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Substance Name: Almitrine mesylate [USAN]
RN: 29608-49-9
UNII: 6RY6V6XM8T
InChIKey: MRDBGMJEPGXQHJ-UHFFFAOYSA-N
Note
- A respiratory stimulant that enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies. The drug increases arterial oxygen tension while decreasing arterial carbon dioxide tension in patients with chronic obstructive pulmonary disease. It may also prove useful in the treatment of nocturnal oxygen desaturation without impairing the quality of sleep.
Molecular Formula
- C26-H29-F2-N7.2C-H4-O3-S
Molecular Weight
- 669.7713
- All
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- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Codes
- Drug / Therapeutic Agent
- Respiratory Stimulant
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Names and Synonyms
Name of Substance
- Almitrine dimethanesulfonate
- Almitrine mesylate [USAN]
Synonyms
- (Diallylamino-4'-6'-triazinyl-2')-1-(bis p-fluorobenzydryl)-4 piperazine bis methanesulfonate
- 2,4-Bis(allylamino)-6-(4-(bis(p-fluorophenyl)methyl)-1-piperazinyl)-s-triazine dimethanesulfonate
- 6-(4-(Bis(4-fluorophenyl)methyl)-1-piperazinyl)-N,N'-di-2-propenyl-1,3,5-triazine-2,4-diamine dimethanesulfonate
- Almitrine bismesylate
- Almitrine bismethane sulfonate
- Almitrine dimesylate
- Almitrine mesylate
- EINECS 249-726-1
- S 2620 bismethanesulfonate
- S-2620
- UNII-6RY6V6XM8T
- Vectarion
Systematic Names
- 1,3,5-Triazine-2,4-diamine, 6-(4-(bis(4-fluorophenyl)methyl)-1-piperazinyl)-N,N'-di-2-propenyl-, dimethanesulfonate
- N,N'-Diallyl-6-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-1,3,5-triazine-2,4-diamine dimethanesulphonate
Registry Numbers
CAS Registry Number
- 29608-49-9
FDA UNII
- 6RY6V6XM8T
Related Registry Number
- 27469-53-0 (Parent)
System Generated Number
- 0029608499
Molecular Formulas
Molecular Formula
- C26-H29-F2-N7.2C-H4-O3-S
Molecular Formula Fragments
- C-H4-O3-S
- C26-H29-F2-N7
- COMPONENT
Structure Descriptors
InChI
InChI=1S/C26H29F2N7.2CH4O3S/c1-3-13-29-24-31-25(30-14-4-2)33-26(32-24)35-17-15-34(16-18-35)23(19-5-9-21(27)10-6-19)20-7-11-22(28)12-8-20;2*1-5(2,3)4/h3-12,23H,1-2,13-18H2,(H2,29,30,31,32,33);2*1H3,(H,2,3,4)InChIKey
MRDBGMJEPGXQHJ-UHFFFAOYSA-NSmiles
CS(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 370mg/kg (370mg/kg) | Journal de Pharmacologie. Vol. 3, Pg. 363, 1972. | |
mouse | LD50 | intravenous | 207mg/kg (207mg/kg) | Journal de Pharmacologie. Vol. 3, Pg. 363, 1972. | |
mouse | LD50 | oral | > 2gm/kg (2000mg/kg) | Experientia. Vol. 28, Pg. 814, 1972. |