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Substance Name: Almitrine mesylate [USAN]
RN: 29608-49-9
UNII: 6RY6V6XM8T
InChIKey: MRDBGMJEPGXQHJ-UHFFFAOYSA-N

Note

  • A respiratory stimulant that enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies. The drug increases arterial oxygen tension while decreasing arterial carbon dioxide tension in patients with chronic obstructive pulmonary disease. It may also prove useful in the treatment of nocturnal oxygen desaturation without impairing the quality of sleep.

Molecular Formula

  • C26-H29-F2-N7.2C-H4-O3-S

Molecular Weight

  • 669.7713
 

Classification Codes

  • Drug / Therapeutic Agent
  • Respiratory Stimulant
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Names and Synonyms

Name of Substance

  • Almitrine dimethanesulfonate
  • Almitrine mesylate [USAN]

Synonyms

  • (Diallylamino-4'-6'-triazinyl-2')-1-(bis p-fluorobenzydryl)-4 piperazine bis methanesulfonate
  • 2,4-Bis(allylamino)-6-(4-(bis(p-fluorophenyl)methyl)-1-piperazinyl)-s-triazine dimethanesulfonate
  • 6-(4-(Bis(4-fluorophenyl)methyl)-1-piperazinyl)-N,N'-di-2-propenyl-1,3,5-triazine-2,4-diamine dimethanesulfonate
  • Almitrine bismesylate
  • Almitrine bismethane sulfonate
  • Almitrine dimesylate
  • Almitrine mesylate
  • EINECS 249-726-1
  • S 2620 bismethanesulfonate
  • S-2620
  • UNII-6RY6V6XM8T
  • Vectarion

Systematic Names

  • 1,3,5-Triazine-2,4-diamine, 6-(4-(bis(4-fluorophenyl)methyl)-1-piperazinyl)-N,N'-di-2-propenyl-, dimethanesulfonate
  • N,N'-Diallyl-6-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-1,3,5-triazine-2,4-diamine dimethanesulphonate

Registry Numbers

CAS Registry Number

  • 29608-49-9

FDA UNII

  • 6RY6V6XM8T

Related Registry Number

  • 27469-53-0 (Parent)

System Generated Number

  • 0029608499

Molecular Formulas

Molecular Formula

  • C26-H29-F2-N7.2C-H4-O3-S

Molecular Formula Fragments

  • C-H4-O3-S
  • C26-H29-F2-N7
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C26H29F2N7.2CH4O3S/c1-3-13-29-24-31-25(30-14-4-2)33-26(32-24)35-17-15-34(16-18-35)23(19-5-9-21(27)10-6-19)20-7-11-22(28)12-8-20;2*1-5(2,3)4/h3-12,23H,1-2,13-18H2,(H2,29,30,31,32,33);2*1H3,(H,2,3,4)

InChIKey

MRDBGMJEPGXQHJ-UHFFFAOYSA-N

Smiles

CS(=O)(=O)O.CS(=O)(=O)O.Fc1ccc(cc1)C(N2CCN(CC2)c3nc(NCC=C)nc(NCC=C)n3)c4ccc(F)cc4

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 370mg/kg (370mg/kg)   Journal de Pharmacologie. Vol. 3, Pg. 363, 1972.
mouse LD50 intravenous 207mg/kg (207mg/kg)   Journal de Pharmacologie. Vol. 3, Pg. 363, 1972.
mouse LD50 oral > 2gm/kg (2000mg/kg)   Experientia. Vol. 28, Pg. 814, 1972.