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Substance Name: Carbazochrome [INN:JAN]
RN: 69-81-8
UNII: 81F061RQS4
InChIKey: XSXCZNVKFKNLPR-SDQBBNPISA-N

Note

  • A hemostatic which increases capillary resistance & activates platelet factors.

Molecular Formula

  • C10-H12-N4-O3

Molecular Weight

  • 236.2298
 

Classification Codes

  • Coagulants
  • Hematologic Agents
  • Hemostatics
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Names and Synonyms

Name of Substance

  • Carbazochrome
  • Carbazochrome [INN:JAN]

Synonyms

  • 3-Hydroxy-1-methyl-5,6-inodlindionsemicarbazon
  • 3-Hydroxy-1-methyl-5-semicarbazono-6(5H)-indolinon
  • Adchnon
  • Adedolon
  • Adenocrome monosemicarbazone
  • Adrenochrome monosemicarbazon
  • Adrenochrome monosemicarbazone
  • Adrenochrome semicarbazone
  • Adrenostan
  • Adrenostazin
  • Adrenoxil
  • Adrenoxyl
  • Adrezon
  • Adrokson
  • Adroxon
  • Apara
  • Carbazochrom
  • Carbazochrome
  • Carbazochromum
  • Carbazochromum [INN-Latin]
  • Carbazocromo
  • Carbazocromo [INN-Spanish]
  • Cartabes
  • Cromadrenal
  • Cromosil
  • Cromoxin
  • EINECS 200-717-0
  • Hydrazinecarboxamide, 2-(1,2,3,6-tetrahydro-3-hydroxy-1-methyl-6-oxo-5H-indol-5-ylidene)-
  • L 502
  • NSC 73742
  • Sangostasin
  • Sangostazin
  • UNII-81F061RQS4

Systematic Names

  • 3-Hydroxy-1-methyl-5,6-indolinedione semicarbazone
  • 5,6-Indolinedione, 3-hydroxy-1-methyl-, 5-semicarbazone
  • Carbazochrome
  • Hydrazinecarboxamide, 2-(1,2,3,6-tetrahydro-3-hydroxy-1-methyl-6-oxo-5H-indol-5-ylidene)-

Registry Numbers

CAS Registry Number

  • 69-81-8

FDA UNII

  • 81F061RQS4

System Generated Number

  • 0000069818

Structure Descriptors

InChI

InChI=1S/C10H12N4O3/c1-14-4-9(16)5-2-6(12-13-10(11)17)8(15)3-7(5)14/h2-3,9,16H,4H2,1H3,(H3,11,13,17)/b12-6-

InChIKey

XSXCZNVKFKNLPR-SDQBBNPISA-N

Smiles

CN1CC(O)C2=C\C(=N\NC(=O)N)\C(=O)C=C12

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 2413mg/kg (2413mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 1821, 1978.
mouse LD50 oral > 35832mg/kg (35832mg/kg)   German Offenlegungsschrift Patent Document. Vol. #2808572,
mouse LD50 subcutaneous > 10gm/kg (10000mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 1821, 1978.
rat LD50 intraperitoneal 1276mg/kg (1276mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 1821, 1978.
rat LD50 oral > 17280mg/kg (17280mg/kg)   German Offenlegungsschrift Patent Document. Vol. #2808572,
rat LD50 subcutaneous > 12500mg/kg (12500mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 1821, 1978.