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Substance Name: Oxazepam [USAN:USP:INN:BAN:JAN]
RN: 604-75-1
UNII: 6GOW6DWN2A
InChIKey: ADIMAYPTOBDMTL-UHFFFAOYSA-N
Note
- A benzodiazepine used in the treatment of anxiety, alcohol withdrawal, and insomnia.
Molecular Formula
- C15-H11-Cl-N2-O2
Molecular Weight
- 286.717
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Anti-Anxiety Agents
- Anxiolytic
- Central Nervous System Agents
- Central Nervous System Depressants
- Drug / Therapeutic Agent
- GABA Agents
- GABA Modulators
- Human Data
- Hypnotics and Sedatives
- Minor Tranquilizer
- Mutation Data
- Neurotransmitter Agents
- Psychotropic Drugs
- Reproductive Effect
- Tranquilizer (Minor)
- Tranquilizing Agents
- Tumor Data
Superlist Classification Codes
- DEA Schedule IV
- Overall Carcinogenic Evaluation: Group 2B
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Names and Synonyms
Name of Substance
- Oxazepam
- Oxazepam [USAN:USP:INN:BAN:JAN]
MeSH Heading
- Oxazepam
Synonyms
- (+-)-7-Chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one
- (+-)-Oxazepam
- (RS)-Oxazepam
- 1,3-Dihydro-7-chloro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one
- 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-, (+-)-
- 7-Chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one
- 7-Chloro-3-hydroxy-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
- Abboxapam
- Adumbran
- Alepam
- Ansioxacepam
- Anxiolit
- Anxiolit retard
- Aplakil
- Astress
- Azutranquil
- Bonare
- CB 8092
- CCRIS 488
- Drimuel
- Droxacepam
- Durazepam
- EINECS 210-076-9
- Enidrel
- Enidrel (VAN)
- Hi-Long
- HSDB 3140
- Isodin
- Limbial
- Murelax
- N-Desmethyltemazepam
- Nesontil
- Noctazepam
- Nortemazepam
- Nozepam
- NSC 169448
- Ossazepam
- Ossazepam [DCIT]
- Oxazepam
- Oxazepamum
- Oxazepamum [INN-Latin]
- Pacienx
- Praxiten
- Propax
- Psicopax
- Psiquiwas
- Quilibrex
- Ro 5-6789
- Rondar
- Sedigoa
- Serax
- Serenal
- Serenid
- Serepax
- Seresta
- Serpax
- Sigacalm
- Sobril
- Tarchomin
- Tazepam
- Tranquo-buscopan-wirkstoff
- UNII-6GOW6DWN2A
- Uskan
- Vaben
- Wy 3498
- WY-3498
- Z 10 tr
- Z10-TR
- Zaxopam
Systematic Names
- 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-
- Oxazepam
Superlist Names
- DEA No. 2835
- Oxazepam
Registry Numbers
CAS Registry Number
- 604-75-1
FDA UNII
- 6GOW6DWN2A
Other Registry Numbers
- 35295-88-6
- 61036-43-9
System Generated Number
- 0000604751
Structure Descriptors
InChI
InChI=1S/C15H11ClN2O2/c16-10-6-7-12-11(8-10)13(9-4-2-1-3-5-9)18-15(20)14(19)17-12/h1-8,15,20H,(H,17,19)InChIKey
ADIMAYPTOBDMTL-UHFFFAOYSA-NSmiles
OC1N=C(c2ccccc2)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
child | TDLo | oral | 8mg/kg (8mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CHANGE IN REM SLEEP (HUMAN) BEHAVIORAL: ATAXIA | JAMA, Journal of the American Medical Association. Vol. 196, Pg. 662, 1966. |
mouse | LD50 | intraperitoneal | 767mg/kg (767mg/kg) | BEHAVIORAL: ANTICONVULSANT | Journal of Medicinal Chemistry. Vol. 11, Pg. 777, 1968. |
mouse | LD50 | oral | 1540mg/kg (1540mg/kg) | BEHAVIORAL: ANTICONVULSANT | European Journal of Pharmacology. Vol. 4, Pg. 467, 1968. |
mouse | LD50 | subcutaneous | > 400mg/kg (400mg/kg) | Current Therapeutic Research, Clinical & Experimental. Vol. 7, Pg. 590, 1965. | |
rabbit | LD50 | oral | > 2gm/kg (2000mg/kg) | Current Therapeutic Research, Clinical & Experimental. Vol. 7, Pg. 590, 1965. | |
rat | LD50 | intraperitoneal | 1535mg/kg (1535mg/kg) | Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 10, Pg. 345, 1973. | |
rat | LD50 | oral | > 8gm/kg (8000mg/kg) | Current Therapeutic Research, Clinical & Experimental. Vol. 7, Pg. 590, 1965. | |
rat | LD50 | subcutaneous | > 8gm/kg (8000mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 10, Pg. 183, 1968. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 205-206 | deg C | EXP | |
log P (octanol-water) | 2.24 | (none) | EXP | |
Water Solubility | 179 | mg/L | 25 | EST |
Vapor Pressure | 3.76E-12 | mm Hg | 25 | EST |
Henry's Law Constant | 5.53E-10 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 1.39E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.