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Substance Name: Oxyfedrine L-form hydrochloride
RN: 16777-42-7
UNII: 63CF9XK7DA
InChIKey: JMUPNNYLJGSMPK-JPJJPTBZSA-N

Note

  • A drug used in the treatment of angina pectoris, heart failure, conduction defects, and myocardial infarction. It is a partial agonist at beta adrenergic receptors and acts as a coronary vasodilator and cardiotonic agent.

Molecular Formula

  • C19-H23-N-O3.Cl-H

Molecular Weight

  • 349.8556
 

Classification Code

  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Oxyfedrine L-form hydrochloride

Synonyms

  • 1-Propanone, 3-((2-hydroxy-1-methyl-2-phenylethyl)amino)-1-(3-methoxyphenyl)-, HCl, l-
  • D 563
  • D563
  • EINECS 240-828-1
  • FDA 1576
  • Ildamen
  • L-(1-Hydroxy-1-phenyl-2-propylamino)-1-(m-methoxyphenyl)-1-propanone hydrochloride
  • l-3-(beta-Hydroxy-alpha-methyl-phenethylamino)-3'-methoxypropiophenone, hydrochloride
  • L-3-Methoxy-omega-(1-hydroxy-1-phenylisopropylamino)propiophenone hydrochloride
  • L-Oxyfedrine hydrochloride
  • Modacor
  • Oxyfedrin
  • Oxyfedrine hydrochloride
  • Oxyfedrine L-form HCl
  • UNII-63CF9XK7DA

Systematic Names

  • (R-(R*,S*))-3-((2-Hydroxy-1-methyl-2-phenylethyl)amino)-3'-methoxypropiophenone hydrochloride
  • Propiophenone, 3-((beta-hydroxy-alpha-methylphenethyl)amino)-3'-methoxy-, hydrochloride, (-)-

Registry Numbers

CAS Registry Number

  • 16777-42-7

FDA UNII

  • 63CF9XK7DA

Other Registry Numbers

  • 10084-20-5
  • 21071-44-3
  • 7413-39-0

System Generated Number

  • 0016777427

Molecular Formulas

Molecular Formula

  • C19-H23-N-O3.Cl-H

Molecular Formula Fragments

  • C19-H23-N-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C19H23NO3.ClH/c1-14(19(22)15-7-4-3-5-8-15)20-12-11-18(21)16-9-6-10-17(13-16)23-2;/h3-10,13-14,19-20,22H,11-12H2,1-2H3;1H/t14-,19-;/m0./s1

InChIKey

JMUPNNYLJGSMPK-JPJJPTBZSA-N

Smiles

C[C@@H]([C@@H](c1ccccc1)O)NCCC(=O)c2cccc(c2)OC.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 intravenous 21200ug/kg (21.2mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 1478, 1967.
dog LD50 intravenous 50mg/kg (50mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 1478, 1967.
dog LD50 oral 200mg/kg (200mg/kg) BEHAVIORAL: TREMOR

CARDIAC: PULSE RATE

BEHAVIORAL: ATAXIA		 Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 1478, 1967.
guinea pig LD50 intraperitoneal 83mg/kg (83mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 1478, 1967.
guinea pig LD50 oral 340mg/kg (340mg/kg) BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 1478, 1967.
mouse LD50 intraperitoneal 95mg/kg (95mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 1478, 1967.
mouse LD50 intravenous 23mg/kg (23mg/kg)   Yakkyoku. Pharmacy. Vol. 27, Pg. 1401, 1976.
mouse LD50 oral 510mg/kg (510mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 1478, 1967.
mouse LD50 subcutaneous 123mg/kg (123mg/kg)   Drugs in Japan Vol. 6, Pg. 152, 1982.
rat LD50 intraperitoneal 92mg/kg (92mg/kg) BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 1478, 1967.
rat LD50 intravenous 46mg/kg (46mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: EXCITEMENT		 Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 1478, 1967.
rat LD50 oral 500mg/kg (500mg/kg) BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 1478, 1967.
rat LD50 subcutaneous 99mg/kg (99mg/kg)   Drugs in Japan Vol. 6, Pg. 152, 1982.