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Substance Name: Dimetindene [INN:BAN]
RN: 5636-83-9
UNII: 661FH77Z3P
InChIKey: MVMQESMQSYOVGV-UHFFFAOYSA-N
Note
- A histamine H1 antagonist. It is used in hypersensitivity reactions, in rhinitis, for pruritus, and in some common cold remedies.
Molecular Formula
- C20-H24-N2
Molecular Weight
- 292.4236
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Anti-Allergic Agents
- Antipruritics
- Dermatologic Agents
- Drug / Therapeutic Agent
- Histamine Agents
- Histamine Antagonists
- Histamine H1 Antagonists
- Neurotransmitter Agents
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Links to Resources
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Names and Synonyms
Name of Substance
- Dimethindene
- Dimetindene [INN:BAN]
MeSH Heading
- Dimethindene
Synonyms
- 2-(1-(2-(2-Dimethylaminoethyl)inden-3-yl)ethyl)pyridine
- 5-22-11-00123 (Beilstein Handbook Reference)
- BRN 0489974
- Dimethindene
- Dimethpyrindene
- Dimetindene
- Dimetindeno
- Dimetindeno [INN-Spanish]
- Dimetindenum
- Dimetindenum [INN-Latin]
- EINECS 227-083-8
- Forhistal
- N,N-Dimethyl-3-(1-(2-pyridyl)ethyl)inden-2-ethylamin
- N,N-Dimethyl-N-(3-(1-(2-pyridyl)ethyl)-2-indenylethyl)amin
- UNII-661FH77Z3P
- Z 2001
Systematic Names
- 1H-Indene-2-ethanamine, N,N-dimethyl-3-(1-(2-pyridinyl)ethyl)-
- Dimetindene
- Pyridine, 2-(1-(2-(2-(dimethylamino)ethyl)inden-3-yl)ethyl)-
Registry Numbers
CAS Registry Number
- 5636-83-9
FDA UNII
- 661FH77Z3P
Related Registry Number
- 3614-69-5 (maleate)
System Generated Number
- 0005636839
Structure Descriptors
InChI
InChI=1S/C20H24N2/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20/h4-10,12,15H,11,13-14H2,1-3H3InChIKey
MVMQESMQSYOVGV-UHFFFAOYSA-NSmiles
CC(C1=C(CCN(C)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | intravenous | 45mg/kg (45mg/kg) | "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 95, 1973. | |
guinea pig | LD50 | oral | 888mg/kg (888mg/kg) | "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 95, 1973. | |
rat | LD50 | intravenous | 27mg/kg (27mg/kg) | "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 95, 1973. | |
rat | LD50 | oral | 618mg/kg (618mg/kg) | "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 95, 1973. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
log P (octanol-water) | 4.980 | (none) | EST | |
Water Solubility | 239 | mg/L | 37 | EXP |
Atmospheric OH Rate Constant | 1.99E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.