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Substance Name: Spiramycin [USAN:INN:BAN]
RN: 8025-81-8
UNII: 71ODY0V87H
Note
- A macrolide antibiotic produced by Streptomyces ambofaciens. The drug is effective against gram-positive aerobic pathogens, N. gonorrhoeae, and staphylococci. It is used to treat infections caused by bacteria and Toxoplasma gondii.
Molecular Formula
- Unspecified
Molecular Weight
- 842.0497
Classification Codes
- Anti-Bacterial Agents
- Anti-Infective Agents
- Antibacterial
- Antiparasitic Agents
- Antiprotozoal Agents
- Coccidiostats
- Drug / Therapeutic Agent
- Human Data
- Mutation Data
- Natural Product
- Reproductive Effect
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Links to Resources
NLM Resources (File Locators)
Other Resources (Internet Locators)
Names and Synonyms
Name of Substance
- Spiramycin
- Spiramycin [USAN:INN:BAN]
MeSH Heading
- Spiramycin
Synonyms
- 5337 R.P.
- Antibiotic 799
- EINECS 232-429-6
- Espiramicin
- Espiramicina
- Espiramicina [INN-Spanish]
- Foromacidin
- HSDB 7027
- IL 5902
- IL-5902
- NSC-55926
- NSC-64393
- Provamycin
- Rovamycin
- Rovamycine
- RP 5337
- Sequamycin
- Spiramycin
- Spiramycine
- Spiramycine [INN-French]
- Spiramycinum
- Spiramycinum [INN-Latin]
- UNII-71ODY0V87H
Systematic Name
- Spiramycin
Registry Numbers
CAS Registry Number
- 8025-81-8
FDA UNII
- 71ODY0V87H
Other Registry Numbers
- 1394-00-9
- 78355-64-3
System Generated Number
- 0008025818
Structure Descriptors
Smiles
['Rgp']O[C@@H]1CC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | oral | 5200mg/kg (5200mg/kg) | Canadian Medical Association Journal. Vol. 77, Pg. 623, 1957. | |
dog | LD50 | oral | 5200mg/kg (5200mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Canadian Medical Association Journal. Vol. 77, Pg. 623, 1957. |
man | TDLo | oral | 133mg/kg/5D (133mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: OTHER CHANGES | Lancet. Vol. 2, Pg. 993, 1978. |
mouse | LD50 | intraperitoneal | 322mg/kg (322mg/kg) | Japanese Journal of Antibiotics. Vol. 23, Pg. 429, 1970. | |
mouse | LD50 | intravenous | 130mg/kg (130mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 386, 1958. | |
mouse | LD50 | oral | 2900mg/kg (2900mg/kg) | Therapie. Vol. 23, Pg. 161, 1968. | |
mouse | LD50 | subcutaneous | 1470mg/kg (1470mg/kg) | Japanese Journal of Antibiotics. Vol. 23, Pg. 429, 1970. | |
mouse | LDLo | unreported | 100mg/kg (100mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 693, 1967. | |
rabbit | LD50 | intraperitoneal | 1130mg/kg (1130mg/kg) | Japanese Journal of Antibiotics. Vol. 23, Pg. 429, 1970. | |
rabbit | LD50 | intravenous | 182mg/kg (182mg/kg) | Japanese Journal of Antibiotics. Vol. 23, Pg. 429, 1970. | |
rabbit | LD50 | oral | > 4gm/kg (4000mg/kg) | Japanese Journal of Antibiotics. Vol. 23, Pg. 429, 1970. | |
rat | LD50 | intraperitoneal | 575mg/kg (575mg/kg) | Japanese Journal of Antibiotics. Vol. 23, Pg. 429, 1970. | |
rat | LD50 | intravenous | 170mg/kg (170mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 386, 1958. | |
rat | LD50 | oral | 3550mg/kg (3550mg/kg) | Japanese Journal of Antibiotics. Vol. 23, Pg. 429, 1970. | |
rat | LD50 | subcutaneous | 1gm/kg (1000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 386, 1958. |