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Substance Name: Diethylene glycol
RN: 111-46-6
UNII: 61BR964293
InChIKey: MTHSVFCYNBDYFN-UHFFFAOYSA-N

Classification Codes

  • Antiviral (COVID-19)
  • Human Data
  • Reproductive Effect
  • Skin / Eye Irritant
  • Tumor Data

Molecular Formula

  • C4-H10-O3

Molecular Weight

  • 106.12
 
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Names and Synonyms

Name of Substance

  • 2,2'-Oxybisethanol
  • Diethylene glycol
  • Diglycol
  • Ethanol, 2,2'-oxybis-

Synonyms

  • 1,5-Dihydroxy-3-oxapentane
  • 2,2'-0xydiethanol
  • 2,2'-Dihydroxydiethyl ether
  • 2,2'-Dihydroxyethyl ether
  • 2,2'-Oxybisethanol
  • 2,2'-Oxydiethanol
  • 2,2'-Oxyethanol
  • 2-(2-Hydroxyethoxy)ethanol
  • 3-Oxapentamethylene-1,5-diol
  • 3-Oxapentane-1,5-diol
  • 4-01-00-02390 (Beilstein Handbook Reference)
  • AI3-08416
  • beta,beta'-Dihydroxydiethyl ether
  • Bis(2-hydroxyethyl) ether
  • Bis(beta-hydroxyethyl) ether
  • Brecolane ndg
  • BRN 0969209
  • Caswell No. 338A
  • CCRIS 2193
  • Deactivator E
  • DEG
  • Dicol
  • Diethylene glycol
  • Diethylenglykol
  • Diethylenglykol [Czech]
  • Digenos
  • Diglycol
  • Digol
  • Dihydroxydiethyl ether
  • Dissolvant APV
  • EC 203-872-2
  • EINECS 203-872-2
  • EPA Pesticide Chemical Code 338200
  • Ethanol, 2,2'-oxybis-
  • Ethanol, 2,2'-oxydi-
  • Ethylene diglycol
  • Glycol ether
  • Glycol ethyl ether
  • HSDB 69
  • NSC 36391
  • TL4N
  • UNII-61BR964293

Systematic Names

  • 2,2'-Oxybisethanol
  • 2,2'-Oxydiethanol
  • Diethylene glycol
  • Ethanol, 2,2'-oxybis-

Superlist Names

  • Diethylene glycol
  • Ethanol, 2,2'-oxybis-

Registry Numbers

CAS Registry Number

  • 111-46-6

FDA UNII

  • 61BR964293

Other Registry Numbers

  • 2126734-27-6
  • 4669-26-5

System Generated Number

  • 0000111466

Structure Descriptors

InChI

InChI=1S/C4H10O3/c5-1-3-7-4-2-6/h5-6H,1-4H2

InChIKey

MTHSVFCYNBDYFN-UHFFFAOYSA-N

Smiles

OCCOCCO

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 oral 3300mg/kg (3300mg/kg)   Journal of Industrial Hygiene and Toxicology. Vol. 21, Pg. 173, 1939.
child TDLo oral 2400mg/kg (2400mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LIVER: OTHER CHANGES		 Journal of Pediatrics. Vol. 109, Pg. 731, 1986.
dog LD50 oral 9gm/kg (9000mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 67, Pg. 101, 1939.
guinea pig LD50 oral 7800mg/kg (7800mg/kg) LIVER: OTHER CHANGES

BEHAVIORAL: GENERAL ANESTHETIC

BEHAVIORAL: MUSCLE WEAKNESS		 Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 4, Pg. 142, 1945.
guinea pig LD50 unreported 14gm/kg (14000mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: EXCITEMENT		 Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(3), Pg. 16, 1968.
human LDLo oral 1gm/kg (1000mg/kg)   Journal of Industrial Hygiene and Toxicology. Vol. 21, Pg. 173, 1939.
mouse LCLo inhalation 130mg/m3/2H (130mg/m3) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: GENERAL ANESTHETIC		 Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 10(12), Pg. 30, 1966.
mouse LD50 intraperitoneal 9719mg/kg (9719mg/kg) BLOOD: CHANGES IN SPLEEN

KIDNEY, URETER, AND BLADDER: CHANGES IN BOTH TUBULES AND GLOMERULI

LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA		 Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 6, Pg. 342, 1947.
mouse LD50 oral 23700mg/kg (23700mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: GENERAL ANESTHETIC

LIVER: OTHER CHANGES		 Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 4, Pg. 142, 1945.
mouse LD50 unreported 13300mg/kg (13300mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: EXCITEMENT

GASTROINTESTINAL: NAUSEA OR VOMITING		 Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(3), Pg. 16, 1968.
mouse LDLo subcutaneous 5gm/kg (5000mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 42, Pg. 355, 1931.
rabbit LD50 oral 4400mg/kg (4400mg/kg)   Journal of Industrial Hygiene and Toxicology. Vol. 21, Pg. 173, 1939.
rabbit LD50 oral 4400mg/kg (4400mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: COMA		 Journal of Industrial Hygiene and Toxicology. Vol. 21, Pg. 173, 1939.
rabbit LD50 skin 11890mg/kg (11890mg/kg)   Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 25, 1974.
rabbit LD50 unreported 2688mg/kg (2688mg/kg) BEHAVIORAL: EXCITEMENT

GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(3), Pg. 16, 1968.
rabbit LDLo intramuscular 4472mg/kg (4472mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 59, Pg. 93, 1937.
rabbit LDLo intravenous 2236mg/kg (2236mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 59, Pg. 93, 1937.
rat LD50 intraperitoneal 7700mg/kg (7700mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3836, 1982.
rat LD50 intravenous 6565mg/kg (6565mg/kg)   Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 25, 1974.
rat LD50 oral 12565mg/kg (12565mg/kg)   Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 25, 1974.
rat LD50 subcutaneous 18800mg/kg (18800mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3836, 1982.
rat LD50 unreported 15650mg/kg (15650mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: NAUSEA OR VOMITING		 Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(3), Pg. 16, 1968.
rat LDLo intramuscular 7826mg/kg (7826mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 59, Pg. 93, 1937.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -1.04E+01 deg C   EXP
Boiling Point 245.8 deg C   EXP
log P (octanol-water) -1.470 (none)   EST
Water Solubility 1.00E+06 mg/L 25 EXP
Vapor Pressure 0.0057 mm Hg 25 EXP
Henry's Law Constant 2.00E-09 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 3.00E-11 cm3/molecule-sec 25 EXP

Physical property data is provided to ChemIDplus by SRC, Inc.