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Substance Name: Vincristine [INN:BAN]
RN: 57-22-7
UNII: 5J49Q6B70F
InChIKey: OGWKCGZFUXNPDA-CFWMRBGOSA-N
Note
- An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.).
Molecular Formula
- C46-H56-N4-O10
Molecular Weight
- 824.9664
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Antimitotic Agents
- Antineoplastic Agents
- Antineoplastic Agents, Phytogenic
- Drug / Therapeutic Agent
- Human Data
- Mitosis Modulators
- Mutation Data
- Natural Product
- Reproductive Effect
- Skin / Eye Irritant
- Tubulin Modulators
- Tumor Data
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Names and Synonyms
Name of Substance
- Vincristine
- Vincristine [INN:BAN]
MeSH Heading
- Vincristine
Synonyms
- 22-Oxovincaleukoblastine
- CCRIS 5763
- Citomid
- EINECS 200-318-1
- Farmistin
- HSDB 3199
- LCR
- Leurocristine
- NCI-C04864
- NSC 67574
- NSC-67574
- Onco TCS
- Oncovine
- Onkocristin
- UNII-5J49Q6B70F
- VCR
- Vincaleukoblastine, 22-oxo-
- Vincristina
- Vincristina [DCIT]
- Vincristine
- Vincristinum
- Vincristinum [INN-Latin]
- Vincrystine
- Vinkristin
Systematic Names
- Leurocristine
- Vincaleukoblastine, 22-oxo-
- Vincristine
Registry Numbers
CAS Registry Number
- 57-22-7
FDA UNII
- 5J49Q6B70F
Other Registry Number
- 28379-27-3
System Generated Number
- 0000057227
Structure Descriptors
InChI
InChI=1S/C46H56N4O10/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3/t28-,37-,38+,39+,42-,43+,44+,45-,46-/m0/s1InChIKey
OGWKCGZFUXNPDA-CFWMRBGOSA-NSmiles
CC[C@]1(O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
child | LDLo | parenteral | 8290ug/kg (8.29mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: DECREASED MOTILITY OR CONSTIPATION BLOOD: CHANGES IN CELL COUNT (UNSPECIFIED) | Archives of Disease in Childhood. Vol. 51, Pg. 289, 1976. |
child | TDLo | intravenous | 500ug/kg (0.5mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ANOREXIA (HUMAN GASTROINTESTINAL: NAUSEA OR VOMITING | Journal of Pediatrics. Vol. 81, Pg. 90, 1972. |
hamster | LD10 | parenteral | 350ug/kg (0.35mg/kg) | Journal of Surgical Oncology. Vol. 15, Pg. 355, 1980. | |
human | TDLo | intravenous | 120ug/kg/8W (0.12mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) | British Medical Journal. Vol. 1, Pg. 1251, 1977. |
mouse | LD50 | intraperitoneal | 1300ug/kg (1.3mg/kg) | Cancer Treatment Reports. Vol. 65, Pg. 1049, 1981. | |
mouse | LD50 | intravenous | 3mg/kg (3mg/kg) | United States Patent Document. Vol. #4279915, | |
mouse | LD50 | unreported | 5800ug/kg (5.8mg/kg) | Cancer Research. Vol. 46, Pg. 2703, 1986. | |
mouse | LDLo | intratracheal | 1200ug/kg (1.2mg/kg) | Toxicology Letters. Vol. 30, Pg. 63, 1986. | |
rat | LD50 | intraperitoneal | 1250ug/kg (1.25mg/kg) | Advances in Teratology. Vol. 3, Pg. 181, 1968. | |
rat | LD50 | intravenous | 1mg/kg (1mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Journal of Medicinal Chemistry. Vol. 28, Pg. 1079, 1985. |
women | TDLo | intravenous | 40ug/kg (0.04mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS | Medical Journal of Australia. Vol. 143, Pg. 305, 1985. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 220 | deg C | EXP | |
pKa Dissociation Constant | 5 | (none) | EXP | |
log P (octanol-water) | 2.82 | (none) | EXP | |
Atmospheric OH Rate Constant | 6.73E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.