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Substance Name: Pipobroman [USAN:USP:INN]
RN: 54-91-1
UNII: 6Q99RDT97R
InChIKey: NJBFOOCLYDNZJN-UHFFFAOYSA-N

Note

  • An antineoplastic agent that acts by alkylation.

Molecular Formula

  • C10-H16-Br2-N2-O2

Molecular Weight

  • 356.056
 

Classification Codes

  • Alkylating Agents
  • Antineoplastic
  • Antineoplastic Agents
  • Antineoplastic Agents, Alkylating
  • Drug / Therapeutic Agent
  • Mutation Data
  • Noxae
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Pipobroman
  • Pipobroman [USAN:USP:INN]

MeSH Heading

  • Pipobroman

Synonyms

  • 1,4-Bis(3-bromopropionyl)piperazine
  • 5-23-01-00046 (Beilstein Handbook Reference)
  • A 1803
  • A-8103
  • AI3-50113
  • Amedel
  • BRN 0749866
  • CCRIS 2753
  • HSDB 3249
  • N,N-Bis-(3-bromopropionyl)-piperazine
  • NSC 25154
  • NSC-25154
  • Piperazine, 1,4-bis(3-bromo-1-oxopropyl)-
  • Piperazine, 1,4-bis(3-bromopropionyl)-
  • Pipobroman
  • Pipobromanum
  • Pipobromanum [INN-Latin]
  • UNII-6Q99RDT97R
  • Vercyte

Systematic Names

  • Piperazine, 1,4-bis(3-bromo-1-oxopropyl)-
  • Piperazine, 1,4-bis(3-bromopropionyl)-
  • Pipobroman

Superlist Name

  • Pipobroman

Registry Numbers

CAS Registry Number

  • 54-91-1

FDA UNII

  • 6Q99RDT97R

System Generated Number

  • 0000054911

Structure Descriptors

InChI

1S/C10H16Br2N2O2/c11-3-1-9(15)13-5-7-14(8-6-13)10(16)2-4-12/h1-8H2

InChIKey

NJBFOOCLYDNZJN-UHFFFAOYSA-N

Smiles

N1(C(CCBr)=O)CCN(C(CCBr)=O)CC1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 285mg/kg (285mg/kg)   Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 37, Pg. 249, 1980.
mouse LD50 oral 382mg/kg (382mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 467, 1973.
mouse LD50 subcutaneous 353mg/kg (353mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 467, 1973.
rat LD50 intraperitoneal 140mg/kg (140mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 467, 1973.
rat LD50 oral 220mg/kg (220mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 467, 1973.
rat LD50 subcutaneous 139mg/kg (139mg/kg)   Drugs in Japan Vol. 6, Pg. 638, 1982.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point > 300 deg C   EXP
log P (octanol-water) 0.42 (none)   EXP
Water Solubility 2490 mg/L 25 EST
Vapor Pressure 1.78E-07 mm Hg 25 EST
Henry's Law Constant 8.57E-13 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 5.15E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.