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Substance Name: Dexamethasone [USP:INN:BAN:JAN]
RN: 50-02-2
UNII: 7S5I7G3JQL
InChIKey: UREBDLICKHMUKA-CXSFZGCWSA-N
Note
- An anti-inflammatory 9-fluoro-glucocorticoid.
Molecular Formula
- C22-H29-F-O5
Molecular Weight
- 392.4641
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Adrenal Cortex Hormones
- Anti-Inflammatory Agents
- Antiemetics
- Antineoplastic Agents
- Antineoplastic Agents, Hormonal
- Antiviral (COVID-19)
- Autonomic Agents
- Central Nervous System Agents
- Drug / Therapeutic Agent
- Gastrointestinal Agents
- Glucocorticoid
- Glucocorticoids
- Hormone
- Hormones
- Hormones, Hormone Substitutes, and Hormone Antagonists
- Human Data
- Immunomodulator
- Mutation Data
- Peripheral Nervous System Agents
- Reproductive Effect
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Other Resources (Internet Locators)
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Names and Synonyms
Name of Substance
- Dexamethasone
- Dexamethasone [USP:INN:BAN:JAN]
MeSH Heading
- Dexamethasone
Synonyms
- (11beta,16alpha)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
- 1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone
- 16-alpha-Methyl-9-alpha-fluoro-1,4-pregnadiene-11-beta,17-alpha,21-triol-3,20-dione
- 16-alpha-Methyl-9-alpha-fluoro-1-dehydrocortisol
- 16-alpha-Methyl-9-alpha-fluoro-11-beta,17-alpha,21-trihydroxypregna-1,4-diene-3,20-dione
- 16-alpha-Methyl-9-alpha-fluoro-delta(sup 1)-hydrocortisone
- 16-alpha-Methyl-9-alpha-fluoro-delta1-hydrocortisone
- 16-alpha-Methyl-9-alpha-fluoroprednisolone
- 16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol
- 16alpha-Methyl-9alpha-fluoro-delta(sup 1)-hydrocortisone
- 16alpha-Methyl-9alpha-fluoroprednisolone
- 4-alpha-Fluoro-16-alpha-methyl-11-beta,17,21-trihydroxypregna-1,4-diene-3,20-dione
- 9-alpha-Fluoro-16-alpha-methyl-1,4-pregnadiene-11-beta,17-alpha,21-triol-3,20-dione
- 9-alpha-Fluoro-16-alpha-methylprednisolone
- 9-Fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione
- 9alpha-Fluoro-16alpha-methylprednisolone
- Aeroseb-D
- Aeroseb-Dex
- AI3-50934
- Anaflogistico
- Aphtasolon
- Auxiron
- Azium
- Bisu DS
- Calonat
- CCRIS 7067
- Corsone
- Cortisumman
- Decacortin
- Decaderm
- Decadron
- Decadron Tablets, Elixir
- Decagel
- Decaject
- Decaject-L.A.
- Decalix
- Decameth
- Decasone
- Decaspray
- Dectancyl
- Dekacort
- delta(sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
- delta1-9alpha-Fluoro-16alpha-methylcortisol
- Deltafluorene
- Dergramin
- Deronil
- Desadrene
- Desametasone
- Desametasone [DCIT]
- Desamethasone
- Desameton
- Deseronil
- Dex-ide
- Dexa Mamallet
- Dexa-Cortidelt
- Dexa-Cortisyl
- Dexa-Scheroson
- Dexa-sine
- Dexacort
- Dexacortal
- Dexacortin
- Dexadeltone
- Dexafarma
- Dexalona
- Dexametasona
- Dexametasona [INN-Spanish]
- Dexameth
- Dexamethasone
- Dexamethasone alcohol
- Dexamethasone Intensol
- Dexamethasone, topical
- Dexamethasonum
- Dexamethasonum [INN-Latin]
- Dexamethazone
- Dexapolcort
- Dexapos
- Dexaprol
- Dexason
- Dexasone
- Dexinolon
- Dexinoral
- Dexone
- Dexone 0.5
- Dexone 0.75
- Dexone 1.5
- Dexone 4
- DexPak
- Dextelan
- Dextenza
- Dezone
- Dinormon
- DXM [Steroid]
- DXMS
- EINECS 200-003-9
- Fluormethylprednisolone
- Fluormone
- Fluorocort
- Fortecortin
- Gammacorten
- Hexadecadrol
- Hexadrol
- Hexadrol Elixir
- Hexadrol Tablets
- HL-Dex
- HSDB 3053
- Isopto-Dex
- Lokalison F
- Loverine
- Luxazone
- Maxidex
- Mediamethasone
- Methylfluorprednisolone
- Mexidex
- Millicorten
- MK 125
- Mymethasone
- NSC 34521
- Ocu-trol
- Oradexon
- Osurdex
- OTO-104
- Ozurdex
- Pet Derm III
- Policort
- Prednisolon F
- Prednisolone F
- Prednisolone, 9alpha-fluoro-16alpha-methyl-
- SK-Dexamethasone
- Spoloven
- Sunia Sol D
- Superprednol
- Turbinaire
- UNII-7S5I7G3JQL
- Visumetazone
Systematic Names
- Dexamethasone
- Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11beta,16alpha)-
- Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy-16alpha-methyl-
Mixture Names
- Azimycin (Veterinary)
- Azium (Veterinary)
- Deronil
- Dexacidin
- Fulvidex (Veterinary)
- Maxitrol
- Naquasone (Veterinary)
- Posurdex
- Tobradex
- Tresaderm (Veterinary)
Registry Numbers
CAS Registry Number
- 50-02-2
FDA UNII
- 7S5I7G3JQL
Other Registry Numbers
- 1050677-47-8
- 137098-19-2
- 8054-59-9
- 906362-70-7
- 906422-84-2
System Generated Number
- 0000050022
Structure Descriptors
InChI
InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1InChIKey
UREBDLICKHMUKA-CXSFZGCWSA-NSmiles
C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 410mg/kg (410mg/kg) | Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 281, 1970. | |
mouse | LD50 | subcutaneous | 4400mg/kg (4400mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 2117, 1979. | |
rabbit | LD50 | subcutaneous | 7200ug/kg (7.2mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE | Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 687, 1984. |
rat | LD50 | intraperitoneal | 54mg/kg (54mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 687, 1984. |
rat | LD50 | oral | > 3gm/kg (3000mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 687, 1984. | |
rat | LD50 | subcutaneous | 14mg/kg (14mg/kg) | Toxicology and Applied Pharmacology. Vol. 8, Pg. 250, 1966. | |
women | TDLo | multiple routes | 4759ug/kg/18D (4.759mg/kg) | KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED | Intensive Care Medicine. Vol. 21, Pg. 238, 1995. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 262 | deg C | EXP | |
log P (octanol-water) | 1.83 | (none) | EXP | |
Water Solubility | 89 | mg/L | 25 | EXP |
Vapor Pressure | 8.86E-14 | mm Hg | 25 | EST |
Henry's Law Constant | 7.15E-08 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 6.95E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.