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Substance Name: Ceftriaxone [USAN:INN:JAN]
RN: 73384-59-5
UNII: 75J73V1629
InChIKey: VAAUVRVFOQPIGI-SPQHTLEESA-N

Note

  • A broad-spectrum cephalosporin antibiotic and cefotaxime derivative with a very long half-life and high penetrability to meninges, eyes and inner ears.

Molecular Formula

  • C18-H18-N8-O7-S3

Molecular Weight

  • 554.5872
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antibacterial
  • Antiviral (COVID-19)

Names and Synonyms

Results Name

  • Ceftriaxone [USAN:INN:JAN]

Name of Substance

  • Ceftriaxone
  • Ceftriaxone [USAN:INN:JAN]

MeSH Heading

  • Ceftriaxone

Synonyms

  • Biotrakson
  • Ceftriaxona
  • Ceftriaxona [INN-Spanish]
  • Ceftriaxone
  • Ceftriaxone and dextrose in duplex container
  • Ceftriaxonum
  • Ceftriaxonum [INN-Latin]
  • DRG-0071
  • EINECS 277-405-6
  • Ro 139904
  • Rocephin
  • UNII-75J73V1629

Systematic Names

  • 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxo-3-(((1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio)methyl)-, (6R-(6alpha,7beta(Z)))-
  • 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxo-3-(((1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio)methyl)-, (6R,7R)-
  • Ceftriaxone

Registry Numbers

CAS Registry Number

  • 73384-59-5

FDA UNII

  • 75J73V1629

Related Registry Numbers

  • 104376-79-6 (di-hydrochloride salt)
  • 74578-69-1 (di-hydrochloride salt, hemiheptahydrate)

System Generated Number

  • 0073384595

Structure Descriptors

InChI

InChI=1S/C18H18N8O7S3/c1-25-18(22-12(28)13(29)23-25)36-4-6-3-34-15-9(14(30)26(15)10(6)16(31)32)21-11(27)8(24-33-2)7-5-35-17(19)20-7/h5,9,15H,3-4H2,1-2H3,(H2,19,20)(H,21,27)(H,23,29)(H,31,32)/b24-8-/t9-,15-/m1/s1

InChIKey

VAAUVRVFOQPIGI-SPQHTLEESA-N

Smiles

CO\N=C(/C(=O)N[C@H]1[C@H]2SCC(=C(N2C1=O)C(=O)O)CSC3=NC(=O)C(=NN3C)O)\c4csc(N)n4

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo intramuscular 14286ug/kg (14.286mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)		 Allergy. Vol. 55, Pg. 415, 2000.