Substance Name: Dexamethasone [USP:INN:BAN:JAN]
RN: 50-02-2
UNII: 7S5I7G3JQL
InChIKey: UREBDLICKHMUKA-CXSFZGCWSA-N

Note

An anti-inflammatory 9-fluoro-glucocorticoid.

Molecular Formula

C22-H29-F-O5

Molecular Weight

392.4641

All
Classifications
Links to Resources
Names & Synonyms
Registry Numbers
Structure Descriptors
Toxicity
Physical Properties

Classification Codes

Adrenal Cortex Hormones
Anti-Inflammatory Agents
Antiemetics
Antineoplastic Agents
Antineoplastic Agents, Hormonal

Autonomic Agents
Central Nervous System Agents
Drug / Therapeutic Agent
Gastrointestinal Agents
Glucocorticoid

Glucocorticoids
Hormone
Hormones
Hormones, Hormone Substitutes, and Hormone Antagonists
Human Data

Immunomodulator
Mutation Data
Peripheral Nervous System Agents
Reproductive Effect

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Names and Synonyms

Name of Substance

Dexamethasone

Dexamethasone [USP:INN:BAN:JAN]

MeSH Heading

Dexamethasone

Synonyms

(11beta,16alpha)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone
16-alpha-Methyl-9-alpha-fluoro-1,4-pregnadiene-11-beta,17-alpha,21-triol-3,20-dione
16-alpha-Methyl-9-alpha-fluoro-1-dehydrocortisol
16-alpha-Methyl-9-alpha-fluoro-11-beta,17-alpha,21-trihydroxypregna-1,4-diene-3,20-dione
16-alpha-Methyl-9-alpha-fluoro-delta(sup 1)-hydrocortisone
16-alpha-Methyl-9-alpha-fluoro-delta1-hydrocortisone
16-alpha-Methyl-9-alpha-fluoroprednisolone
16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol
16alpha-Methyl-9alpha-fluoro-delta(sup 1)-hydrocortisone
16alpha-Methyl-9alpha-fluoroprednisolone
4-alpha-Fluoro-16-alpha-methyl-11-beta,17,21-trihydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-16-alpha-methyl-1,4-pregnadiene-11-beta,17-alpha,21-triol-3,20-dione
9-alpha-Fluoro-16-alpha-methylprednisolone
9-Fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione
9alpha-Fluoro-16alpha-methylprednisolone
Aeroseb-D
Aeroseb-Dex
AI3-50934
Anaflogistico
Aphtasolon
Auxiron
Azium
Bisu DS
Calonat
CCRIS 7067
Corsone
Cortisumman
Decacortin
Decaderm
Decadron
Decadron Tablets, Elixir
Decagel
Decaject

Decaject-L.A.
Decalix
Decameth
Decasone
Decaspray
Dectancyl
Dekacort
delta(sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
delta1-9alpha-Fluoro-16alpha-methylcortisol
Deltafluorene
Dergramin
Deronil
Desadrene
Desametasone
Desametasone [DCIT]
Desamethasone
Desameton
Deseronil
Dex-ide
Dexa Mamallet
Dexa-Cortidelt
Dexa-Cortisyl
Dexa-Scheroson
Dexa-sine
Dexacort
Dexacortal
Dexacortin
Dexadeltone
Dexafarma
Dexalona
Dexametasona
Dexametasona [INN-Spanish]
Dexameth
Dexamethasone

Dexamethasone alcohol
Dexamethasone Intensol
Dexamethasone, topical
Dexamethasonum
Dexamethasonum [INN-Latin]
Dexamethazone
Dexapolcort
Dexapos
Dexaprol
Dexason
Dexasone
Dexinolon
Dexinoral
Dexone
Dexone 0.5
Dexone 0.75
Dexone 1.5
Dexone 4
DexPak
Dextelan
Dextenza
Dezone
Dinormon
DXM [Steroid]
DXMS
EINECS 200-003-9
Fluormethylprednisolone
Fluormone
Fluorocort
Fortecortin
Gammacorten
Hexadecadrol
Hexadrol
Hexadrol Elixir

Hexadrol Tablets
HL-Dex
HSDB 3053
Isopto-Dex
Lokalison F
Loverine
Luxazone
Maxidex
Mediamethasone
Methylfluorprednisolone
Mexidex
Millicorten
MK 125
Mymethasone
NSC 34521
Ocu-trol
Oradexon
Osurdex
OTO-104
Ozurdex
Pet Derm III
Policort
Prednisolon F
Prednisolone F
Prednisolone, 9alpha-fluoro-16alpha-methyl-
SK-Dexamethasone
Spoloven
Sunia Sol D
Superprednol
Turbinaire
UNII-7S5I7G3JQL
Visumetazone

Systematic Names

Dexamethasone

Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11beta,16alpha)-

Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy-16alpha-methyl-

Mixture Names

Azimycin (Veterinary)
Azium (Veterinary)
Deronil

Dexacidin
Fulvidex (Veterinary)
Maxitrol

Naquasone (Veterinary)
Posurdex
Tobradex

Tresaderm (Veterinary)

Registry Numbers

CAS Registry Number

50-02-2

FDA UNII

7S5I7G3JQL

Other Registry Numbers

1050677-47-8
137098-19-2

8054-59-9
906362-70-7

906422-84-2

System Generated Number

0000050022

Structure Descriptors

InChI

InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

InChIKey

UREBDLICKHMUKA-CXSFZGCWSA-N

Smiles

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	410mg/kg (410mg/kg)		Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 281, 1970.
mouse	LD50	subcutaneous	4400mg/kg (4400mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 2117, 1979.
rabbit	LD50	subcutaneous	7200ug/kg (7.2mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE	Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 687, 1984.
rat	LD50	intraperitoneal	54mg/kg (54mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 687, 1984.
rat	LD50	oral	> 3gm/kg (3000mg/kg)		Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 687, 1984.
rat	LD50	subcutaneous	14mg/kg (14mg/kg)		Toxicology and Applied Pharmacology. Vol. 8, Pg. 250, 1966.
women	TDLo	multiple routes	4759ug/kg/18D (4.759mg/kg)	KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED	Intensive Care Medicine. Vol. 21, Pg. 238, 1995.

Physical Properties

Physical Property	Value	Units	Temp (deg C)	Source
Melting Point	262	deg C		EXP
log P (octanol-water)	1.83	(none)		EXP
Water Solubility	89	mg/L	25	EXP
Vapor Pressure	8.86E-14	mm Hg	25	EST
Henry's Law Constant	7.15E-08	atm-m3/mole	25	EST
Atmospheric OH Rate Constant	6.95E-11	cm3/molecule-sec	25	EST

Physical property data is provided to ChemIDplus by SRC, Inc.

Substance Name: Dexamethasone [USP:INN:BAN:JAN]RN: 50-02-2UNII: 7S5I7G3JQLInChIKey: UREBDLICKHMUKA-CXSFZGCWSA-N