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Substance Name: Profenamine [INN:BAN]
RN: 522-00-9
UNII: 7WI4P02YN1
InChIKey: CDOZDBSBBXSXLB-UHFFFAOYSA-N

Molecular Formula

  • C19-H24-N2-S

Molecular Weight

  • 312.4786
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic Antagonists
  • Cholinergic Agents
  • Cholinergic Antagonists
  • Drug / Therapeutic Agent
  • Histamine Agents
  • Histamine Antagonists
  • Muscarinic Antagonists
  • Neurotransmitter Agents
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Names and Synonyms

Results Name

  • Profenamine [INN:BAN]

Name of Substance

  • Ethopropazine
  • Profenamine
  • Profenamine [INN:BAN]

Synonyms

  • 10-(2-Diethylaminopropyl)phenothiazine
  • 2-Diethylamino-1-propyl-N-dibenzoparathiazine
  • EINECS 208-320-4
  • Ethopromazine
  • Ethopropazine
  • Isothazine
  • Isothiazine
  • N,N-Diethyl-alpha-methyl-10H-phenothiazine-10-ethanamine
  • Parfezine
  • Parkin
  • Parsidol
  • Parsitan
  • Parsotil
  • Phenopropazine
  • Profenamina
  • Profenamina [INN-Spanish]
  • Profenamina [Italian]
  • Profenamine
  • Profenaminum
  • Profenaminum [INN-Latin]
  • Prophenamine
  • Prophenaminum
  • Rodipal
  • RP 3356
  • SC 2538
  • SKF 2538
  • UNII-7WI4P02YN1
  • W 483

Systematic Names

  • 10H-Phenothiazine-10-ethanamine, N,N-diethyl-alpha-methyl-
  • Phenothiazine, 10-(2-(diethylamino)propyl)-
  • Profenamine

Registry Numbers

CAS Registry Number

  • 522-00-9

FDA UNII

  • 7WI4P02YN1

System Generated Number

  • 0000522009

Structure Descriptors

InChI

InChI=1S/C19H24N2S/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21/h6-13,15H,4-5,14H2,1-3H3

InChIKey

CDOZDBSBBXSXLB-UHFFFAOYSA-N

Smiles

CCN(CC)C(C)CN1c2ccccc2Sc3ccccc13

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 50mg/kg (50mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 41, 1972.
mouse LD50 oral 300mg/kg (300mg/kg)   Bollettino Chimico Farmaceutico. Vol. 111, Pg. 293, 1972.
mouse LD50 subcutaneous 500mg/kg (500mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 41, 1972.
rabbit LD50 intravenous 15mg/kg (15mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 41, 1972.
rabbit LD50 subcutaneous 200mg/kg (200mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 41, 1972.
rat LD50 intravenous 15mg/kg (15mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 41, 1972.
rat LD50 subcutaneous 200mg/kg (200mg/kg)   Psychopharmacology Service Center, Bulletin. Vol. 2, Pg. 17, 1963.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 64.5 deg C   EXP
log P (octanol-water) 4.77 (none)   EXP
Water Solubility 0.693 mg/L 25 EST
Vapor Pressure 2.52E-07 mm Hg 25 EST
Henry's Law Constant 8.77E-10 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.97E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.