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Substance Name: Amiloride hydrochloride anhydrous
RN: 2016-88-8
UNII: 7M458Q65S3
InChIKey: ACHKKGDWZVCSNH-UHFFFAOYSA-N

Note

  • A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)

Molecular Formula

  • C6-H8-Cl-N7-O.Cl-H

Molecular Weight

  • 266.091
 

Classification Code

  • Mutation Data
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Names and Synonyms

Name of Substance

  • Amiloride hydrochloride anhydrous

Synonyms

  • Amiloride chloride
  • Amiloride HCl
  • Amiloride hydrochloride
  • CCRIS 5959
  • EINECS 217-958-2
  • UNII-7M458Q65S3

Systematic Names

  • Amiloride hydrochloride
  • N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide monohydrochloride
  • Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, monohydrochloride
  • Pyrazinecarboxamide, N-amidino-3,5-diamino-6-chloro-, monohydrochloride

Registry Numbers

CAS Registry Number

  • 2016-88-8

FDA UNII

  • 7M458Q65S3

Related Registry Number

  • 2609-46-3 (Parent)

System Generated Number

  • 0002016888

Molecular Formulas

Molecular Formula

  • C6-H8-Cl-N7-O.Cl-H

Molecular Formula Fragments

  • C6-H8-Cl-N7-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C6H8ClN7O.ClH/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;/h(H4,8,9,13)(H4,10,11,14,15);1H

InChIKey

ACHKKGDWZVCSNH-UHFFFAOYSA-N

Smiles

c1(C(NC(N)=N)=O)c(nc(N)c(n1)Cl)N.Cl