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Substance Name: Nefazodone [INN:BAN]
RN: 83366-66-9
UNII: 59H4FCV1TF
InChIKey: VRBKIVRKKCLPHA-UHFFFAOYSA-N

Note

  • May be useful as an opiate adjunct.

Molecular Formula

  • C25-H32-Cl-N5-O2

Molecular Weight

  • 470.014
 

Classification Codes

  • Antidepressive Agents
  • Antidepressive Agents, Second-Generation
  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Membrane Transport Modulators
  • Neurotransmitter Agents
  • Neurotransmitter Uptake Inhibitors
  • Psychotropic Drugs
  • Serotonin 5-HT2 Receptor Antagonists
  • Serotonin Agents
  • Serotonin and Noradrenaline Reuptake Inhibitors
  • Serotonin Antagonists

Names and Synonyms

Name of Substance

  • Nefazodone
  • Nefazodone [INN:BAN]

Synonyms

  • 1-(3-(4-(3-Chlorpheyl-1-piperazinylpropyl)-3-ethyl-4,5-dihydro-4-(2-phenoxyethyl)-1,2,4-triazol-5-on
  • 1-(3-(4-(m-Chlorophenyl)-1-piperazinyl)propyl)-3-ethyl-4-(2-phenoxyethyl)-delta2-1,2,4-triazolin-5-one
  • HSDB 8411
  • Nefazodona
  • Nefazodona [Spanish]
  • Nefazodone
  • Nefazodonum
  • Nefazodonum [Latin]
  • UNII-59H4FCV1TF

Systematic Names

  • 3H-1,2,4-Triazol-3-one, 2,4-dihydro-2-3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-5-ethyl-4-(2-phenoxyethyl)-
  • 3H-1,2,4-Triazol-3-one, 2-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-

Registry Numbers

CAS Registry Number

  • 83366-66-9

FDA UNII

  • 59H4FCV1TF

Related Registry Number

  • 82752-99-6 (hydrochloride)

System Generated Number

  • 0083366669

Structure Descriptors

InChI

InChI=1S/C25H32ClN5O2/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22/h3-6,8-11,20H,2,7,12-19H2,1H3

InChIKey

VRBKIVRKKCLPHA-UHFFFAOYSA-N

Smiles

CCC1=NN(CCCN2CCN(CC2)c3cccc(Cl)c3)C(=O)N1CCOc4ccccc4

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 40mg/kg/2W-I (40mg/kg) PERIPHERAL NERVE AND SENSATION: PARESTHESIS Journal of Clinical Psychiatry. Vol. 61, Pg. 216, 2000.
women TDLo oral 28mg/kg/1W-I (28mg/kg) BEHAVIORAL: ALTERATION OF OPERANT CONDITIONING

BEHAVIORAL: TOXIC PSYCHOSIS

BEHAVIORAL: EXCITEMENT
American Journal of Psychiatry. Vol. 154, Pg. 578, 1997.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 83.5 deg C   EXP
log P (octanol-water) 5.000 (none)   EST
Atmospheric OH Rate Constant 2.74E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.