Substance Name: Thrombin
RN: 9002-04-4
UNII: 6K15ABL77G
Notes
- An enzyme formed from PROTHROMBIN that converts FIBRINOGEN to FIBRIN.
- Inhibited by antithrombin III.
Molecular Formula
- Unspecified
Classification Codes
- Coagulants
- Hematologic Agents
- Hemostatics
- Mutation Data
- TSCA Flag XU (Exempt from Reporting under Chemical Data Reporting Rule)
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Names and Synonyms
Name of Substance
- Factor IIa
- Thrombin
- Thrombin human
- Thrombin, topical
Synonyms
- Blood-coagulation factor II, activated
- Blood-coagulation factor IIa
- Bovine thrombin
- E.C. 3.4.21.5
- E.C. 3.4.4.13
- EINECS 232-648-7
- Evithrom
- Factor IIa
- Fibrinogenase
- Thrombase
- Thrombin
- Thrombin II
- Thrombin JMI
- Thrombin, topical (recombinant)
- Thrombin-C
- Thrombinar
- Thrombofort
- Thrombostat
- Tropostasin
- UNII-6K15ABL77G
Systematic Name
- Thrombin
Registry Numbers
CAS Registry Number
- 9002-04-4
FDA UNII
- 6K15ABL77G
Other Registry Numbers
- 105881-84-3
- 53028-63-0
- 8050-02-0
- 8059-56-1
- 9014-41-9
System Generated Number
- 0009002044
Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | > 50mL/kg (50mL/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 329, 1984. |
| mouse | LD50 | intravenous | 7771ug/kg (7.771mg/kg) | KIDNEY, URETER, AND BLADDER: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16, Pg. 669, 1988. |
| mouse | LD50 | skin | > 3gm/kg (3000mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 1, Pg. 272, 1973. |
| mouse | LD50 | subcutaneous | > 50mL/kg (50mL/kg) | Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 329, 1984. | |
| rat | LD50 | intraperitoneal | > 40mL/kg (40mL/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 329, 1984. |
| rat | LD50 | subcutaneous | > 40mL/kg (40mL/kg) | Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 329, 1984. |