Skip Navigation
ChemIDplus A TOXNET DATABASE Lite•Browse•Advanced

Substance Name: Spiramycin [USAN:INN:BAN]
RN: 8025-81-8
UNII: 71ODY0V87H

Note

  • A macrolide antibiotic produced by Streptomyces ambofaciens. The drug is effective against gram-positive aerobic pathogens, N. gonorrhoeae, and staphylococci. It is used to treat infections caused by bacteria and Toxoplasma gondii.

Molecular Formula

  • Unspecified

Molecular Weight

  • 842.0497
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antibacterial
  • Antiparasitic Agents
  • Antiprotozoal Agents
  • Coccidiostats
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Natural Product
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Spiramycin
  • Spiramycin [USAN:INN:BAN]

MeSH Heading

  • Spiramycin

Synonyms

  • 5337 R.P.
  • Antibiotic 799
  • EINECS 232-429-6
  • Espiramicin
  • Espiramicina
  • Espiramicina [INN-Spanish]
  • Foromacidin
  • HSDB 7027
  • IL 5902
  • NSC-64393
  • Provamycin
  • Rovamycin
  • RP 5337
  • Sequamycin
  • Spiramycin
  • Spiramycine
  • Spiramycine [INN-French]
  • Spiramycinum
  • Spiramycinum [INN-Latin]
  • UNII-71ODY0V87H

Systematic Name

  • Spiramycin

Registry Numbers

CAS Registry Number

  • 8025-81-8

FDA UNII

  • 71ODY0V87H

Other Registry Numbers

  • 1394-00-9
  • 78355-64-3

System Generated Number

  • 0008025818

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 5200mg/kg (5200mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

GASTROINTESTINAL: NAUSEA OR VOMITING		 Canadian Medical Association Journal. Vol. 77, Pg. 623, 1957.
man TDLo oral 133mg/kg/5D (133mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: OTHER CHANGES		 Lancet. Vol. 2, Pg. 993, 1978.
mouse LD50 intraperitoneal 322mg/kg (322mg/kg)   Japanese Journal of Antibiotics. Vol. 23, Pg. 429, 1970.
mouse LD50 intravenous 130mg/kg (130mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 386, 1958.
mouse LD50 oral 2900mg/kg (2900mg/kg)   Therapie. Vol. 23, Pg. 161, 1968.
mouse LD50 subcutaneous 1470mg/kg (1470mg/kg)   Japanese Journal of Antibiotics. Vol. 23, Pg. 429, 1970.
mouse LDLo unreported 100mg/kg (100mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 693, 1967.
rabbit LD50 intraperitoneal 1130mg/kg (1130mg/kg)   Japanese Journal of Antibiotics. Vol. 23, Pg. 429, 1970.
rabbit LD50 intravenous 182mg/kg (182mg/kg)   Japanese Journal of Antibiotics. Vol. 23, Pg. 429, 1970.
rabbit LD50 oral > 4gm/kg (4000mg/kg)   Japanese Journal of Antibiotics. Vol. 23, Pg. 429, 1970.
rat LD50 intraperitoneal 575mg/kg (575mg/kg)   Japanese Journal of Antibiotics. Vol. 23, Pg. 429, 1970.
rat LD50 intravenous 170mg/kg (170mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 386, 1958.
rat LD50 oral 3550mg/kg (3550mg/kg)   Japanese Journal of Antibiotics. Vol. 23, Pg. 429, 1970.
rat LD50 subcutaneous 1gm/kg (1000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 386, 1958.