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Substance Name: Tranexamic acid [USAN:USP:INN:BAN:JAN]
RN: 1197-18-8
UNII: 6T84R30KC1
InChIKey: GYDJEQRTZSCIOI-LJGSYFOKSA-N
Note
- Antifibrinolytic hemostatic used in severe hemorrhage.
Molecular Formula
- C8-H15-N-O2
Molecular Weight
- 157.212
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- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Antifibrinolytic Agents
- Antiviral (COVID-19)
- Coagulants
- Drug / Therapeutic Agent
- Fibrin Modulating Agents
- Hematologic Agents
- Hemostatic
- Hemostatics
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Tranexamic acid
- Tranexamic acid [USAN:USP:INN:BAN:JAN]
MeSH Heading
- Tranexamic acid
Synonyms
- 3-14-00-00868 (Beilstein Handbook Reference)
- Acide tranexamique
- Acide tranexamique [INN-French]
- Acido tranexamico
- Acido tranexamico [INN-Spanish]
- Acidum tranexamicum
- Acidum tranexamicum [INN-Latin]
- Amikapron
- Amstat
- Anvitoff
- BAY 3517
- BRN 2207452
- Carxamin
- CL 65336
- Cyclocapron
- Cyklokapron
- DV-79
- EINECS 214-818-2
- Emorhalt
- Exacyl
- Frenolyse
- Hexapromin
- Hexatron
- LB1148
- Lysteda
- Mastop
- NSC 291305
- Retavase
- Rikavarin
- Rikavarin-S
- RP 18,429
- Spiramin
- Tamcha
- Tranex
- Tranexamic acid
- Tranexamsaeure
- Tranexan
- Tranhexamic acid
- trans Amcha
- trans-1-Aminomethylcyclohexane-4-carboxylic acid
- trans-4-(Aminomethyl)cyclohexanecarboxylic acid
- trans-4-Aminomethylcyclohexane-1-carboxylic acid
- trans-p-(Aminomethyl)cyclohexanecarboxylic acid
- Transamin
- Transamlon
- Trasamlon
- TXA
- Ugurol
- UNII-6T84R30KC1
Systematic Names
- Cyclohexanecarboxylic acid, 4-(aminomethyl)-, trans-
- Tranexamic acid
Registry Numbers
CAS Registry Number
- 1197-18-8
FDA UNII
- 6T84R30KC1
System Generated Number
- 0001197188
Structure Descriptors
InChI
InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)/t6-,7-InChIKey
GYDJEQRTZSCIOI-LJGSYFOKSA-NSmiles
NC[C@@H]1CC[C@H](CC1)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| chicken | LD50 | oral | > 10gm/kg (10000mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 5, Pg. 389, 1971. | |
| dog | LD50 | intravenous | 1110mg/kg (1110mg/kg) | Drugs in Japan Vol. 6, Pg. 512, 1982. | |
| dog | LD50 | oral | > 5gm/kg (5000mg/kg) | Drugs in Japan Vol. 6, Pg. 512, 1982. | |
| mouse | LD50 | intraperitoneal | 4200mg/kg (4200mg/kg) | "Modern Pharmaceuticals of Japan, V," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1975Vol. -, Pg. 108, 1975. | |
| mouse | LD50 | intravenous | 1350mg/kg (1350mg/kg) | Drugs in Japan Vol. 6, Pg. 512, 1982. | |
| mouse | LD50 | oral | > 10gm/kg (10000mg/kg) | Drugs in Japan Vol. 6, Pg. 512, 1982. | |
| mouse | LD50 | subcutaneous | 5310mg/kg (5310mg/kg) | Drugs in Japan Vol. 6, Pg. 512, 1982. | |
| rat | LD50 | intravenous | 1200mg/kg (1200mg/kg) | Acta Pharmacologica et Toxicologica. Vol. 22, Pg. 340, 1965. | |
| rat | LD50 | subcutaneous | 4620mg/kg (4620mg/kg) | Drugs in Japan Vol. 6, Pg. 512, 1982. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | >300 | deg C | EXP | |
| log P (octanol-water) | -1.900 | (none) | EST | |
| Water Solubility | 1.67E+05 | mg/L | EXP | |
| Atmospheric OH Rate Constant | 4.37E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.