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Substance Name: Oxazepam [USAN:USP:INN:BAN:JAN]
RN: 604-75-1
UNII: 6GOW6DWN2A
InChIKey: ADIMAYPTOBDMTL-UHFFFAOYSA-N

Note

  • A benzodiazepine used in the treatment of anxiety, alcohol withdrawal, and insomnia.

Molecular Formula

  • C15-H11-Cl-N2-O2

Molecular Weight

  • 286.717
 

Classification Codes

Classification Codes

  • Anti-Anxiety Agents
  • Anxiolytic
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • GABA Agents
  • GABA Modulators
  • Human Data
  • Hypnotics and Sedatives
  • Minor Tranquilizer
  • Mutation Data
  • Neurotransmitter Agents
  • Psychotropic Drugs
  • Reproductive Effect
  • Tranquilizer (Minor)
  • Tranquilizing Agents
  • Tumor Data

Superlist Classification Codes

  • DEA Schedule IV
  • Overall Carcinogenic Evaluation: Group 2B

Names and Synonyms

Name of Substance

  • Oxazepam
  • Oxazepam [USAN:USP:INN:BAN:JAN]

MeSH Heading

  • Oxazepam

Synonyms

  • (+-)-7-Chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one
  • (+-)-Oxazepam
  • (RS)-Oxazepam
  • 1,3-Dihydro-7-chloro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one
  • 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-, (+-)-
  • 7-Chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one
  • 7-Chloro-3-hydroxy-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
  • Abboxapam
  • Adumbran
  • Alepam
  • Ansioxacepam
  • Anxiolit
  • Anxiolit retard
  • Aplakil
  • Astress
  • Azutranquil
  • Bonare
  • CB 8092
  • CCRIS 488
  • Drimuel
  • Droxacepam
  • Durazepam
  • EINECS 210-076-9
  • Enidrel
  • Enidrel (VAN)
  • Hi-Long
  • HSDB 3140
  • Isodin
  • Limbial
  • Murelax
  • N-Desmethyltemazepam
  • Nesontil
  • Noctazepam
  • Nortemazepam
  • Nozepam
  • NSC 169448
  • Ossazepam
  • Ossazepam [DCIT]
  • Oxazepam
  • Oxazepamum
  • Oxazepamum [INN-Latin]
  • Pacienx
  • Praxiten
  • Propax
  • Psicopax
  • Psiquiwas
  • Quilibrex
  • Ro 5-6789
  • Rondar
  • Sedigoa
  • Serax
  • Serenal
  • Serenid
  • Serepax
  • Seresta
  • Serpax
  • Sigacalm
  • Sobril
  • Tarchomin
  • Tazepam
  • Tranquo-buscopan-wirkstoff
  • UNII-6GOW6DWN2A
  • Uskan
  • Vaben
  • Wy 3498
  • WY-3498
  • Z 10 tr
  • Z10-TR
  • Zaxopam

Systematic Names

  • 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-
  • Oxazepam

Superlist Names

  • DEA No. 2835
  • Oxazepam

Registry Numbers

CAS Registry Number

  • 604-75-1

FDA UNII

  • 6GOW6DWN2A

Other Registry Numbers

  • 35295-88-6
  • 61036-43-9

System Generated Number

  • 0000604751

Structure Descriptors

InChI

1S/C15H11ClN2O2/c16-10-6-7-12-11(8-10)13(9-4-2-1-3-5-9)18-15(20)14(19)17-12/h1-8,15,20H,(H,17,19)

InChIKey

ADIMAYPTOBDMTL-UHFFFAOYSA-N

Smiles

c12C(c3ccccc3)=N[C@@H](O)C(Nc1ccc(c2)Cl)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 8mg/kg (8mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CHANGE IN REM SLEEP (HUMAN)

BEHAVIORAL: ATAXIA		 JAMA, Journal of the American Medical Association. Vol. 196, Pg. 662, 1966.
mouse LD50 intraperitoneal 767mg/kg (767mg/kg) BEHAVIORAL: ANTICONVULSANT Journal of Medicinal Chemistry. Vol. 11, Pg. 777, 1968.
mouse LD50 oral 1540mg/kg (1540mg/kg) BEHAVIORAL: ANTICONVULSANT European Journal of Pharmacology. Vol. 4, Pg. 467, 1968.
mouse LD50 subcutaneous > 400mg/kg (400mg/kg)   Current Therapeutic Research, Clinical & Experimental. Vol. 7, Pg. 590, 1965.
rabbit LD50 oral > 2gm/kg (2000mg/kg)   Current Therapeutic Research, Clinical & Experimental. Vol. 7, Pg. 590, 1965.
rat LD50 intraperitoneal 1535mg/kg (1535mg/kg)   Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 10, Pg. 345, 1973.
rat LD50 oral > 8gm/kg (8000mg/kg)   Current Therapeutic Research, Clinical & Experimental. Vol. 7, Pg. 590, 1965.
rat LD50 subcutaneous > 8gm/kg (8000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 10, Pg. 183, 1968.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 205-206 deg C   EXP
log P (octanol-water) 2.24 (none)   EXP
Water Solubility 179 mg/L 25 EST
Vapor Pressure 3.76E-12 mm Hg 25 EST
Henry's Law Constant 5.53E-10 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.39E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.