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Substance Name: Dimetindene [INN:BAN]
RN: 5636-83-9
UNII: 661FH77Z3P
InChIKey: MVMQESMQSYOVGV-UHFFFAOYSA-N

Note

  • A histamine H1 antagonist. It is used in hypersensitivity reactions, in rhinitis, for pruritus, and in some common cold remedies.

Molecular Formula

  • C20-H24-N2

Molecular Weight

  • 292.4236
 

Classification Codes

  • Anti-Allergic Agents
  • Antipruritics
  • Dermatologic Agents
  • Drug / Therapeutic Agent
  • Histamine Agents
  • Histamine Antagonists
  • Histamine H1 Antagonists
  • Neurotransmitter Agents
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Names and Synonyms

Name of Substance

  • Dimethindene
  • Dimetindene [INN:BAN]

MeSH Heading

  • Dimethindene

Synonyms

  • 2-(1-(2-(2-Dimethylaminoethyl)inden-3-yl)ethyl)pyridine
  • 5-22-11-00123 (Beilstein Handbook Reference)
  • BRN 0489974
  • Dimethindene
  • Dimethpyrindene
  • Dimetindene
  • Dimetindeno
  • Dimetindeno [INN-Spanish]
  • Dimetindenum
  • Dimetindenum [INN-Latin]
  • EINECS 227-083-8
  • Forhistal
  • N,N-Dimethyl-3-(1-(2-pyridyl)ethyl)inden-2-ethylamin
  • N,N-Dimethyl-N-(3-(1-(2-pyridyl)ethyl)-2-indenylethyl)amin
  • UNII-661FH77Z3P
  • Z 2001

Systematic Names

  • 1H-Indene-2-ethanamine, N,N-dimethyl-3-(1-(2-pyridinyl)ethyl)-
  • Dimetindene
  • Pyridine, 2-(1-(2-(2-(dimethylamino)ethyl)inden-3-yl)ethyl)-

Registry Numbers

CAS Registry Number

  • 5636-83-9

FDA UNII

  • 661FH77Z3P

Related Registry Number

  • 3614-69-5 (maleate)

System Generated Number

  • 0005636839

Structure Descriptors

InChI

InChI=1S/C20H24N2/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20/h4-10,12,15H,11,13-14H2,1-3H3

InChIKey

MVMQESMQSYOVGV-UHFFFAOYSA-N

Smiles

CC(C1=C(CCN(C)C)Cc2ccccc12)c3ccccn3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 45mg/kg (45mg/kg)   "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 95, 1973.
guinea pig LD50 oral 888mg/kg (888mg/kg)   "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 95, 1973.
rat LD50 intravenous 27mg/kg (27mg/kg)   "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 95, 1973.
rat LD50 oral 618mg/kg (618mg/kg)   "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 95, 1973.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 4.980 (none)   EST
Water Solubility 239 mg/L 37 EXP
Atmospheric OH Rate Constant 1.99E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.