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Substance Name: Donepezil [INN:BAN]
RN: 120014-06-4
UNII: 8SSC91326P
InChIKey: ADEBPBSSDYVVLD-UHFFFAOYSA-N

Note

  • An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.

Molecular Formula

  • C24-H29-N-O3

Molecular Weight

  • 379.4971
 

Classification Codes

  • Central Nervous System Agents
  • Cholinergic Agents
  • Cholinesterase Inhibitors
  • Enzyme Inhibitors
  • Neurotransmitter Agents
  • Nootropic Agents

Names and Synonyms

Name of Substance

  • Donepezil
  • Donepezil [INN:BAN]

MeSH Heading

  • Donepezil

Synonyms

  • Donepezil
  • HSDB 7743
  • UNII-8SSC91326P

Systematic Name

  • 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-

Registry Numbers

CAS Registry Number

  • 120014-06-4

FDA UNII

  • 8SSC91326P

Related Registry Number

  • 120011-70-3

System Generated Number

  • 0120014064

Structure Descriptors

InChI

InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3

InChIKey

ADEBPBSSDYVVLD-UHFFFAOYSA-N

Smiles

COc1cc2CC(CC3CCN(Cc4ccccc4)CC3)C(=O)c2cc1OC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
women TDLo oral 1mg/kg (1mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: NAUSEA OR VOMITING

CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE
Annals of Pharmacotherpy. Vol. 33, Pg. 812, 1999.