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Substance Name: Bamocaftor [USAN]
RN: 2204245-48-5
UNII: 8C7XEW3K7S
InChIKey: IGEOJNMYRZUKIK-IBGZPJMESA-N

Note

  • A chloride channel corrector for the treatment of cystic fibrosis.

Molecular Formula

  • C28-H32-F3-N5-O4-S

Molecular Weight

  • 591.6518
 

Classification Codes

  • Chloride Channel Agonists
  • Membrane Transport Modulators
  • Treatment of Cystic Fibrosis
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Names and Synonyms

Name of Substance

  • Bamocaftor [USAN]
  • VX-659

Synonyms

  • 3-Pyridinecarboxamide, N-(phenylsulfonyl)-6-(3-(2-(1-(trifluoromethyl)cyclopropyl)ethoxy)-1H-pyrazol-1-yl)-2-((4S)-2,2,4-trimethyl-1-pyrrolidinyl)-
  • Bamocaftor
  • N-(phenylsulfonyl)-6-(3-(2-(1-(trifluoromethyl)cyclopropyl)ethoxy)-1H-pyrazol-1-yl)-2-(2,2,4-trimethyl-1-pyrrolidinyl)nicotinamide
  • UNII-8C7XEW3K7S
  • VX-659
  • VX659
  • WHO 11167

Registry Numbers

CAS Registry Number

  • 2204245-48-5

FDA UNII

  • 8C7XEW3K7S

System Generated Number

  • 2204245485

Structure Descriptors

InChI

InChI=1S/C28H32F3N5O4S/c1-19-17-26(2,3)35(18-19)24-21(25(37)34-41(38,39)20-7-5-4-6-8-20)9-10-22(32-24)36-15-11-23(33-36)40-16-14-27(12-13-27)28(29,30)31/h4-11,15,19H,12-14,16-18H2,1-3H3,(H,34,37)/t19-/m0/s1

InChIKey

IGEOJNMYRZUKIK-IBGZPJMESA-N

Smiles

C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c3ccccc3)n4ccc(OCCC5(CC5)C(F)(F)F)n4)C(C)(C)C1