST
Henry's Law Constant 6.35E-13 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.60E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.