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Substance Name: Trihexyphenidyl [INN:BAN]
RN: 144-11-6
UNII: 6RC5V8B7PO
InChIKey: HWHLPVGTWGOCJO-UHFFFAOYSA-N
Note
- One of the centrally acting MUSCARINIC ANTAGONISTS used for treatment of PARKINSONIAN DISORDERS and drug-induced extrapyramidal movement disorders and as an antispasmodic.
Molecular Formula
- C20-H31-N-O
Molecular Weight
- 301.471
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- Classifications
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- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Anti-Dyskinesia Agents
- Antiparkinson Agents
- Central Nervous System Agents
- Cholinergic Agents
- Cholinergic Antagonists
- Drug / Therapeutic Agent
- Muscarinic Antagonists
- Neurotransmitter Agents
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Names and Synonyms
Results Name
- Trihexyphenidyl [INN:BAN]
Name of Substance
- Trihexyphenidyl
- Trihexyphenidyl [INN:BAN]
MeSH Heading
- Trihexyphenidyl
Synonyms
- 1-Piperidinepropanol, alpha-cyclohexyl-alpha-phenyl-
- 5-20-02-00231 (Beilstein Handbook Reference)
- Benzhexol
- Benzhexolum
- BRN 0088959
- EINECS 205-614-4
- HSDB 3196
- NSC 12268
- Parkinane retard
- Sedrena (free base)
- Trihexifenidilo
- Trihexifenidilo [INN-Spanish]
- Trihexyphenidyl
- Trihexyphenidyle
- Trihexyphenidyle [INN-French]
- Trihexyphenidylum
- Trihexyphenidylum [INN-Latin]
- Triphenidyl
- UNII-6RC5V8B7PO
Systematic Names
- 1-Piperidinepropanol, alpha-cyclohexyl-alpha-phenyl-
- Trihexyphenidyl
Registry Numbers
CAS Registry Number
- 144-11-6
FDA UNII
- 6RC5V8B7PO
Related Registry Number
- 52-49-3 (hydrochloride)
System Generated Number
- 0000144116
Structure Descriptors
InChI
InChI=1S/C20H31NO/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2InChIKey
HWHLPVGTWGOCJO-UHFFFAOYSA-NSmiles
OC(CCN1CCCCC1)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 150mg/kg (150mg/kg) | BEHAVIORAL: IRRITABILITY BEHAVIORAL: EXCITEMENT SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE | Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 1727, 1971. |
| mouse | LD50 | intravenous | 41mg/kg (41mg/kg) | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 226, Pg. 18, 1955. | |
| mouse | LD50 | oral | 335mg/kg (335mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1778, 1970. | |
| mouse | LD50 | subcutaneous | 153mg/kg (153mg/kg) | BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Farmakologiya i Toksikologiya Vol. 23, Pg. 8, 1960. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| log P (octanol-water) | 4.49 | (none) | EXP | |
| Water Solubility | 18 | mg/L | 25 | EST |
| Vapor Pressure | 1.21E-08 | mm Hg | 25 | EST |
| Henry's Law Constant | 4.73E-10 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 1.29E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.