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Substance Name: Benziodarone [INN:BAN:DCF:JAN]
RN: 68-90-6
UNII: 75CL65GTYR
InChIKey: CZCHIEJNWPNBDE-UHFFFAOYSA-N

Classification Codes

  • Antirheumatic Agents
  • Drug / Therapeutic Agent
  • Gout Suppressants
  • Renal Agents
  • Uricosuric Agents

Molecular Formula

  • C17-H12-I2-O3

Molecular Weight

  • 518.0788
 
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Names and Synonyms

Name of Substance

  • Benziodarone
  • Benziodarone [INN:BAN:DCF:JAN]

Synonyms

  • 2-Ethyl-3-(3',5'-diiodo-4'-hydroxybenzoyl)-cumarone
  • 3,5-Diiodo-4-hydroxyphenyl 2-ethyl-3-benzofuranyl ketone
  • 5-18-02-00335 (Beilstein Handbook Reference)
  • Aethyl-2-(3',5'-dijod-4'-oxybenzoyl)-3 cumaron
  • Aethyl-2-(3',5'-dijod-4'-oxybenzoyl)-3 cumaron [German]
  • Algocor
  • Amplivix
  • Benziodaron
  • Benziodarona
  • Benziodarona [INN-Spanish]
  • Benziodarone
  • Benziodaronum
  • Benziodaronum [INN-Latin]
  • Benzofuran, 3-(3,5-diiodo-4-hydroxybenzoyl)-2-ethyl-
  • BRN 1257683
  • Cardivix
  • Carofam
  • Corofam
  • Coronal-crinos
  • Dila-Vasal
  • Dilacoron
  • Dilafurane
  • EINECS 200-695-2
  • Flanicone
  • L 2329
  • NSC 82133
  • Plexocardio
  • Retrangor
  • UNII-75CL65GTYR
  • Uricor

Systematic Names

  • 2-Ethyl-3-benzofuranyl 4-hydroxy-3,5-diiodophenyl ketone
  • Benziodarone
  • Ketone, 2-ethyl-3-benzofuranyl 4-hydroxy-3,5-diiodophenyl (8CI)
  • Ketone, 3,5-diiodo-4-hydroxyphenyl 2-ethyl-3-benzofuranyl
  • Methanone, (2-ethyl-3-benzofuranyl)(4-hydroxy-3,5-diiodophenyl)- (9CI)

Registry Numbers

CAS Registry Number

  • 68-90-6

FDA UNII

  • 75CL65GTYR

System Generated Number

  • 0000068906

Structure Descriptors

InChI

1S/C17H12I2O3/c1-2-13-15(10-5-3-4-6-14(10)22-13)16(20)9-7-11(18)17(21)12(19)8-9/h3-8,21H,2H2,1H3

InChIKey

CZCHIEJNWPNBDE-UHFFFAOYSA-N

Smiles

CCc1c(c2ccccc2o1)C(=O)c3cc(c(c(c3)I)O)I

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 10mg/kg (10mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 1388, 1965.
mouse LD50 intraperitoneal 130mg/kg (130mg/kg)   Yakkyoku. Pharmacy. Vol. 24, Pg. 431, 1973.
mouse LD50 oral 450mg/kg (450mg/kg)   Yakkyoku. Pharmacy. Vol. 24, Pg. 431, 1973.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 167 deg C   EXP
log P (octanol-water) 6.590 (none)   EST
Water Solubility 4.95E-03 mg/L 25 EST
Vapor Pressure 1.49E-11 mm Hg 25 EST
Henry's Law Constant 1.55E-12 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 4.17E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.