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Substance Name: Levomoramide [INN:BAN:DCF]
RN: 5666-11-5
UNII: 7M86YFN15D
InChIKey: INUNXTSAACVKJS-NRFANRHFSA-N

Note

  • Stereoisomer of DEXTROMORAMIDE.

Molecular Formula

  • C25-H32-N2-O2

Molecular Weight

  • 392.5398
 

Classification Codes

Classification Code

  • Drug / Therapeutic Agent

Superlist Classification Code

  • DEA Schedule I
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Names and Synonyms

Name of Substance

  • Levomoramide
  • Levomoramide [INN:BAN:DCF]

Synonyms

  • (-)-2,2-Diphenyl-3-methyl-4-morpholinobutyrylpyrrolidine
  • (-)-4-(2-Methyl-4-oxo-3,3-diphenyl-4-(1-pyrrolidinyl)butyl)morpholine
  • EINECS 227-123-4
  • Levomoramida
  • Levomoramida [INN-Spanish]
  • Levomoramide
  • Levomoramidum
  • Levomoramidum [INN-Latin]
  • Levoramide
  • R 898
  • UNII-7M86YFN15D

Systematic Names

  • (-)-4-(2-Methyl-4-oxo-3,3-diphenyl-4-(1-pyrrolidinyl)butyl)morpholine
  • Levomoramide
  • Pyrrolidine, 1-(2,2-diphenyl-3-methyl-4-morpholinobutyryl)-, (-)-
  • Pyrrolidine, 1-(3-methyl-4-(4-morpholinyl)-1-oxo-2,2-diphenylbutyl)-, (R)- (9CI)

Superlist Names

  • DEA No. 9629
  • Levomoramide

Registry Numbers

CAS Registry Number

  • 5666-11-5

FDA UNII

  • 7M86YFN15D

System Generated Number

  • 0005666115

Structure Descriptors

InChI

1S/C25H32N2O2/c1-21(20-26-16-18-29-19-17-26)25(22-10-4-2-5-11-22,23-12-6-3-7-13-23)24(28)27-14-8-9-15-27/h2-7,10-13,21H,8-9,14-20H2,1H3/t21-/m0/s1

InChIKey

INUNXTSAACVKJS-NRFANRHFSA-N

Smiles

C[C@@H](CN1CCOCC1)C(C(=O)N2CCCC2)(c3ccccc3)c4ccccc4

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 30500ug/kg (30.5mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Journal of Pharmacy and Pharmacology. Vol. 9, Pg. 730, 1957.
mouse LD50 oral 1gm/kg (1000mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacy and Pharmacology. Vol. 9, Pg. 730, 1957.
mouse LD50 subcutaneous 330mg/kg (330mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacy and Pharmacology. Vol. 9, Pg. 730, 1957.
rat LD50 intraperitoneal 162mg/kg (162mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Journal of Pharmacy and Pharmacology. Vol. 9, Pg. 730, 1957.
rat LD50 intravenous 37mg/kg (37mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of Pharmacy and Pharmacology. Vol. 9, Pg. 730, 1957.
rat LD50 subcutaneous > 640mg/kg (640mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Journal of Pharmacy and Pharmacology. Vol. 9, Pg. 730, 1957.