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Substance Name: Mafenide [USAN:INN:BAN]
RN: 138-39-6
UNII: 58447S8P4L
InChIKey: TYMRLRRVMHJFTF-UHFFFAOYSA-N

Note

  • A sulfonamide that inhibits the enzyme CARBONIC ANHYDRASE and is used as a topical anti-bacterial agent, especially in burn therapy.

Molecular Formula

  • C7-H10-N2-O2-S

Molecular Weight

  • 186.234
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Anti-Infective Agents, Local
  • Antibacterial
  • Carbonic Anhydrase Inhibitors
  • Enzyme Inhibitors
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Names and Synonyms

Name of Substance

  • Mafenide
  • Mafenide [USAN:INN:BAN]

MeSH Heading

  • Mafenide

Synonyms

  • 4-(Aminomethyl)benzenesulfonamide
  • alpha-Amino-p-toluenesulfonamide
  • Ambamide
  • Benzamsulfonamide
  • EINECS 205-326-9
  • Emilene
  • Homonal
  • Homosul
  • Homosulfaminum
  • Homosulfanilamide
  • Mafenida
  • Mafenida [INN-Spanish]
  • Mafenide
  • Mafenidum
  • Mafenidum [INN-Latin]
  • Malfamin
  • Maphenid
  • Maphenide
  • Marprontil
  • Mesudin
  • Mesudrin
  • Neofamid
  • NSC 34632
  • p-(Aminomethyl)benzenesulfonamide
  • Paramenyl
  • Septicid
  • Sulfamylon
  • UNII-58447S8P4L

Systematic Names

  • Benzenesulfonamide, 4-(aminomethyl)-
  • Mafenide
  • p-Toluenesulfonamide, alpha-amino-

Registry Numbers

CAS Registry Number

  • 138-39-6

FDA UNII

  • 58447S8P4L

System Generated Number

  • 0000138396

Structure Descriptors

InChI

InChI=1S/C7H10N2O2S/c8-5-6-1-3-7(4-2-6)12(9,10)11/h1-4H,5,8H2,(H2,9,10,11)

InChIKey

TYMRLRRVMHJFTF-UHFFFAOYSA-N

Smiles

NCc1ccc(cc1)S(=O)(=O)N

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) -0.550 (none)   EST
Water Solubility 3.90E+05 mg/L 20 EXP
Atmospheric OH Rate Constant 3.07E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.