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Substance Name: Oxyfedrine L-form hydrochloride
RN: 16777-42-7
UNII: 63CF9XK7DA
InChIKey: JMUPNNYLJGSMPK-JPJJPTBZSA-N
Note
- A drug used in the treatment of angina pectoris, heart failure, conduction defects, and myocardial infarction. It is a partial agonist at beta adrenergic receptors and acts as a coronary vasodilator and cardiotonic agent.
Molecular Formula
- C19-H23-N-O3.Cl-H
Molecular Weight
- 349.8556
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Code
- Drug / Therapeutic Agent
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Names and Synonyms
Name of Substance
- Oxyfedrine L-form hydrochloride
Synonyms
- 1-Propanone, 3-((2-hydroxy-1-methyl-2-phenylethyl)amino)-1-(3-methoxyphenyl)-, HCl, l-
- D 563
- D563
- EINECS 240-828-1
- FDA 1576
- Ildamen
- L-(1-Hydroxy-1-phenyl-2-propylamino)-1-(m-methoxyphenyl)-1-propanone hydrochloride
- l-3-(beta-Hydroxy-alpha-methyl-phenethylamino)-3'-methoxypropiophenone, hydrochloride
- L-3-Methoxy-omega-(1-hydroxy-1-phenylisopropylamino)propiophenone hydrochloride
- L-Oxyfedrine hydrochloride
- Modacor
- Oxyfedrin
- Oxyfedrine hydrochloride
- Oxyfedrine L-form HCl
- UNII-63CF9XK7DA
Systematic Names
- (R-(R*,S*))-3-((2-Hydroxy-1-methyl-2-phenylethyl)amino)-3'-methoxypropiophenone hydrochloride
- Propiophenone, 3-((beta-hydroxy-alpha-methylphenethyl)amino)-3'-methoxy-, hydrochloride, (-)-
Registry Numbers
CAS Registry Number
- 16777-42-7
FDA UNII
- 63CF9XK7DA
Other Registry Numbers
- 10084-20-5
- 21071-44-3
- 7413-39-0
System Generated Number
- 0016777427
Molecular Formulas
Molecular Formula
- C19-H23-N-O3.Cl-H
Molecular Formula Fragments
- C19-H23-N-O3
- Cl-H
- COMPONENT
Structure Descriptors
InChI
1S/C19H23NO3.ClH/c1-14(19(22)15-7-4-3-5-8-15)20-12-11-18(21)16-9-6-10-17(13-16)23-2;/h3-10,13-14,19-20,22H,11-12H2,1-2H3;1H/t14-,19-;/m0./s1InChIKey
JMUPNNYLJGSMPK-JPJJPTBZSA-NSmiles
C[C@@H]([C@@H](c1ccccc1)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LD50 | intravenous | 21200ug/kg (21.2mg/kg) | BEHAVIORAL: EXCITEMENT BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 1478, 1967. |
dog | LD50 | intravenous | 50mg/kg (50mg/kg) | BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 1478, 1967. |
dog | LD50 | oral | 200mg/kg (200mg/kg) | BEHAVIORAL: TREMOR CARDIAC: PULSE RATE BEHAVIORAL: ATAXIA | Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 1478, 1967. |
guinea pig | LD50 | intraperitoneal | 83mg/kg (83mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 1478, 1967. |
guinea pig | LD50 | oral | 340mg/kg (340mg/kg) | BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 1478, 1967. |
mouse | LD50 | intraperitoneal | 95mg/kg (95mg/kg) | BEHAVIORAL: EXCITEMENT BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 1478, 1967. |
mouse | LD50 | intravenous | 23mg/kg (23mg/kg) | Yakkyoku. Pharmacy. Vol. 27, Pg. 1401, 1976. | |
mouse | LD50 | oral | 510mg/kg (510mg/kg) | BEHAVIORAL: EXCITEMENT BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 1478, 1967. |
mouse | LD50 | subcutaneous | 123mg/kg (123mg/kg) | Drugs in Japan Vol. 6, Pg. 152, 1982. | |
rat | LD50 | intraperitoneal | 92mg/kg (92mg/kg) | BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 1478, 1967. |
rat | LD50 | intravenous | 46mg/kg (46mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: EXCITEMENT | Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 1478, 1967. |
rat | LD50 | oral | 500mg/kg (500mg/kg) | BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 1478, 1967. |
rat | LD50 | subcutaneous | 99mg/kg (99mg/kg) | Drugs in Japan Vol. 6, Pg. 152, 1982. |