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Substance Name: Amoxicillin [USAN:USP:INN:BAN:JAN]
RN: 61336-70-7
UNII: 804826J2HU
InChIKey: MQXQVCLAUDMCEF-CWLIKTDRSA-N
Note
- A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.
Molecular Formula
- C16-H19-N3-O5-S.3H2-O
Molecular Weight
- 419.4525
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Codes
- Anti-Bacterial Agents
- Anti-Infective Agents
- Antibacterial
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Amoxicillin [USAN:USP:INN:BAN:JAN]
MeSH Heading
- Amoxicillin
Synonyms
- (2S,5R,6R)-6-((R)-(-)-2-Amino-2-(p-hydroxyphenyl)acetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid trihydrate
- 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((amino(4-hydroxyphenyl)acetyl)amino)-3,3-dimethyl-7-oxo-, trihydrate(2S-(2alpha,5alpha,6beta(S*)))-
- A-Gram
- Alfamox
- alpha-Amino-p-hydroxybenzylpenicillin trihydrate
- AM 7
- Amodex
- Amoksicillin
- Amoksicillin forte
- Amophar
- Amoran
- Amoxi-Diolan
- Amoxi-wolff
- Amoxicillin
- Amoxicillin trihydrate
- Amoxicillin-ratiopharm
- Amoxidal
- Amoxil
- Amoxillat
- Amoxina
- Amoxine
- Amoxipen
- Benzoral
- BRL 2333
- Ciblor
- Clamoxyl
- Dispermox
- Drg-0075
- Dura AX
- Flemoxine
- Galenamox
- Gramidil
- Hiconcil
- Himinomax
- Imacillin
- Izoltil
- Kentrocyllin
- Larotid
- Matasedrin
- Metifarma
- Moxal
- Moxaline
- Novabritine
- Pacetocin
- Pamocil
- Paradroxil
- Polymox
- Robamox
- Siganopen
- Simplamox
- Sintopen
- Trimox
- UNII-804826J2HU
- Uro-clamoxyl
- Utimox
- Velamox
- Wymox
- Zamocillin
- Zamocilline
- Zimox
Systematic Names
- 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(((2R)-amino(4-hydroxyphenyl)acetyl)amino)-3,3-dimethyl-7-oxo-, trihydrate, (2S,5R,6R)-
- 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((amino(4-hydroxyphenyl)acetyl)amino)-3,3-dimethyl-7-oxo-, trihydrate (2S-(2alpha,5alpha,6beta(S*)))-
Mixture Name
- Augmentin
Registry Numbers
CAS Registry Number
- 61336-70-7
FDA UNII
- 804826J2HU
Related Registry Number
- 26787-78-0 (Parent)
System Generated Number
- 0061336707
Molecular Formulas
Molecular Formula
- C16-H19-N3-O5-S.3H2-O
Molecular Formula Fragments
- C16-H19-N3-O5-S
- COMPONENT
- H2-O
Structure Descriptors
InChI
InChI=1S/C16H19N3O5S.3H2O/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7;;;/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24);3*1H2/t9-,10-,11+,14-;;;/m1.../s1InChIKey
MQXQVCLAUDMCEF-CWLIKTDRSA-NSmiles
O.O.O.CC1(C)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 3590mg/kg (3590mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 3040, 1973. |
mouse | LD50 | oral | > 25gm/kg (25000mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 3040, 1973. | |
mouse | LD50 | subcutaneous | > 20gm/kg (20000mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 3040, 1973. | |
rabbit | LD50 | oral | > 12500mg/kg (12500mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 3040, 1973. | |
rat | LD50 | intraperitoneal | 2870mg/kg (2870mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 3040, 1973. |
rat | LD50 | oral | > 15gm/kg (15000mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 3040, 1973. | |
rat | LD50 | subcutaneous | > 8gm/kg (8000mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 3040, 1973. |