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Substance Name: Trihexyphenidyl [INN:BAN]
RN: 144-11-6
UNII: 6RC5V8B7PO
InChIKey: HWHLPVGTWGOCJO-UHFFFAOYSA-N

Note

  • One of the centrally acting MUSCARINIC ANTAGONISTS used for treatment of PARKINSONIAN DISORDERS and drug-induced extrapyramidal movement disorders and as an antispasmodic.

Molecular Formula

  • C20-H31-N-O

Molecular Weight

  • 301.471
 

Classification Codes

  • Anti-Dyskinesia Agents
  • Antiparkinson Agents
  • Central Nervous System Agents
  • Cholinergic Agents
  • Cholinergic Antagonists
  • Drug / Therapeutic Agent
  • Muscarinic Antagonists
  • Neurotransmitter Agents
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Names and Synonyms

Results Name

  • Trihexyphenidyl [INN:BAN]

Name of Substance

  • Trihexyphenidyl
  • Trihexyphenidyl [INN:BAN]

MeSH Heading

  • Trihexyphenidyl

Synonyms

  • 1-Piperidinepropanol, alpha-cyclohexyl-alpha-phenyl-
  • 5-20-02-00231 (Beilstein Handbook Reference)
  • Benzhexol
  • Benzhexolum
  • BRN 0088959
  • EINECS 205-614-4
  • HSDB 3196
  • NSC 12268
  • Parkinane retard
  • Sedrena (free base)
  • Trihexifenidilo
  • Trihexifenidilo [INN-Spanish]
  • Trihexyphenidyl
  • Trihexyphenidyle
  • Trihexyphenidyle [INN-French]
  • Trihexyphenidylum
  • Trihexyphenidylum [INN-Latin]
  • Triphenidyl
  • UNII-6RC5V8B7PO

Systematic Names

  • 1-Piperidinepropanol, alpha-cyclohexyl-alpha-phenyl-
  • Trihexyphenidyl

Registry Numbers

CAS Registry Number

  • 144-11-6

FDA UNII

  • 6RC5V8B7PO

Related Registry Number

  • 52-49-3 (hydrochloride)

System Generated Number

  • 0000144116

Structure Descriptors

InChI

1S/C20H31NO/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2

InChIKey

HWHLPVGTWGOCJO-UHFFFAOYSA-N

Smiles

c1([C@@](C2CCCCC2)(CCN2CCCCC2)O)ccccc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 150mg/kg (150mg/kg) BEHAVIORAL: IRRITABILITY

BEHAVIORAL: EXCITEMENT

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 1727, 1971.
mouse LD50 intravenous 41mg/kg (41mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 226, Pg. 18, 1955.
mouse LD50 oral 335mg/kg (335mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1778, 1970.
mouse LD50 subcutaneous 153mg/kg (153mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Farmakologiya i Toksikologiya Vol. 23, Pg. 8, 1960.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 4.49 (none)   EXP
Water Solubility 18 mg/L 25 EST
Vapor Pressure 1.21E-08 mm Hg 25 EST
Henry's Law Constant 4.73E-10 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.29E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.