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Substance Name: Paromomycin sulfate [USP:JAN]
RN: 1263-89-4
UNII: 845NU6GJPS
InChIKey: LJRDOKAZOAKLDU-UDXJMMFXSA-N

Note

  • An oligosaccharide antibiotic produced by various STREPTOMYCES.

Molecular Formula

  • C23-H45-N5-O14.x-H2-O4-S

Molecular Weight

  • 713.7073
 

Classification Codes

  • Anthelmintic
  • Anti-Amebic
  • Drug / Therapeutic Agent
  • Mutation Data
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Names and Synonyms

Name of Substance

  • Paromomycin sulfate [USP:JAN]

Synonyms

  • Aminosidin sulfate
  • Aminosidine sulfate
  • Aminosidine sulphate
  • Aminoxidin
  • EINECS 215-031-7
  • Farmiglucin
  • Farminosidin
  • FI 5853
  • Gabbromicina
  • Gabbroral
  • Humagel
  • Humatin
  • Humycin sulfate
  • NSC 758421
  • O-2,6-Diamino-2,6-dideoxy-beta-L-idopyranosyl-(1-3)-O-beta-D-ribofuranosyl-(1-5)-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl-(1-4))-2-deoxystreptamine sulfate (salt)
  • Paromomycin sulfate
  • Sinosid
  • UNII-845NU6GJPS

Systematic Names

  • D-Streptamine, O-2-amino-2-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(O-2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl-(1-3)-beta-D-ribofuranosyl-(1-5))-2-deoxy-, sulfate (salt)
  • D-Streptamine, O-2-amino-2-deoxy-alpha-D-glucopyranosyl-(1.fwdarw.4)-O-(O-2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl-(1.fwdarw.3)-beta-D-ribofuranosyl-(1.fwdarw.5))-2-deoxy-, sulfate (salt)
  • Paromomycin sulphates

Registry Numbers

CAS Registry Number

  • 1263-89-4

FDA UNII

  • 845NU6GJPS

Other Registry Numbers

  • 11048-06-9
  • 1405-13-6
  • 14963-45-2
  • 42438-81-3
  • 51981-74-9

Related Registry Number

  • 7542-37-2 (Parent)

System Generated Number

  • 0001263894

Molecular Formulas

Molecular Formula

  • C23-H45-N5-O14.x-H2-O4-S

Molecular Formula Fragments

  • C23-H45-N5-O14
  • COMPONENT
  • H2-O4-S

Structure Descriptors

InChI

InChI=1S/C23H45N5O14.H2O4S/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;1-5(2,3)4/h5-23,29-36H,1-4,24-28H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1

InChIKey

LJRDOKAZOAKLDU-UDXJMMFXSA-N

Smiles

NC[C@@H]1O[C@H](O[C@H]2[C@@H](O)[C@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4N)O[C@@H]2CO)[C@H](N)[C@@H](O)[C@@H]1O.OS(=O)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 subcutaneous 1700mg/kg (1700mg/kg)   Chemotherapy Vol. 16, Pg. 105, 1968.
monkey LDLo intravenous 93mg/kg (93mg/kg) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Antibiotics and Chemotherapy Vol. 9, Pg. 730, 1959.
mouse LD50 intracrebral 22300ug/kg (22.3mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Chemotherapy Vol. 16, Pg. 114, 1968.
mouse LD50 intramuscular 438mg/kg (438mg/kg)   Japanese Journal of Antibiotics. Vol. 36, Pg. 644, 1983.
mouse LD50 intraperitoneal 750mg/kg (750mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Chemotherapy Vol. 16, Pg. 114, 1968.
mouse LD50 intravenous 90mg/kg (90mg/kg)   Therapie. Vol. 16, Pg. 184, 1961.
mouse LD50 oral 23500mg/kg (23500mg/kg)   Japanese Journal of Antibiotics. Vol. 36, Pg. 644, 1983.
mouse LD50 subcutaneous 123mg/kg (123mg/kg)   Therapie. Vol. 16, Pg. 184, 1961.
rat LD50 intramuscular 1200mg/kg (1200mg/kg)   Drugs in Japan Vol. 6, Pg. 595, 1982.
rat LD50 intravenous 181mg/kg (181mg/kg)   Antibiotics and Chemotherapy Vol. 9, Pg. 730, 1959.
rat LD50 oral 21620mg/kg (21620mg/kg)   Drugs in Japan Vol. 6, Pg. 595, 1982.
rat LD50 subcutaneous 870mg/kg (870mg/kg) PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Chemotherapy Vol. 16, Pg. 114, 1968.