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Substance Name: Dihydroergotamine mesylate [USAN:USP]
RN: 6190-39-2
UNII: 81AXN7R2QT
InChIKey: ADYPXRFPBQGGAH-UMYZUSPBSA-N
Note
- A 9,10alpha-dihydro derivative of ERGOTAMINE. It is used as a vasoconstrictor, specifically for the therapy of MIGRAINE DISORDERS.
Molecular Formula
- C33-H37-N5-O5.C-H4-O3-S
Molecular Weight
- 679.7909
- All
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- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Codes
- Anti-Adrenergic
- Drug / Therapeutic Agent
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Names and Synonyms
Name of Substance
- Dihydroergotamine mesylate [USAN:USP]
Synonyms
- 9,10-Dihydroergotamine mesylate
- D.H.E. 45
- DETMS
- DHE-45
- Dihydergot
- Dihydroergotamine mesilate
- Dihydroergotamine mesylate
- Dihydroergotamine methanesulfonate
- Dihydroergotamine monomethanesulfonate
- Dihytamine
- EINECS 228-235-6
- Migranal
- MT 300
- UNII-81AXN7R2QT
Systematic Names
- Dihydroergotamine mesilate
- Ergotamine, 9,10-dihydro-, monomethanesulfonate (salt)
- Ergotoman-3',6',18-trione,9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'alpha)-, monomethanesulfonate (salt)
Superlist Name
- Dihydroergotamine mesylate
Registry Numbers
CAS Registry Number
- 6190-39-2
FDA UNII
- 81AXN7R2QT
Related Registry Number
- 511-12-6 (Parent)
System Generated Number
- 0006190392
Molecular Formulas
Molecular Formula
- C33-H37-N5-O5.C-H4-O3-S
Molecular Formula Fragments
- C-H4-O3-S
- C33-H37-N5-O5
- COMPONENT
Structure Descriptors
InChI
1S/C33H37N5O5.CH4O3S/c1-32(35-29(39)21-15-23-22-10-6-11-24-28(22)20(17-34-24)16-25(23)36(2)18-21)31(41)38-26(14-19-8-4-3-5-9-19)30(40)37-13-7-12-27(37)33(38,42)43-32;1-5(2,3)4/h3-6,8-11,17,21,23,25-27,34,42H,7,12-16,18H2,1-2H3,(H,35,39);1H3,(H,2,3,4)/t21-,23-,25-,26+,27+,32-,33+;/m1./s1InChIKey
ADYPXRFPBQGGAH-UMYZUSPBSA-NSmiles
C[C@@]1(C(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | oral | > 2gm/kg (2000mg/kg) | Drugs in Japan Vol. -, Pg. 468, 1990. | |
rabbit | LD50 | oral | > 1gm/kg (1000mg/kg) | Drugs in Japan Vol. 6, Pg. 328, 1982. | |
rat | LD50 | oral | > 2gm/kg (2000mg/kg) | Drugs in Japan Vol. -, Pg. 468, 1990. |