Skip Navigation
ChemIDplus Lite•Browse•Advanced

Substance Name: Flunisolide [INN]
RN: 3385-03-3
UNII: 78M02AA8KF
InChIKey: XSFJVAJPIHIPKU-XWCQMRHXSA-N

Note

  • Flunisolide HFA is a formulation of flunisolide using hydrofluoroalkane (HFA) as propellant in place of chlorofluorocarbon (CFC) ones.

Molecular Formula

  • C24-H31-F-O6

Molecular Weight

  • 434.5009
 

Classification Codes

  • Anti-Asthmatic Agents
  • Anti-Inflammatory Agents
  • Human Data
  • Reproductive Effect
  • Respiratory System Agents
* denotes mobile formatted website

Links to Resources

NLM Resources (File Locators)

Regulatory Agencies (Superlist Locators)

Other Resources (Internet Locators)


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Flunisolide
  • Flunisolide [INN]

Synonyms

  • Aerobid
  • Aerobid M
  • Aerospan
  • Aerospan HFA
  • Bronalide
  • EINECS 222-193-2
  • Flunisolida
  • Flunisolida [INN-Spanish]
  • Flunisolide
  • Flunisolide HFA
  • Flunisolidum
  • Flunisolidum [INN-Latin]
  • Lunis
  • lunisolide anhydrous
  • Nasalide
  • Nasarel
  • Nisolid
  • Rhinalar
  • RS 3999
  • Soluzione
  • Synaclyn
  • Syntaris
  • UNII-78M02AA8KF

Systematic Names

  • 6alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16, 17-acetal with acetone
  • Flunisolide
  • Pregna-1,4-diene-3,20-dione, 6-alpha-fluoro-11-beta,16-alpha,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone
  • Pregna-1,4-diene-3,20-dione, 6-fluoro-11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-, (6alpha,11beta,16alpha)-

Superlist Name

  • Flunisolide

Registry Numbers

CAS Registry Number

  • 3385-03-3

FDA UNII

  • 78M02AA8KF

System Generated Number

  • 0003385033

Structure Descriptors

InChI

InChI=1S/C24H31FO6/c1-21(2)30-19-9-14-13-8-16(25)15-7-12(27)5-6-22(15,3)20(13)17(28)10-23(14,4)24(19,31-21)18(29)11-26/h5-7,13-14,16-17,19-20,26,28H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,20+,22-,23-,24+/m0/s1

InChIKey

XSFJVAJPIHIPKU-XWCQMRHXSA-N

Smiles

CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TCLo inhalation 21mg/kg/30W-I (21mg/kg) SENSE ORGANS AND SPECIAL SENSES: DEVIATED NASAL SEPTUM: OLFACTION

SENSE ORGANS AND SPECIAL SENSES: ULCERATED NASAL SEPTUM: OLFACTION		 Journal of Pediatrics. Vol. 105, Pg. 840, 1984.
mouse LD50 intravenous > 76ug/kg (0.076mg/kg) BLOOD: APLASTIC ANEMIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 501, 1984.
mouse LD50 oral > 500ug/kg (0.5mg/kg) BLOOD: APLASTIC ANEMIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 501, 1984.
mouse LD50 subcutaneous > 290ug/kg (0.29mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BLOOD: APLASTIC ANEMIA		 Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 501, 1984.
rat LD50 intravenous > 51mg/kg (51mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 501, 1984.
rat LD50 intravenous > 51mg/kg (51mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BLOOD: APLASTIC ANEMIA		 Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 501, 1984.
rat LD50 oral > 500ug/kg (0.5mg/kg) BLOOD: APLASTIC ANEMIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 501, 1984.
rat LD50 subcutaneous > 46mg/kg (46mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BLOOD: APLASTIC ANEMIA		 Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 501, 1984.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 2.660 (none)   EST
Atmospheric OH Rate Constant 8.43E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.