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Substance Name: Ornidazole [USAN:INN]
RN: 16773-42-5
UNII: 62XCK0G93T
InChIKey: IPWKIXLWTCNBKN-UHFFFAOYSA-N
Note
- A nitroimidazole antiprotozoal agent used in ameba and trichomonas infections. It is partially plasma-bound and also has radiation-sensitizing action.
Molecular Formula
- C7-H10-Cl-N3-O3
Molecular Weight
- 219.627
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- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Amebicides
- Anti-Infective
- Anti-Infective Agents
- Antiparasitic Agents
- Antiprotozoal Agents
- Antitrichomonal Agents
- Drug / Therapeutic Agent
- Mutation Data
- Radiation-Sensitizing Agents
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Ornidazole
- Ornidazole [USAN:INN]
MeSH Heading
- Ornidazole
Synonyms
- 1-(2-Hydroxy-3-chloropropyl)-2-methyl-5-nitroimidazole
- 1-(3-Chloro-2-hydroxypropyl)-2-methyl-5-nitroimidazole
- 5-23-05-00072 (Beilstein Handbook Reference)
- alpha-(Chlormethyl)-2-methyl-5-nitro-imidazol-1-aethanol
- alpha-(Chlormethyl)-2-methyl-5-nitro-imidazol-1-aethanol [German]
- alpha-(Chloromethyl)-2-methyl-5-nitroimidazole-1-ethanol
- BRN 0614299
- CCRIS 9030
- EINECS 240-826-0
- Madelen
- NSC 95075
- Ornidazol
- Ornidazol [INN-Spanish]
- Ornidazole
- Ornidazolum
- Ornidazolum [INN-Latin]
- Ro 7-0207
- Tiberal
- UNII-62XCK0G93T
Systematic Names
- 1H-Imidazole-1-ethanol, alpha-(chloromethyl)-2-methyl-5-nitro-
- alpha-(Chloromethyl)-2-methyl-5-nitro-1H-imidazole-1-ethanol (9CI)
- Imidazole-1-ethanol, alpha-(chloromethyl)-2-methyl-5-nitro-
- Ornidazole
Registry Numbers
CAS Registry Number
- 16773-42-5
FDA UNII
- 62XCK0G93T
System Generated Number
- 0016773425
Structure Descriptors
InChI
1S/C7H10ClN3O3/c1-5-9-3-7(11(13)14)10(5)4-6(12)2-8/h3,6,12H,2,4H2,1H3InChIKey
IPWKIXLWTCNBKN-UHFFFAOYSA-NSmiles
Cc1ncc(n1CC(CCl)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 1120mg/kg (1120mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 612, 1978. | |
| mouse | LD50 | intravenous | 375mg/kg (375mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 612, 1978. | |
| mouse | LD50 | oral | 1139mg/kg (1139mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 612, 1978. | |
| rabbit | LD50 | oral | > 2gm/kg (2000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 612, 1978. | |
| rat | LD50 | oral | 1780mg/kg (1780mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 612, 1978. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 77-78 | deg C | EXP | |
| log P (octanol-water) | 0.6 | (none) | EXP | |
| Water Solubility | 4330 | mg/L | 25 | EST |
| Vapor Pressure | 2.17E-08 | mm Hg | 25 | EST |
| Henry's Law Constant | 7.92E-12 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 8.72E-12 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.